- Common anticholinergic solanaceaous plants of temperate Europe - A review of intoxications from the literature (1966-2018). [Review]Toxicon. 2020 Apr 15; 177:52-88.T
- Datura stramonium, Atropa belladonna, Hyoscyamus niger, and Scopolia carniolica are all temperate plants from the family Solanaceae, which as a result of their anticholinergic tropane alkaloids, hyoscyamine/atropine and scopolamine, have caused many cases of poisoning around the world. Despite the danger these nightshade plants represent, the literature often presents incomplete cases lacking in …
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- [On the history of barbiturates]. [Historical Article]Dan Medicinhist Arbog. 2015; 43:133-51.DM
- Throughout the history of humanity, numerous therapeutic agents have been employed for their sedative and hypnotic properties such as opium, henbane (Hyoscyamus niger) and deadly nightshade (Atropa belladonna), but also alcohol and wine. In the 19th century potassium bromide was introduced as a sedative - and antiepileptic drug and chloral hydrate as sedative-hypnotics. A new era was reached by t…
- Black henbane and its toxicity - a descriptive review. [Review]
- Black henbane (BH) or Hyoscyamus niger, has been used as a medicine since last centuries and has been described in all traditional medicines. It applies as a herbal medicine, but may induce intoxication accidentally or intentionally. All part of BH including leaves, seeds and roots contain some alkaloids such as Hyoscyamine, Atropine, Tropane and Scopolamine. BH has pharmacological effects like b…
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- [Watch out for the sneaky relatives of the potato]. [Historical Article]Lakartidningen. 2014 Apr 29-May 13; 111(18-19):813-5.L
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- Wildflower (Hyoscyamus reticulatus) causes QT prolongation. [Journal Article]Bratisl Lek Listy. 2013; 114(6):333-6.BL
- CONCLUSIONS: Based on economical, social and cultural reasons, it is a very common habit in our country, especially in our region in spring and summer months, to consume some plants growing spontaneously in rural areas as food. Intoxication with Hyoscyamus reticulatus is a plant poisoning that is poorly described in literature. Its classical symptoms are predominantly anticholinergic. Although it is commonly self-limited and can be corrected with close observation and supportive treatments, it should be kept in mind that the prolongation of QT interval can accompany the symptoms of poisoning with this plant (Tab. 1, Fig. 3, Ref. 19).
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- [A massive poisoning by Hyoscyamus muticus, complicated by axonal sensorimotor polyneuropathy]. [Case Reports]Presse Med. 2013 Mar; 42(3):354-5.PM
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- Antiparkinsonian effects of aqueous methanolic extract of Hyoscyamus niger seeds result from its monoamine oxidase inhibitory and hydroxyl radical scavenging potency. [Journal Article]
- Hyoscyamus species is one of the four plants used in Ayurveda for the treatment of Parkinson's disease (PD). Since Hyoscyamus niger was found to contain negligible levels of L-DOPA, we evaluated neuroprotective potential, if any, of characterized petroleum ether and aqueous methanol extracts of its seeds in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. Air dried authent…
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- Clinical outcomes in children with hyoscyamus niger intoxication not receiving physostigmine therapy. [Journal Article]
- CONCLUSIONS: Our findings suggest that hyoscyamus niger intoxication in children is self-terminating and responds to supportive therapy and that routine use of physostigmine is unnecessary in every case with hyoscyamus niger intoxication.
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- Solanaceae III: henbane, hags and Hawley Harvey Crippen. [Historical Article]
- Hyoscyamus, the henbane, is one of the drugs of the ancients. Initially used both as a poison and narcotic, it was widely adopted by witches, wizards and soothsayers as a component of their hallucinatory and flying ointments. It was also used by notorious poisoners such as Madame Voisin in France. Eventually, in the nineteenth century its active principle was isolated by Ladenburg and called l-hy…
- [Intoxication with henbane]. [Case Reports]
- Henbane, Hyoscyamus niger, is a hallucinogenic plant, widely spread and easy accessible, which contains anticholinergic substances. Ingestion, intentional or accidental, can provoke serious worsening of psychophysical state and can cause even death. Intoxication resembles the one with atropine. Symptoms like mydriasis, tachycardia, arrhythmia, agitation, convulsion and coma can appear. Diagnosis …
- [Mystery of mydriatic pupils]. [Case Reports]
- The authors describe the case of a 27-year-old man who was examined on account of vertigo and blurred vision. In the objective case-history there was mild confusion, in the physical examination broad symmetrical mydriasis dominated. Later other similar patients were found. Atropine intoxication was proved. The source of the alkaloid was poppy seed contaminated with seeds of henbane (Hyoscyamus ni…
- Analysis of 156 cases of plant intoxication received in the Toxicologic Information Center at Catholic University of Chile. [Journal Article]Vet Hum Toxicol. 2002 Feb; 44(1):31-2.VH
- We present a retrospective analysis of plant and mushroom ingestions reported to the Toxicologic Information Center at the Catholic University of Chile. All the phone calls of plant and mushroom intoxications received from January 1998 through June 2000, were classified according to agent, clinical presentation, affected age group, origin of the phone call, and time from exposure to the toxic age…
- Hyoscyamus falezlez C: a poisonous plant of north Africa. [Review]Vet Hum Toxicol. 1996 Oct; 38(5):378-9.VH
- [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. [Journal Article]
- CONCLUSIONS: Potential and real intoxications with plant materials occurred in 7.2% of all cases registered at the STIC. However, among all plant cases only 0.6% were severe intoxications requiring hospitalization. Although severe plant intoxications are rare events, a small number of specific plants appear to be mainly responsible for continued serious plant poisoning in Switzerland. The present study has identified the plants with the highest toxicological risks and provides a data base for more rational prevention, diagnosis and treatment of plant poisoning cases in the future.
