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44,362 results
  • Occurrences and Outcomes of Immune Checkpoint Inhibitors-Induced Vitiligo in Cancer Patients: A Retrospective Cohort Study. [Journal Article]
    Drug Saf 2019Babai S, Voisin AL, … Le-Louet H
  • CONCLUSIONS: This study provided an overall picture of ICI-induced vitiligo in daily medical practice on a large number of pharmacovigilance observations of case patients. Among the observations of ICI-induced vitiligo, the diagnosed cancer was melanoma for almost all patients. Most patients in the study experienced other associated adverse drug reactions (ADRs), such as colitis, pruritus, hypothyroidism, hyperthyroidism, thyroiditis, pancreatitis, and gastritis. Furthermore, our data suggest that the resolution of pembrolizumab- or nivolumab-induced vitiligo could be a marker of disease progression. Future studies evaluating vitiligo outcomes are warranted.
  • Medication-induced obstructive uropathy and hyperprolactinemia in a pediatric patient. [Case Reports]
    Clin Case Rep 2019; 7(10):1928-1931Nkansah-Amankra K, Sudhanthar S
  • Hyperprolactinemia can result from a pituitary tumor or decreased dopamine levels due to compression of the pituitary stalk. Hypothyroidism, renal failure, and drug interaction need to be ruled out as a part of diagnostic evaluation. The prolactin level often indicates the etiology, but drug interaction needs to be ruled out mainly in a patient who is on multiple medications.
  • A case of extreme hyponatremia without neurologic symptoms. [Case Reports]
    Clin Case Rep 2019; 7(10):1874-1879Zhou N, Yang C
  • Our case report highlights that profound hyponatremia with sodium level 101 mmol/L could have no CNS symptoms, and drugs and endocrine disorders are relatively common causes and should be considered in the differential diagnosis of hyponatremia. Standard dose trimethoprim-sulfamethoxazole-induced hyponatremia is rare but still worth close attention in clinical practice.
  • Assessment of the Adequacy of Thyroid Hormone Replacement Therapy in Hypothyroidism. [Journal Article]
    Front Endocrinol (Lausanne) 2019; 10:631Brokhin M, Danzi S, Klein I
  • Background: Recent studies identify a significant number of treated hypothyroid patients who express dissatisfaction with their therapy. At present there are sufficient measures of thyroid function to enable the clinician to establish a diagnosis of thyroid disease with a high degree of sensitivity and specificity. The purpose of this study was to quantitate the use of a new and novel assessment…
  • Transient neonatal hypothyroidism secondary to postnatal maternal exposure to contrast medium. [Journal Article]
    BMJ Case Rep 2019; 12(10)Themelin C, Pierron C, … de Beaufort C
  • We report a preterm breastfed infant who developed a transient hypothyroidism after his lactating mother had a CT scan with iodinated contrast medium, despite the advised 24 hours' pause in breast feeding. The aetiological assessment did not show any other cause for this hypothyroidism. Transient neonatal hypothyroidism after the use of topical iodine is well known, but it has not been described …
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