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877,386 results
  • Daratumumab treatment for therapy-refractory anti-CASPR2 encephalitis. [Journal Article]
    J Neurol 2019Scheibe F, Ostendorf L, … Meisel A
  • The anti-CD38 antibody daratumumab is approved for treatment of refractory multiple myeloma and acts by depletion of plasma cells and modification of various T-cell functions. Its safety, immunological effects and therapeutic potential was evaluated in a 60-year old patient with life-threatening and treatment-refractory anti-CASPR2 encephalitis requiring medical care and artificial ventilation in…
  • Structural Insights into the Interleukin-17 Family Cytokines and Their Receptors. [Journal Article]
    Adv Exp Med Biol 2019; 1172:97-117Liu S
  • The IL-17 family in humans consists of six distinct cytokines (IL-17A-F) that can interact with five IL-17 receptors (IL-17RA-E). The interaction between these cytokines and their receptors are critical in mediating host defenses while also making major contributions to inflammatory and autoimmune responses as demonstrated through both in vitro and in vivo experiments as well as human clinical tr…
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