- [Plant poisoning cases in Turkey]. [Review]
- In Turkey, the majority of the population live in rural areas where they use wild plants as food and medicine. The confusion of an edible plant with a poisonous one give rise to serious poisoning which may even result in death. The incidence of plant poisoning in Turkey is about 6% and especially high among children between ages of 2 and 11 living in rural areas. The number of species that cause …
- [Psychopathologic manifestations of oral administration of endemic nightshade plants]. [Case Reports]
- Psychopathological findings in two cases of oral poisoning with toxins of "Datura stramonium" (thorn apple) and "Hyoscyamus niger" (insane roof) are reported. Toxicological aspects of voluntary ingestion are discussed as well as the forensic importance of criminal poisoning.
- [Henbane (Hyoscyamus reticulatus) poisoning in children in the Negev]. [Journal Article]
- During 1984-1989, 19 Bedouin children, 4-8 years old, were hospitalized because of henbane plant (Hyoscyamus reticulatus) poisoning. There were 14 cases in the autumn, 3 in the spring and 2 in the summer. The most prominent signs were altered state of consciousness (including deep coma in 3) and flushed dry, warm skin in all. Pupils were dilated in 18 of the 19 and restlessness and hallucinations…
- Mystery root ingestion. [Case Reports]
- Patients frequently come to the emergency department or contact a poison center following exposure to plants. These cases are often challenging owing to difficulty in correct identification of the involved plant. A case of two patients who demonstrated anticholinergic syndromes after ingesting an unknown, wild plant is described. Chemical analysis of two suspect plants collected in the same locat…
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- Henbane chewing. [Case Reports]Med J Aust. 1976 Jul 10; 2(2):55,58.MJ
- A case is presented of deliberate chewing of the flowers of henbane (Hyoscyamus niger) in the hope of producing euphoria, and an account is given of the poisoning so produced. The case indicates a more widespread use of this plant among the drug-taking community of Australia, and discussion of the case includes a description of the plant and an outline of treatment for the acute stage of the pois…
- Comparative study of the effect of atropine, P2AM, and Buscopan. Total belladonna and hyoscyamus alkaloids on parathion poisoning. [Journal Article]Pharmacology. 1976; 14(4):301-6.P
- Among the available antidotes used against parathion poisoning, atropine and Buscopan are tolerated in relatively high doses by rats. Hyoscine (in very small doses), T. Bel. Alk. and T. Hyosc. Alk. (better results in small doses, also for dogs), P2AM (of superior antimuscarine action) are redommended with each of the preceding drugs than either alone or in combination with Buscopan.
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- Henbane (Hyoscyamus niger) poisonings in the vicinity of Erzurum. [Journal Article]Turk J Pediatr. 1970 Jan-Apr; 12(1):48-56.TJ
- [POISONING WITH HYOSCYAMUS NIGER IN CHILDREN]. [Journal Article]Pediatr Akus Ginekol. 1964; 33:29-30.PA
- [ON POISONING OF CHILDREN BY HENBANE AND STRAMONIUM]. [Journal Article]Pediatriia. 1963 Jun; 42:72-4.P
- [A case of henbane poisoning]. [Journal Article]Azerbaidzhanskii Meditsinskii Zhurnal. 1961 May; 5:74-5.AM
- [On the problem of henbane (Hyoscyamus niger L.) poisoning in children]. [Journal Article]Vopr Okhr Materin Det. 1961 Mar; 6:93-4.VO
- [Case of criminal poisoning by ingestion of henbane seed; renewed outbreaks of these poisonings among the Moslem population]. [Journal Article]Alger Medicale. 1957 Jan; 61(1):17-26.AM