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48,329 results
  • Pirouetting pigs: A large non-primate animal model based on unilateral 6-hydroxydopamine lesioning of the nigrostriatal pathway. [Journal Article]
  • BRBrain Res Bull 2018 Feb 17
  • Christensen AB, Sørensen JCH, … Bjarkam CR
  • CONCLUSIONS: Female Göttingen minipigs are susceptible to unilateral dopaminergic degeneration when properly injected unilaterally with sufficient amounts of 6-OHDA in the nigrostriatal pathway. The location of the 6-OHDA injections and thus the accuracy of the employed stereotaxy can be verified in vivo using MRI postoperatively. The injected minipigs display unilateral parkinsonism with a well-defined rotational response to amphetamine that may be ameliated by STN-DBS performed on the lesioned side. The response to apomorphine was, however, not consistent, illustrating that further work on this promising non-primate large animal model is needed, before it is fully similar to the established 6-OHDA models in other species.
  • Endogenous factors and mechanisms of renoprotection and renal repair. [Review]
  • EJEur J Clin Invest 2018 Feb 20
  • Perco P, Mayer G
  • CONCLUSIONS: We have generated a set of renoprotective factors based on literature information, which was functionally annotated and evaluated with respect to tested compounds in kidney disease and diabetes clinical trials. This article is protected by copyright. All rights reserved.
  • The Immunologic Paradoxes of IgG4-Related Disease. [Review]
  • CRClin Rev Allergy Immunol 2018 Feb 19
  • Xiao X, Lian M, … Ma X
  • IgG4-related disease (IgG4-RD), which usually occurs in middle-aged and elderly men, is a newly recognized fibroinflammatory condition characterized by swelling and sclerosis of involved organs, incr...
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