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10,745 results
  • Therapeutic hypothermia to reduce intracranial pressure after traumatic brain injury: the Eurotherm3235 RCT. [Clinical Trial]
  • HTHealth Technol Assess 2018; 22(45):1-134
  • Andrews PJ, Sinclair HL, … Murray G
  • CONCLUSIONS: In participants following TBI and with an ICP of > 20 mmHg, titrated therapeutic hypothermia successfully reduced ICP but led to a higher mortality rate and worse functional outcome.Inability to blind treatment allocation as it was obvious which participants were randomised to the hypothermia group; there was biased recording of SAEs in the hypothermia group. We now believe that more adequately powered clinical trials of common therapies used to reduce ICP, such as hypertonic therapy, barbiturates and hyperventilation, are required to assess their potential benefits and risks to patients.
  • [Anamnestic headache in patients with cervical artery dissection: clinical characteristics and pathogenetic mechanisms]. [Journal Article]
  • ZNZh Nevrol Psikhiatr Im S S Korsakova 2018; 118(7):4-11
  • Kalashnikova LA, Dobrynina LA, … Timiraysova AA
  • CONCLUSIONS: HPH in patients with CeAD meets criteria of migraine in 15.4% (with aura - 3.1%, without aura - 12.3%), 29.1% patients have nonmigraine HPH. Central mechanisms, namely, the hypersensitivity of the cerebral cortex playing the main role in migraine pathogenesis, are not significant in HPH genesis. The main role appears to have peripheral mechanisms - dysplastic changes in the wall of extra- and intracranial arteries that predispose both to headache and dissection.
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