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47,911 results
  • Low frequency of positive antithyroid antibodies is observed in patients with thyroid dysfunction related to immune check point inhibitors. [Journal Article]
  • JEJ Endocrinol Invest 2019 May 15
  • Mazarico I, Capel I, … Rigla M
  • CONCLUSIONS: 8 of the 11 patients were treated with nivolumab and the other three patients received pembrolizumab. Six patients presented silent thyroiditis with a thyrotoxicosis phase; three patients developed directly primary/subclinical hypothyroidism and two patients showed primary hyperthyroidism. Thyroid autoantibodies (anti-Thyroglobulin and anti-Thyroid Peroxidase) were assessed in all the 11 patients, and only in two of them (18%) a positive titer was displayed. Anti-TSH receptor antibodies (TRAbs) were examined in five patients, three with painless thyroiditis at the time of thyrotoxicosis and two with primary hyperthyroidism, and they all had undetectable levels.In our sample of 11 Caucasian patients with thyroid dysfunction related with anti-PD1, we found low frequency of ATA positive titers, comparable to other recent reports in others ethnicities, which could suggest that silent thyroiditis due to pembrolizumab or nivolumab has a different pathogenesis from the classical autoimmune spontaneous thyroiditis. Further investigations are required to completely understand the immune mechanisms involved.
  • Angiopoietin-2: a biomarker in hyperthyroidism. [Journal Article]
  • TBTheor Biol Forum 2018 Jan 01; 111(1-2):57-66
  • Ndreu R, Lubrano V, … Balzan S
  • Serum angiopoietin-2 level is e le vated in several diseases suggesting its possible role as a mediator of angiogenesis and vascular network remodeling. Triiodothyronine and thyroxine have well docum…
  • Body composition, resting energy expenditure and metabolic changes in women diagnosed with differentiated thyroid carcinoma. [Journal Article]
  • TThyroid 2019 May 15
  • Izkhakov E, Vaisman N, … Keinan-Boker L
  • CONCLUSIONS: REE, REE/LBM, pulse, and systolic and diastolic blood pressure were significantly higher after thyroidectomy, radioiodine and TSH suppressive therapy in female DTC patients, while no changes were observed in body weight or body composition. A lower TT3/FT4 ratio longitudinally correlated with increases in REE, REE/LBM, abdominal fat distribution, systolic blood pressure and fasting blood glucose, as well as with decreased RQ. These findings highlight the importance of judicial balancing of the benefits and detriments of TSH suppression with subsequent decreased TT3/FT4 ratios for female DTC patients.
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