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10,768 results
  • CO2-related vasoconstriction superimposed on ischemic medullary brain autonomic nuclei may contribute to sudden death. [Editorial]
  • CPCardiovasc Pathol 2018 Oct 26; 38:42-45
  • Jaster JH, Zamecnik J, … Ottaviani G
  • CONCLUSIONS: Why did not the improved pulmonary ventilation and subsequently improved gas exchange provided during the CPAP and servoventilation clinical trials help to resolve any ischemic lesions that may have been present both in the heart and in the medulla, thereby tending to normalize interactions between the vagal neural structures and the heart? CO2 is a potent dilator of brain vasculature, thereby increasing blood flow to the brain. When ventilation is increased, even if only to improve it back toward normal from a depressed steady-state level, the alveolar partial pressure of carbon dioxide is decreased, likely resulting in a converse relative vasoconstriction in the brain, thereby reducing blood flow in the brain, especially in watershed areas like the solitary tract nucleus. In normal physiology, this is demonstrated impressively by the ability of hyperventilation to induce loss of consciousness.The findings of several clinical trials recently reported, taken together with neuropathology case studies reported elsewhere, suggest that additional research is warranted in regard to the mechanisms by which focal medullary autonomic brain ischemia may be related to sudden death in general medical illnesses - and how it may additionally be influenced by changes in arterial CO2 levels.
  • Electroclinical Features of Generalized Paroxysmal Fast Activity in Typical Absence Seizures. [Journal Article]
  • JCJ Clin Neurophysiol 2018 Nov 01
  • Bansal L, Vargas Collado L, … Abdelmoity A
  • CONCLUSIONS: Generalized paroxysmal fast activity is uncommon in children with typical absence seizures and has medium voltage, posterior predominance, and marked female preponderance. Generalized paroxysmal fast activity is seen during both pharmacoresponsive and drug-resistant epilepsy, and is not affected by antiseizure medications. It may serve as an independent marker of lifelong epilepsy.
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