- Characterization of sulfuretin as a depigmenting agent. [Journal Article]
- FCFundam Clin Pharmacol 2018 Sep 14
- Sulfuretin is a major flavonoid found in Rhus verniciflua and carries anti-oxidative and anti-inflammatory properties, but its potential use in the control of skin pigmentation is unknown. The purpos...
Sulfuretin is a major flavonoid found in Rhus verniciflua and carries anti-oxidative and anti-inflammatory properties, but its potential use in the control of skin pigmentation is unknown. The purpose of the present study was to elucidate sulfuretin as a new active compound inhibiting melanogenesis and the underlying mechanism. The effects of sulfuretin on melanin production, tyrosinase activity, cAMP level and MITF expression were examined in murine melanoma B16 cells challenged with forskolin or α-MSH. The inhibitory effect of sulfuretin on melanogenesis was further validated on neonatal human melanocytes. When tested in melanoma B16 cells treated with forskolin or α-MSH, sulfuretin inhibited the cellular melanogenesis. Sulfuretin also showed direct inhibitory effect on tyrosinase activity in vitro. In human primary melanocytes, the inhibitory effect of sulfuretin on melanin synthesis was also confirmed. Our current results support the depigmenting effect of sulfuretin and suggest a clinical strategy for using sulfuretin in the topical treatment of hyperpigmentation disorders. This article is protected by copyright. All rights reserved.
- Polymorphisms in P53 and VEGFA genes in different subtypes of periorbital hyperpigmentation in a Malaysian Chinese population. [Journal Article]
- AJAustralas J Dermatol 2018 Sep 14
- CONCLUSIONS: Mixed subtype was the most prevalent type of periorbital hyperpigmentation in the study population. Three polymorphisms in p53 and VEGFA genes were statistically linked with different clinical presentations of periorbital hyperpigmentation.
- Oblique Inguinal Incision in Bernese Periacetabular Osteotomy: Surgical Technique. [Journal Article]
- JAJ Am Acad Orthop Surg Glob Res Rev 2017; 1(9):e061
- CONCLUSIONS: Oblique inguinal incision for the anterior approach in Bernese periacetabular osteotomy is a technique that allows healing of surgical wounds without dehiscence or hypertrophic changes by respecting tension lines. It has a high rate of patient satisfaction, with no complications.
- Single fraction of accelerated partial breast irradiation in the elderly: early clinical outcome. [Journal Article]
- RORadiat Oncol 2018 Sep 12; 13(1):174
- CONCLUSIONS: We reported promising and encouraging clinical outcome of a post-operative single fraction of MIB ABPI in the elderly. This approach leads to consider a sfAPBI as an attractive alternative to intra-operative radiation therapy while all the patients will be good candidates for APBI in regards to the post-operative pathological report. More mature results (number of patients and follow-up) are needed.
- Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report. [Journal Article]
- JMJ Med Case Rep 2018 Sep 11; 12(1):254
- CONCLUSIONS: Keen observation on the part of physicians is mandatory during the administration of ivermectin for quick recognition and prevention of this adverse drug reaction.
- The effects of Antimicrobial Peptides and Hyaluronic Acid compound mask on wound healing after ablative fractional Carbon Dioxide laser resurfacing. [Journal Article]
- JCJ Cosmet Laser Ther 2018 Sep 10; :1-8
- CONCLUSIONS: Application of AMPs and HA compound mask is an effective method for enhancing wound healing after FxCR, by reducing transient adverse effects such as erythema, hyperpigmentation, and increased TEWL.
- The potential role of antioxidants in mitigating skin hyperpigmentation resulting from ultraviolet and visible light induced oxidative stress. [Review]
- PPPhotodermatol Photoimmunol Photomed 2018 Sep 10
- Oxidative stress is an integral element that influences a variety of biochemical reactions throughout the body and is known to play a notable role in melanogenesis. Exogenous triggers of oxidative st...
Oxidative stress is an integral element that influences a variety of biochemical reactions throughout the body and is known to play a notable role in melanogenesis. Exogenous triggers of oxidative stress, such as ultraviolet radiation (UVR) and visible light (VL), lead to pigment formation through somewhat different pathways, but both share a common endpoint - the potential to generate cosmetically undesirable hyperpigmentation. Though organic and inorganic sunscreens are available to protect against the UVR portion of the electromagnetic spectrum, coverage is lacking to protect against the VL spectrum. In this manuscript, we review the phases of tanning, pathways of melanogenesis triggered by UVR and VL, and the associated impact of oxidative stress. We also discuss the known intrinsic mechanisms and paracrine regulation of melanocytes that influence their response to UVR. Understanding these mechanisms and their role in UVR induced hyperpigmentation should potentially lead to identification of useful targets that can be coupled with antioxidant therapy to alleviate this effect. This article is protected by copyright. All rights reserved.
