- Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats. [Journal Article]
- DRDrug Res (Stuttg) 2019 Jul 17
- CONCLUSIONS: The results show NG has a protective effect on renal tissue against AKI caused by I-R. These protective effects mediated through antioxidant activity and decrease of lipid peroxidation.
- Triglyceride Glucose Index Predicting Cardiovascular Mortality in Chinese Initiating Peritoneal Dialysis: A Cohort Study. [Journal Article]
- KBKidney Blood Press Res 2019 Jul 17; :1-10
- CONCLUSIONS: TyG index might be a prognostic factor in predicting cardiovascular mortality among patients initiating PD.
- Molecular indicators of denervation in ageing human skeletal muscle. [Journal Article]
- MNMuscle Nerve 2019 Jul 17
- CONCLUSIONS: Muscle from healthy older individuals expresses developmental myosins to varying degrees, but more than previous reports for young individuals. Along with the AchR correlations, we propose that these findings support the presence of neuromuscular junction destabilization, denervation and re-innervation in aging human skeletal muscle. This article is protected by copyright. All rights reserved.
- Elevated Insulin and Insulin Resistance are Associated with Altered Myelin in Cognitively Unimpaired Middle-Aged Adults. [Journal Article]
- OObesity (Silver Spring) 2019 Jul 17
- CONCLUSIONS: The results suggest that insulin and IR influence white matter myelination in a cognitively unimpaired population. Additional studies are needed to determine the extent to which this may contribute to cognitive decline or vulnerability to neurodegenerative disease.
- Comparison of malachite green adsorption by two yeast strains using Raman microspectroscopy. [Journal Article]
- FMFEMS Microbiol Lett 2019 Jul 17
- Malachite green (MG), as a triarylmethane compound, poses a health hazard and cause considerable environmental concern. In this work, batch biosorption experiments were conducted under different oper…
Malachite green (MG), as a triarylmethane compound, poses a health hazard and cause considerable environmental concern. In this work, batch biosorption experiments were conducted under different operational conditions such as pH, contact time and adsorption dose to assess the optimal parameters of MG dye removal by yeast biomass from aqueous solution. Then, the conventional biochemical assay was used to evaluate MG removal efficiency (75.18% and 95.85%) by S. cerevisiae and C. utilis. In addition, Fourier-transform infrared (FT-IR) spectroscopy in combination with Raman microspectroscopy was employed to scrutinize the differences of dye removal between two types of yeast strains. This study demonstrates that Raman microspectroscopy may serve as a useful and powerful tool to quantitatively measure the content of MG dye on yeast cell surfaces in situ, and it even offer an alternative new technique to seek potentially proper adsorbents for the removal of toxic dyes from industrial effluents.
- A coordinatively unsaturated iridium complex with an unsymmetrical redox-active ligand: (spectro)electrochemical and reactivity studies. [Journal Article]
- DTDalton Trans 2019 Jul 17
- Redox-active ligands, owing to their electron reservoir capability, are well suited for the generation of coordinatively unsaturated metal complexes. We present here iridium complexes with an unsymme…
Redox-active ligands, owing to their electron reservoir capability, are well suited for the generation of coordinatively unsaturated metal complexes. We present here iridium complexes with an unsymmetrically substituted o-phenylenediamine ligand. A coordinatively unsaturated, formally iridium(iii) complex with the fully reduced o-phenylenediamide (or o-diamidobenzene) ligand was isolated and structurally characterized. This coordinatively unsaturated metal complex undergoes methylation reactions with a CH3+ source to form a new species with an Ir-CH3 bond. The redox-active Ir-CH3 complex performs the activation of CDCl3. The same activation reaction was also tested for other haloforms. In all types of reactions, the masked coordination site at the metal center and the electron reservoir behavior of the redox-active ligand are used for reactivity. Furthermore, we show that the aforementioned iridium(iii) complex performs redox-induced dihydrogen activation. This activation process was used to catalytically transfer the electrons and protons of dihydrogen to a substrate molecule. Crystallographic, spectroscopic, electrochemical, spectroelectrochemical and DFT methods were used to elucidate the geometric and the electronic structures of the metal complex in the various redox forms and to probe the mechanism of the investigated reactions. We demonstrate here how the cooperative behavior between a catalytically active metal center and a redox non-innocent ligand can be utilized to perform substrate bond activation and transformation.
