- Hypothermia detection in low birth weight neonates using a novel bracelet device. [Journal Article]
- JMJ Matern Fetal Neonatal Med 2018 Feb 20; :1-11
- CONCLUSIONS: The BEMPU Bracelet is an accurate screening tool to detect and alert for neonatal hypothermia, thereby facilitating prompt management, which could prevent complications.
- Facing coagulation disorders after acute trauma. [Journal Article]
- BB-ENT 2016; Suppl 26(1):67-85
- CONCLUSIONS: TIC appears quickly after trauma and should be anticipated and detected as soon as possible. TXA plays a central role in the management of such patients. Each institution should establish a local algorithm for the management of bleeding patients.
- Use of Cold Fluids in Postcardiac Arrest Therapeutic Hypothermia: A Safety Analysis. [Journal Article]
- THTher Hypothermia Temp Manag 2018 Feb 20
- Therapeutic hypothermia (TH) has been part of the standard care of postresuscitation patients for more than a decade. Multiple cooling methods are available, including the administration of cold intr...
Therapeutic hypothermia (TH) has been part of the standard care of postresuscitation patients for more than a decade. Multiple cooling methods are available, including the administration of cold intravenous (IV) fluids. Although this method is widely used, the safety of administration of large volumes of cold IV fluids has not been clearly demonstrated in the literature, and recent evidence points to potential deleterious effects associated with administration of large IV fluid volumes. We conducted a retrospective cohort study among patients who have been treated with TH after cardiac arrest between November 2011 and November 2013 at a tertiary care hospital in Sherbrooke, Quebec, Canada. The primary outcome was the effect of IV fluid quantity on the 28-day survival rate. We reviewed 29 cases, with a total 28-day surviving rate of 51.7%. After adjusting for confounding variables, 28-day surviving rate was not significantly associated with the amount of fluids administrated (odds ratio = 1.034; confidence interval 95% [0.741-1.464]; p = 0.85). The amount of fluids did not influence the variation of the pulmonary component of the sequential organ failure assessment score between days 1 and 3 (ρ = -0.2, p = 0.34). Despite a small sample of patients, cold IV fluids in TH appear safe in the postcardiac arrest population. These findings should be reproduced in a larger, prospective study.
- Cirp expression and therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE): a factor to consider when selecting depth and duration of cooling? [Journal Article]
- MPMinerva Pediatr 2018 Feb 19
- Thyroid Function of Asphyxiated Newborns who Received Hypothermia Therapy. [Journal Article]
- PIPediatr Int 2018 Feb 20
- CONCLUSIONS: These results suggest that asphyxiated newborns have transient low thyroid hormone levels at 24-96 hours after birth. Serum FT3 and FT4 levels between 72 and 96 hours after birth may predict brain injury of asphyxiated newborns. This article is protected by copyright. All rights reserved.
- Role of superoxide ion formation in hypothermia/rewarming induced contractile dysfunction in cardiomyocytes. [Journal Article]
- CCryobiology 2018 Feb 16
- Rewarming following accidental hypothermia is associated with circulatory collapse due primarily to impaired cardiac contractile (systolic) function. Previously, we found that reduced myofilament Ca2...
Rewarming following accidental hypothermia is associated with circulatory collapse due primarily to impaired cardiac contractile (systolic) function. Previously, we found that reduced myofilament Ca2+sensitivity underlies hypothermia/rewarming (H/R)-induced cardiac contractile dysfunction. This reduced Ca2+sensitivity is associated with troponin I (cTnI) phosphorylation. We hypothesize that H/R induces reactive oxygen species (ROS) formation in cardiomyocytes, which leads to cTnI phosphorylation and reduced myofilament Ca2+sensitivity. To test this hypothesis, we exposed isolated rat cardiomyocytes to a 2-h period of severe hypothermia (15 °C) followed by rewarming (35 °C) with and without antioxidant (TEMPOL) treatment. Simultaneous measurements of cytosolic Ca2+([Ca2+]cyto) and contractile (sarcomere shortening) responses indicated that H/R-induced contractile dysfunction and reduced Ca2+sensitivity was prevented in cardiomyocytes treated with TEMPOL. In addition, TEMPOL treatment blunted H/R-induced cTnI phosphorylation. These results support our overall hypothesis and suggest that H/R disrupts excitation-contraction coupling of the myocardium through a cascade of event triggered by excessive ROS formation during hypothermia. Antioxidant treatment may improve successful rescue of accidental hypothermia victims.
