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Unbound Medicine.
(Hormone replacement therapy)
38,225 results
  • Ulnar-Mammary syndrome with TBX3 gene mutation in a Chinese family: A case report and literature review. [Journal Article]
    Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Dec 28; 47(12):1769-1774.Peng N, Guo M, Jiang T
  • Ulnar-Mammary syndrome (UMS) is a rare monogenic disorder caused by mutations of the TBX3 gene. This paper reported a family of UMS. The proband, a 15-year old man, was presented with mammary gland dysplasia, ulnar limb defect, short stature, and delayed growth. Whole exome sequencing revealed a 1294_1301dup mutation in exon 6 of the TBX3 gene. Sanger sequencing was used to verify other members o…
  • Cardio-Metabolic Health and HRT in Menopause: Novel Insights in Mitochondrial Biogenesis and RAAS. [Journal Article]
    Curr Cardiol Rev. 2023 Feb 06 [Online ahead of print]Renke G, Kemen E, … Pereira MB
  • Recent evidence shows the cardiometabolic effects of estrogen administration in postmenopausal women. Women have a cardiometabolic advantage during their reproductive years, which is lost at menopause due to declining estradiol (E2). E2, also known as 17-beta-estradiol, has diverse effects in its target tissues, including the cardiovascular (CV) system, through genomic and non-genomic signaling. …
  • Diagnosis and Management of Idiopathic Hypothalamic Dysfunction: A Case Series and Systematic Review. [Systematic Review]
    Neuroendocrinology. 2023 Feb 06 [Online ahead of print]Xu Z, Wang Y, … Zhu H
  • Introduction Idiopathic hypothalamic dysfunction (IHD) is a rare syndrome with heterogeneous clinical symptoms. This study aimed to systematically review the clinical features and potential treatment of IHD based on our case series and literature. Methods We analysed six recently diagnosed cases of IHD in Peking Union Medical College Hospital and conducted a systematic review of IHD case studies …
  • Triphasic response after endoscopic craniopharyngioma resection and its dependency on infundibular preservation or sacrifice. [Journal Article]
    J Neurosurg. 2023 Feb 03 [Online ahead of print]Lopez DC, Almeida JP, … Recinos PF
  • CONCLUSIONS: Following endonasal craniopharyngioma resection, the triphasic response occurs in nearly half of infundibular transection cases. DI begins earlier with infundibular transection. On the basis of the study findings in which no patients met the criteria for SIADH or were endocrinologically unstable after postoperative day 6, it is reasonable to suggest that otherwise stable patients can be discharged at or before postoperative day 6 when ADH fluctuations have normalized and endocrinopathy is appropriately managed with oral desmopressin. Infundibular transection status may impact postoperative hormonal replacement strategies, but additional studies should evaluate their efficacies.
  • [Brain Metastasis Arising from Gastric Cancer during Long-Term Treatment Using Nivolumab]. [Case Reports]
    Gan To Kagaku Ryoho. 2022 Dec; 49(13):1544-1546.Namikawa T, Marui A, … Hanazaki K
  • Metastasis to the central nervous system from gastric cancer is exceedingly uncommon. We report a gastric cancer patient with cerebral metastasis during the period when durable response was obtained by systemic drug treatment using nivolumab. A 78-year-old male was referred to our hospital for further examination following diagnosis of gastric cancer by a local medical doctor. Esophagogastroduode…
  • The Women's Health Initiative randomized trials of menopausal hormone therapy and breast cancer: findings in context. [Journal Article]
    Menopause. 2023 Jan 24 [Online ahead of print]Chlebowski RT, Aragaki AK
  • CONCLUSIONS: Thirty commentaries challenging WHI findings were identified. All were reviewed, and issues needing response were identified. Findings from the meta-analysis from the Collaborative Group on Hormonal Factors in Breast Cancer and the Million Women Study were summarized and compared with finding in the two WHI randomized trials evaluating estrogen therapy and estrogen plus progestin. Based on the randomized clinical trials, estrogen therapy, for women with prior hysterectomy, decreases breast cancer incidence and mortality. In contrast, estrogen plus progestin increases breast cancer incidence, which persists through two decades. Women considering estrogen plus progestin use for vasomotor symptoms should understand the breast cancer risk.