- The Nail Flag Sign: Case Report in a Man with Diverticulitis and Review of Dermatology Flag Sign of the Hair, Skin, and Nails. [Journal Article]
- CCureus 2018 Jul 05; 10(7):e2929
- A sign is a physical feature or microscopic change which can be observed when the patient or their tissue specimen is evaluated. An astute clinician or pathologist may be able to diagnose a patient's...
A sign is a physical feature or microscopic change which can be observed when the patient or their tissue specimen is evaluated. An astute clinician or pathologist may be able to diagnose a patient's condition by recognizing this unique morphologic feature or pathological change. In dermatology, the flag sign-alternating transverse bands of the skin or its adnexal structures that are analogous to the alternating colors of the stripes of a flag-has been associated with distinctive disorders of the hair, skin, or nails. The hair flag sign is characterized by alternating horizontal bands of hypopigmentation of the hair (in children with kwashiorkor type of protein-calorie malnutrition) or hyperpigmentation of the hair (in a male child who has intravenously received several cycles of high-dose methotrexate). In skin, the flag sign can be observed microscopically in actinic keratosis, and demonstrates by alternating parakeratosis and orthokeratosis of the stratum corneum-corresponding to the type of hyperkeratosis occurring above the interadnexal epidermis or the ostea of the acrosyringia and acrotrichia. The nail flag sign-noted in some individuals who have diabetes mellitus, diverticulitis, leprosy, or vitiligo-presents with alternating white and pink-red horizontal bands beginning at the proximal nail fold and extending distally to the free edge of the nail plate. A man with chronic diverticulitis and the nail flag sign is reported; he also has a history of congenital leukonychia, actinic keratoses, basal cell carcinoma and psoriasis. In addition, the features of hair, skin, and nail flag signs are reviewed. The detection of the dermatology flag sign can prompt a pathologist to consider the diagnosis of actinic keratosis. Alternating horizontal bands of hair color can indicate protein-calorie malnutrition or an effect of chemotherapy in a child. Certain autoimmune, inflammatory, or infectious conditions in individuals present with white and pink-red horizontal bands on their nails.
- A Long-term Safety Study of Latanoprost in Pediatric Patients with Glaucoma and Ocular Hypertension: A Prospective Cohort Study. [Journal Article]
- AJAm J Ophthalmol 2018 Sep 05
- CONCLUSIONS: Latanoprost had an acceptable safety profile with no evidence of inducing clinically meaningful or statistically significant changes in ocular development or ocular hyperpigmentation in pediatric patients with glaucoma and ocular hypertension HYPERLINK "http://[ClinicalTrials.gov" \o "http://[ClinicalTrials.gov"Error! Hyperlink reference not valid. identifiers: NCT01265719].
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- Protopanaxatriol inhibits melanin synthesis through inactivation of the pCREB-MITF-tyrosinase signalling pathway in melanocytes. [Journal Article]
- CEClin Exp Dermatol 2018 Sep 08
- Ginsenosides are major active components of ginseng, and have diverse pharmacological properties in traditional medicine. Recent reports have shown that ginsenosides modify skin physiology and mitiga...
Ginsenosides are major active components of ginseng, and have diverse pharmacological properties in traditional medicine. Recent reports have shown that ginsenosides modify skin physiology and mitigate skin disorders such as photoageing and hyperpigmentation. We evaluated the antimelanogenic efficacy of protopanaxatriol, a major category of ginsenosides, as a depigmenting agent. Protopanaxatriol significantly reduced intracellular and extracellular melanin content in a concentration-dependent manner in B16 melanoma cells treated with α-melanocyte-stimulating hormone. In normal human epidermal melanocytes, protopanaxatriol clearly decreased melanin synthesis and dendrite elongation. In addition, protopanaxatriol dramatically suppressed the expression of genes encoding the melanogenic proteins tyrosinase, tyrosinase-related protein-1 and -2, and microphthalmia-associated transcription factor through dephosphorylation of cAMP response element-binding protein. These results suggest that protopanaxatriol could be an effective candidate anti-melanogenic agent.