- Optimization of Hg(II) adsorption on bio-apatite based materials using CCD-RSM design: characterization and mechanism studies. [Journal Article]
- JWJ Water Health 2019; 17(4):556-567
- Bio-apatite based materials were prepared from bovine bone wastes (BBW) by thermal treatments using a direct flame (BBS) and annealing at 500-1,100 °C (BB500-BB1100). These low-crystalline materials …
Bio-apatite based materials were prepared from bovine bone wastes (BBW) by thermal treatments using a direct flame (BBS) and annealing at 500-1,100 °C (BB500-BB1100). These low-crystalline materials were characterized by means of SEM, XRD, FTIR, TG, and pHPZC and were used for the adsorption of Hg(II) ions. A CCD-RSM design was used to optimize and analyze independent variables consisting of initial mercury concentration (10-100 mg L-1), pH (2-9), adsorbent mass (0.1-0.5 g), temperature (20-60 °C), and contact time (15-120 min). The results indicated that the order of the mercury uptakes for bio-apatite based adsorbents was BB500 > BB600 > BB800 > BB1100 > BBS > BBW. The dissolution-precipitation and ion-exchange reaction are the two dominant mechanisms for the removal of Hg(II) ions at low and high pH values, respectively. The CCD-RSM predicted maximum mercury adsorption of 99.99% under the optimal conditions of 51.31 mg L-1, 0.44 g, 6.5, 67.5 min, and 50 °C for initial mercury concentration, adsorbent mass, pH, contact time, and temperature, respectively. The findings of the present study revealed that the bio-apatite based materials, particularly BB500, are suitable and versatile adsorbents for the treatment of mercury-containing wastewater.
- 6-Shogaol protects against ischemic acute kidney injury by modulating NFκB and heme oxygenase-1 pathways. [Journal Article]
- AJAm J Physiol Renal Physiol 2019 Jul 17
- Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem without effective therapy. Ginger is one of the most widely consumed spices in the world and 6-Shogaol, a …
Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem without effective therapy. Ginger is one of the most widely consumed spices in the world and 6-Shogaol, a major Ginger metabolite, has anti-inflammatory effects in neuronal and epithelial cells. Here, we demonstrate that 6-Shogaol treatment protected against renal IR injury with decreased plasma creatinine, blood urea nitrogen and kidney NGAL mRNA synthesis compared to vehicle-treated mice subjected to renal IR. In addition, 6-Shogaol treatment reduced kidney inflammation (decreased pro-inflammatory cytokine and chemokine synthesis as well as neutrophil infiltration) and apoptosis (decreased TUNEL positive renal tubular cells) when compared to vehicle-treated mice subjected to renal IR. In cultured human and mouse kidney proximal tubule cells, 6-Shogaol significantly attenuated TNF-α induced inflammatory cytokine and chemokine mRNA synthesis. Mechanistically, 6-Shogaol significantly attenuated TNF-α induced NFκB activation in human renal proximal tubule cells by reducing IKKαβ/IκBα phosphorylation. Furthermore, 6-Shogaol induced a cytoprotective chaperone heme oxygenase-1 (HO-1) via p38 MAPK activation in vitro and in vivo. Consistent with these findings, pretreatment with a HO-1 inhibitor Zinc Protoporphyrin IX completely prevented 6-Shogaol-mediated protection against ischemic AKI in mice. Taken together, our studies show that 6-Shogaol protects against ischemic AKI by attenuating NFκB activation and inducing HO-1 expression. 6-Shogaol may provide a potential therapy for ischemic AKI during the perioperative period.
- Integration of colloidal PbS/CdS quantum dots with plasmonic antennas and superconducting detectors on a silicon nitride photonic platform. [Journal Article]
- NLNano Lett 2019 Jul 17
- Single-photon sources and detectors are indispensable building blocks for integrated quantum photonics, a research field that is seeing ever increasing interest for numerous applications. In this wor…
Single-photon sources and detectors are indispensable building blocks for integrated quantum photonics, a research field that is seeing ever increasing interest for numerous applications. In this work we implemented essential components for a Quantum Key Distribution (QKD) transceiver on a single photonic chip. Plasmonic antennas on top of silicon nitride waveguides provide Purcell enhancement with a concurrent increase of the count rate, speeding up the microsecond radiative lifetime of IR-emitting colloidal PbS/CdS Quantum Dots (QDs). The use of low-fluorescence silicon nitride with a waveguide loss smaller than 1 dB/cm, made it possible to implement high extinction ratio optical filters and low insertion loss spectrometers. Waveguide-coupled Superconducting Nanowire Single-Photon Detectors (SNSPDs) allow for low time-jitter single-photon detection. To showcase the performance of the components, we demonstrate on-chip lifetime spectroscopy of PbS/CdS QDs. The method developed in this paper is predicted to scale down to single QDs and newly developed emitters can be readily integrated on the chip-based platform.
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- Antibacterial Salinaphthoquinones from a Strain of the Bacterium Salinispora arenicola Recovered from the Marine Sediments of St. Peter and St. Paul Archipelago, Brazil. [Journal Article]
- JNJ Nat Prod 2019 Jul 17
- Salinaphthoquinones A-E (1-5) were isolated from a marine Salininispora arenicola strain, recovered from sediments of the St. Peter and St. Paul Archipelago, Brazil. The structures of the compounds w…
Salinaphthoquinones A-E (1-5) were isolated from a marine Salininispora arenicola strain, recovered from sediments of the St. Peter and St. Paul Archipelago, Brazil. The structures of the compounds were elucidated using a combination of spectroscopic (NMR, IR, HRESIMS) data, including single-crystal X-ray diffraction analysis. A plausible biosynthetic pathway for 1-5 is proposed. Compounds 1 to 4 displayed moderate activity against Staphylococcus aureus and Enterococcus faecalis with MIC values of 125 to 16 μg/mL.