- Diabetic dyslipidaemia is associated with alterations in eNOS, caveolin-1 and endothelial dysfunction in streptozotocin treated rats. [Journal Article]
- DMDiabetes Metab Res Rev 2018 Feb 22
- CONCLUSIONS: The elevated serum Ox-LDL in hyperglycaemic STZ-diabetic rats may contribute to diabetic endothelial dysfunction, possibly through downregulation of endothelial CAV-1 and eNOS.
- [Type 2 Diabetes Diabetes in Older Adults: Example for Patient-Centered Drug Therapy]. [Journal Article]
- DMDtsch Med Wochenschr 2018; 143(4):253-261
- Diabetes in older adults has a high prevalence and is frequently associated with comorbidities of the cardiovascular system, dysfunction of cognition as well as depression and impaired mobility or in...
Diabetes in older adults has a high prevalence and is frequently associated with comorbidities of the cardiovascular system, dysfunction of cognition as well as depression and impaired mobility or increased frailty. Furthermore, impaired renal function, heart failure, risk for hypoglycemia and polypharmacy has to be considered in the decision about the diabetes treatment strategy. The goal of blood glucose management is driven by patient relevant issues and patient self-esteem, quality of life defined by the patient, preservation of physical and social mobility rather than potential long-term effects on reduction of cardio- and microvascular events in the future, which is limited by patient-inherent reduced life expectancy of the aged individual. Therefore, long-term diabetes medication should avoid hypoglycemia and prevent acute hyperglycemia or short-term complications on morbidity and clinical course of geriatric syndromes associated with regular blood glucose levels above 200 mg/dl (11.1 mmol/l). The therapy should be safe, easy to handle for the patient and possibly affect co-morbidities positively. However, there are limited data available about efficacy, safety and pharmacokinetics of drugs in patients over 75 years of age or older. Since more than 5 % of the population in Germany is older than 80 years means that more than 1 million of these individuals suffer from diabetes. It is time to ask for data in these elderly subpopulations by policy makers in health care.
- Is adjunctive photodynamic therapy more effective than scaling and root planing alone in the treatment of periodontal disease in hyperglycemic patients? A systematic review. [Review]
- PPPhotodiagnosis Photodyn Ther 2018 Feb 19
- CONCLUSIONS: It remains debatable whether adjunctive PDT as compared to SRP is effective in the treatment of periodontal inflammation and reduction of HbA1c levels in hyperglycemic patients.
- The Effect of Aronia Berry on Type 1 Diabetes In Vivo and In Vitro. [Journal Article]
- JMJ Med Food 2018 Feb 22
- The number of diabetic patients worldwide is increasing, and complications such as stroke and cardiovascular disease are becoming a serious cause of death. Diabetes mellitus is classified into two ty...
The number of diabetic patients worldwide is increasing, and complications such as stroke and cardiovascular disease are becoming a serious cause of death. Diabetes mellitus is classified into two types according to the etiopathogenic mechanism and insulin dependence. Type 1 diabetes (T1D), an insulin-dependent diabetes mellitus, is caused by damage and destruction of pancreatic β cells that produce insulin. It is a disease that is characterized by hyperglycemia and hypoinsulinemia. Aronia berry has been used as a medicinal food in Europe. Aronia contains a variety of ingredients such as polyphenols, anthocyanins, flavonoids, and tannins. Especially, anthocyanin content in aronia berry is known to be much higher than in other plants and berries. It is known for exerting antioxidant, anti-inflammation, and anti-aging effects. Therefore, this study was conducted to investigate the effects of aronia berry extract intake in multiple low-dose streptozotocin (STZ)-induced T1D and to confirm the functional properties of aronia berry. ICR mice (6-week male) were divided into four groups: control (normal control group), STZ (100 mg/kg of STZ-induced T1D group), AR 10 (STZ with oral administration of aronia 10 mg/kg), and AR 100 (STZ with oral administration of aronia 100 mg/kg). Afterward, STZ was injected in a single dose to induce T1D, and the extract was orally administered daily. Dietary intake and body weight were measured twice a week. We confirmed that aronia berry has the effect of decreasing the increase of blood glucose level and also has the protection effect of pancreas β cell (RINm5F cell). This study confirms the anti-diabetic activity of aronia berry, and it can be expected to increase the utilization according to the results.
- Intermittent food restriction in female rats induces SREBP high expression in hypothalamus and immediately postfasting hyperphagia. [Journal Article]
- NNutrition 2017 Dec 06; 48:122-126
- CONCLUSIONS: IFR affected the expression of SREBP-1c in R5 and SREBP-2 in the hypothalamus and caused overeating immediately after fasting in both groups. We suggest that hypothalamic and peripheral alterations, coupled with compulsive eating behavior in the ad libitum period, indicate risks for diabetes mellitus and recovery of body mass after interruption of IFR.