- Factors affecting extubation time following pediatric ambulatory surgery: an analysis using electronic anesthesia records from an academic university hospital. [Journal Article]
- JCJA Clin Rep 2017; 3(1):38
- CONCLUSIONS: This study of 148 pediatric patients demonstrated that anesthesia emergence may be associated with mBT and mETCO2following pediatric ambulatory surgery. These results show that perioperative vital signs are important in the prevention of delayed emergence for pediatric patients.
- Abdominal compartment syndrome during hip arthroscopy for an acetabular fracture: a case report. [Journal Article]
- JCJA Clin Rep 2017; 3(1):24
- CONCLUSIONS: Anesthesiologists should be aware of the possible occurrence of the abdominal compartment syndrome during hip arthroscopic surgery and ensure that it is detected early.
- Sustainability of anaesthesia components of an enhanced recovery program (ERP) in colorectal and orthopaedics surgery. [Journal Article]
- ACAnaesth Crit Care Pain Med 2018 Feb 15
- CONCLUSIONS: This study shows on a large scale a trend towards less application of all ERP items over time. Continuous audits should be encouraged to expect further improvements.
New Search Next
- Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury. [Journal Article]
- BBBrain Behav Immun 2018 Feb 14
- Acute hypothermia treatment (HT) is the only clinically established intervention following neonatal hypoxic-ischemic brain injury. However, almost half of all cooled infants still die or suffer from ...
Acute hypothermia treatment (HT) is the only clinically established intervention following neonatal hypoxic-ischemic brain injury. However, almost half of all cooled infants still die or suffer from long-lasting neurological impairments. Regenerative therapies, such as mesenchymal stem cells (MSC) appear promising as adjuvant therapy. In the present study, we hypothesized that HT combined with delayed MSC therapy results in augmented protection, improving long-term neurological outcome. Postnatal day 9 (P9) C57BL/6 mice were exposed to hypoxia-ischemia followed by 4 hours HT. Murine bone marrow-derived MSC (1x106cells / animal) were administered intranasally at P12. Cytokine and growth factor levels were assessed by ELISA and Luminex® multiplex assay 24 hours following MSC delivery. One week after HI, tissue injury and neuroinflammatory responses were determined by immunohistochemistry and western blot. Long-term motor-cognitive outcome was assessed 5 weeks post injury. MSC responses to the brains' environment were evaluated by gene expression analysis in MSC, co-cultured with brain homogenates isolated at P12. Both, MSC and HT improved motor deficits, while cognitive function could only be restored by MSC. Compared to each single therapy, combined treatment led to increased long-lasting motor-cognitive deficits and exacerbated brain injury, accompanied by enhanced endothelial activation and peripheral immune cell infiltration. MSC co-cultured with brain extracts of HT-treated animals revealed increased pro-inflammatory cytokine and decreased growth factor expression. In vivo protein analysis showed higher pro-inflammatory cytokine levels after combined treatment compared to single therapy. Furthermore, HI-induced increase in growth factors was normalized to control levels by HT and MSC single therapy, while the combination induced a further decline below control levels. Our results suggest that alteration of the brains' microenvironment by acute HT modulates MSC function resulting in a pro-inflammatory environment combined with alteration of the homeostatic growth factor milieu in the neonatal hypoxic-ischemic brain. This study delineates potential unexpected side effects of cell-based therapies as add-on therapy for acute hypothermia treatment.