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320,771 results
  • Regulated Acyl-CoA Synthetase Short-Chain Family Member 2 Accumulation during Spermatogenesis. [Journal Article]
    Cell J 2020; 22(1):66-70Goudarzi A, Amiri-Yekta A
  • CONCLUSIONS: The results of this study are in agreement with the idea that the major function of ACSS2 is to recycle acetate generated after histone deacetylation to regenerate acetyl-CoA which is required to maintain the steady state of histone acetylation. Thus, it is suggested that in spermatogenic cells, nuclear activity of ACSS2 maintains the acetate recycling until histone hyperacetylation, but disappears before the acetylation-dependent histone degradation.
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