- NHS Diabetes Prevention Programme in England: formative evaluation of the programme in early phase implementation. [Journal Article]
- BOBMJ Open 2018 Feb 21; 8(2):e019467
- CONCLUSIONS: The NHS DPP provides an evidence-based behavioural intervention for prevention of T2D in adults at high risk, with capacity to deliver nationally. Framework specification allows for balance between consistency and contextual variation in intervention delivery, with session details devolved to providers. Limitations in fidelity assurance, data collection procedures and recruitment issues could adversely impact on intervention effectiveness and restrict evaluation.
- Blood flow characteristics of diabetic patients with complications detected by optical measurement. [Journal Article]
- BEBiomed Eng Online 2018 Feb 21; 17(1):25
- CONCLUSIONS: Our results suggest that DM patients, and DM patients with complications, have unique peripheral blood flow characteristics.
- Pituitary adenylate cyclase-activating polypeptide ameliorates vascular dysfunction induced by hyperglycaemia. [Journal Article]
- DVDiab Vasc Dis Res 2018 Feb 01; :1479164118757922
- CONCLUSIONS: These results suggest a strong protective role of PACAP in the vascular complications of diabetes.
- Effect of flavonoid rich fraction of Tephrosiapurpurea (Linn.) Pers. on complications associated with streptozotocin-induced type I diabetes mellitus. [Journal Article]
- IJIndian J Exp Biol 2016; 54(7):457-466
- Globally, diabetes is a serious health issue affecting one in 11 adults and consumes 12% of global health expenditure. Prevalence of dyslipidemia in diabetes is not uncommon since decades. Further, p...
Globally, diabetes is a serious health issue affecting one in 11 adults and consumes 12% of global health expenditure. Prevalence of dyslipidemia in diabetes is not uncommon since decades. Further, patients with type II diabetes have 2-4 folds more risk for cardiovascular disease (CVD). Plants with antioxidant potential are known to have beneficial effects in diabetes and its complications: Natural compounds, flavonoids particularly, ameliorate hyperglycemia as well as CVD. Here, we evaluated common wasteland weed Tephrosia purpurea, used traditionally as folk medicine to treat many disorders including diabetes. We studied the effect of 8-wk treatment of flavonoid-rich fraction of T. purpurea (FFTp) (40 mg/kg/day/p.o.) on various biochemical, cardiovascular and lenticular parameters on streptozotocin (STZ) (45 mg/kg, i.v.) induced type I diabetic rats. STZ administration produced significant hyperglycemia, dyslipidemia, and altered cardiac biomarkers like lactate dehydrogenase, creatinine kinase and reduced antioxidants in lenticular tissues of rats. Treatment with FFTp significantly prevented STZ-induced hyperglycemia, dyslipidemia as well as cardiovascular markers. We observed decreased rate of pressure development (+dp/dt) and decay (-dp/dt) in STZ diabetic hearts which was prevented by FFTp. Further, the soluble protein levels and the antioxidants were also elevated in the diabetic rats by the treatment. In conclusion, our data suggest that FFTp produces beneficial effects on diabetes induced cardiovascular complications and cataract. Such beneficial actions may be attributed to the antioxidant property of flavonoids, quercetin or rutin, present in T. purpurea.
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- Colorimetric detection of 1,5-anhydroglucitol based on graphene quantum dots and enzyme-catalyzed reaction. [Journal Article]
- IJInt J Biol Macromol 2018 Feb 18
- Early diagnosis of diabetes yields significant clinical benefits. The serum level of 1,5‑anhydroglucitol (1,5‑AG) has been a new biochemical marker for postprandial hyperglycemia. In this study, a si...
Early diagnosis of diabetes yields significant clinical benefits. The serum level of 1,5‑anhydroglucitol (1,5‑AG) has been a new biochemical marker for postprandial hyperglycemia. In this study, a simple colorimetric method for 1,5‑AG detection has been designed based on highly efficient peroxidase mimetic activity of GQDs and enzyme-catalyzed reaction. By the catalytic action of pyranose oxidase (PROD), the 1,5‑AG was oxidized to 1,5‑anhydrofuctose and H2O2. The GQDs in the presence of H2O2exhibited highly efficient catalytic activity toward the oxidation of 3, 3', 5, 5'‑tetramethylbenzidine (TMB) to a blue colored product. The influence of relevant experimental variables was optimized. A linear relationship of optical signal with the concentration of 1,5‑AG in the range of 20.0-100.0 μg/mL with the regression correlation coefficient of 0.9985 was obtained which could be monitored by colorimetry detection. The limit of detection (LOD) for 1,5‑AG detection was approximately 0.144 μg/mL. All in all, the proposed 1,5‑AG detection system based on GQDs and PROD-catalyzed reaction showed better performances with simple operation, low-cost, higher selectivity.