  • The Clinical and Skeletal Effects of Long-Term Therapy of Hypoparathyroidism with rhPTH(1-84). [Journal Article]
    J Bone Miner Res. 2023 Feb 01 [Online ahead of print]Agarwal S, McMahon DJ, … Rubin MR
  • Hypoparathyroidism is a disorder characterized by hypocalcemia, low or absent parathyroid hormone (PTH) levels, reduced bone remodeling and high areal bone mineral density (aBMD). PTH is a therapeutic option, yet data on the prolonged clinical and skeletal effects of PTH treatment are limited. We tracked annual daily doses of calcium and active vitamin D supplements, calciotropic biochemistries, …
  • Does Drinking Coffee Reduce the Incidence of Parkinson's Disease? [Review]
    Cureus. 2023 Jan; 15(1):e34296.Ko TK
  • Parkinson's disease (PD) is an increasing threat to first-world nations as their population ages, with around one in 100 suffering from it by age 60. Incurable, with treatments that do little to delay disease progression, PD induces severe disability and even death in those afflicted. The search for preventative measures has revealed the widely used psychoactive stimulant caffeine, which competit…
  • Growth in girls with Turner syndrome. [Review]
    Front Endocrinol (Lausanne). 2022; 13:1068128.Isojima T, Yokoya S
  • Turner syndrome (TS) is a chromosomal disorder affecting females characterized by short stature and gonadal dysgenesis. Untreated girls with TS reportedly are approximately 20-cm shorter than normal girls within their respective populations. The growth patterns of girls with TS also differ from those of the general population. They are born a little smaller than the normal population possibly due…
  • Coronary artery disease in a patient with Addison's disease: a case report and literature review. [Case Reports]
    BMC Cardiovasc Disord. 2023 01 29; 23(1):54.Zhao R, Luo S, … Xiong F
  • CONCLUSIONS: The combination of Addison's disease and coronary artery disease in one patient is rare. Addison's disease can induce inflammation and disorders of water and electrolyte metabolism, which may further accelerate the course of coronary artery disease. Meanwhile, the hypotension in Addison's disease may affect the coronary blood flow, which may result in an increased susceptibility to unstable angina in the presence of coronary stenosis. So, we should analyze comprehensively if the coronary artery disease progress rapidly.
  • Sex Differences in Dementia. [Journal Article]
    Curr Top Behav Neurosci. 2023 Jan 26 [Online ahead of print]Hogervorst E, Temple S, O'Donnell E
  • BackgroundWomen in many cohorts have a higher risk for Alzheimer's disease (AD), the most common form of dementia. Sex is a biological construct whereby differences in disease manifestation and prevalence are rooted in genetic differences between XX and XY combinations of chromosomes. This chapter focuses specifically on sex-driven differences in dementia, as opposed to differences driven by gend…
  • [Endocrine disorders in patients with transfusion-dependent hereditary anemias]. [Journal Article]
    Probl Endokrinol (Mosk). 2022 Jul 27; 68(6):121-130.Vitebskaya AV, Bugakova ES, … Tikhonovich YV
  • Often transfusions red blood cells in patients with hereditary anemias lead to iron overload, that can cause endocrine complications, such as growth retardation, hypothyroidism, hypogonadism, and disorders of carbohydrate metabolism.Clinical case 1. A boy with transfusion-dependent (TD) Diamond-Blackfan anemia at 16.3 years presented with impaired fasting glucose, growth hormone (GH) deficiency, …
  • Stroke in Women and Unique Risk Factors. [Journal Article]
    Stroke. 2023 Feb; 54(2):587-590.Bushnell CD, Kapral MK
  • There has been a plethora of studies focused on female-specific risk factors and sex differences in stroke published in the past year. This article summarizes several of those novel studies which provide new knowledge about the field of stroke in women. The Nurses' Health Study II provides new data on the association between laparoscopically proven endometriosis and future stroke, accounting for …
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