- Fertility-Related Perceptions and Impact on Romantic Relationships Among Adult Survivors of Childhood Cancer. [Journal Article]
- JAJ Adolesc Young Adult Oncol 2018 Feb 21
- CONCLUSIONS: Fertility-related perceptions varied among survivors, but the majority never underwent fertility testing. Uncertainty or concerns differed by current circumstances (e.g., wanting children and relationship status). Providers should routinely discuss potential infertility and offer testing throughout survivorship. A negative impact on romantic relationships may seem small, but should be considered for survivors who desire children and may discover they are infertile in the future.
- Pregnancy following robot-assisted laparoscopic partial cystectomy and gonadotropin-releasing hormone agonist treatment within three months in an infertile woman with bladder endometriosis. [Journal Article]
- TJTaiwan J Obstet Gynecol 2018; 57(1):153-156
- CONCLUSIONS: Robot-assisted complete resection of deep-infiltrating endometriosis and bladder repair immediately followed by GnRHa therapy and medical assistance improves reproductive outcomes efficiently in women with endometriosis-associated infertility.
- Efficacy and safety of Ding-Kun-Dan for female infertility patients with predicted poor ovarian response undergoing in vitro fertilization/intracytoplasmic sperm injection: study protocol for a randomized controlled trial. [Journal Article]
- TTrials 2018 Feb 20; 19(1):124
- CONCLUSIONS: IVF/ICSI is increasingly used to treat couples desiring a baby. Many of these women will have poor ovarian function. In China, DKD is commonly used for these patients prior to undergoing IVF/ICSI. There is no effective treatment for poor ovarian response in Western medicine currently. It is important, therefore, to undertake this randomized control trial to determine whether DKD is effective or not.
- Matching Trends for the Fellowship in Minimally Invasive Gynecologic Surgery (FMIGS) Since Participation in the National Residency Match Program (NRMP). [Journal Article]
- JMJ Minim Invasive Gynecol 2018 Feb 14
- CONCLUSIONS: Since the FMIGS programs began participating in the NRMP in 2014, the FMIGS match has been highly competitive as a gynecologic surgical subspecialty program, suggesting a high level of interest from residency graduates. This may reflect growing recognition that there is a body of knowledge that is unique to MIGS and that a well trained MIGS specialist can improve patient outcomes.
- Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. [Journal Article]
- HRHum Reprod Update 2018 Feb 13
- Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases that catalyze post-translational modifications of proteins. Together, they respond to metabolic challenges, inflammatory signals or hypo...
Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases that catalyze post-translational modifications of proteins. Together, they respond to metabolic challenges, inflammatory signals or hypoxic/oxidative stress, and are associated with aging and longevity. The role of Sirtuins in the regulation of fertility emerged in 2003 when a defective reproductive phenotype was observed in SIRT1-null mice. Although studies on Sirtuins in reproductive biology have been increasing in the last years, a recent comprehensive update on this issue is still lacking.
- History of estrogen in the male: an historical perspective. [Journal Article]
- BRBiol Reprod 2018 Feb 09
- Estrogens have traditionally been considered female hormones. Nevertheless, the presence of estrogenic substances in males has been known for over 90 years. Initial work with estrogen suggested that ...
Estrogens have traditionally been considered female hormones. Nevertheless, the presence of estrogenic substances in males has been known for over 90 years. Initial work with estrogen suggested that it was deleterious to male reproduction because exogenous estrogen treatments induced developmental abnormalities. However, demonstrations of estrogen synthesis in the testis and high concentrations of 17β-estradiol (E2) in rete testis fluid suggested that the female hormone might have a function in normal male reproduction. Identification of estrogen receptors and development of biological radioisotope methods to assess E2 binding revealed that the male reproductive tract expresses estrogen receptor extensively from the neonatal period to adulthood. This again indicated a role for estrogens in normal development, especially in the efferent ductules, whose epithelium is the first in the male reproductive tract to express estrogen receptor during development and a site of exceedingly high expression. In the 1990s, a paradigm shift occurred in our understanding of estrogen function in the male, ushered in by knockout mouse models where estrogen production or expression of its receptors were not present. These knockout animals revealed that estrogen's main receptor (ESR1) is essential for male fertility and development of efferent ductules, epididymis and prostate, and that loss of only the membrane fraction of ESR1 was sufficient to induce extensive male reproductive abnormalities and infertility. This review provides perspectives on the major discoveries and developments that led to our current knowledge of estrogen's importance in the male reproductive tract and shaped our evolving concept of estrogen's physiological role in the male.
- Association between vascular endothelial growth factor promoter polymorphisms and the risk of recurrent implantation failure. [Journal Article]
- ETExp Ther Med 2018; 15(2):2109-2119
- The objective of the present study was to investigate the association between recurrent implantation failure (RIF) and vascular endothelial growth factor (VEGF) gene polymorphisms that are associated...
The objective of the present study was to investigate the association between recurrent implantation failure (RIF) and vascular endothelial growth factor (VEGF) gene polymorphisms that are associated with various female infertility disorders. A total of 116 women diagnosed with RIF and 218 control subjects were genotyped for the VEGF -2578C>A, -1154G>A, -634C>G and 936C>T polymorphisms using a polymerase chain reaction-restriction fragment length polymorphism assay. The VEGF -2578AA genotype was associated with an increased prevalence (≥4) of RIF [adjusted odds ratio (AOR)=2.77; 95% confidence interval (CI)=1.10-7.02; P=0.031], whereas the VEGF -634CG+GG genotype was associated with an increased incidence of total RIF (AOR=2.03; 95% CI=1.02-4.05; P=0.044) and ≥4 RIF (AOR=3.16; 95% CI=1.19-8.37; P=0.021). The results of the haplotype analysis indicated that -2578A/-1154A/-634G/936C (AOR=1.76; 95% CI=1.03-3.00; P=0.040 for total RIF and AOR=2.11; 95% CI=1.12-3.97; P=0.021 for ≥4 RIF) was associated with the occurrence of RIF. In addition, it was revealed that there was a significant difference in serum prolactin level associated with the VEGF -634C>G polymorphism (P=0.013). Therefore the findings of the present study indicate that the VEGF -2578AA genotype, -634G allele and -2578A/-1154A/-634G/936C haplotype may be genetic markers for susceptibility to RIF. However, further studies on VEGF promoter polymorphisms that include an independent randomized-controlled population are required to confirm these results.
- Acquisition of oocyte competence to develop as an embryo: integrated nuclear and cytoplasmic events. [Journal Article]
- HRHum Reprod Update 2018 Feb 08
- Infertility affects ~7% of couples of reproductive age with little change in incidence in the last two decades. ART, as well as other interventions, have made major strides in correcting this conditi...
Infertility affects ~7% of couples of reproductive age with little change in incidence in the last two decades. ART, as well as other interventions, have made major strides in correcting this condition. However, and in spite of advancements in the field, the age of the female partner remains a main factor for a successful outcome. A better understanding of the final stages of gamete maturation yielding an egg that can sustain embryo development and a pregnancy to term remains a major area for improvement in the field. This review will summarize the major cellular and molecular events unfolding at the oocyte-to-embryo transition. We will provide an update on the most important processes/pathways currently understood as the basis of developmental competence, including the molecular processes involved in mRNA storage, its recruitment to the translational machinery, and its degradation. We will discuss the hypothesis that the translational programme of maternal mRNAs plays a key role in establishing developmental competence. These regulations are essential to assemble the machinery that is used to establish a totipotent zygote. This hypothesis further supports the view that embryogenesis begins during oogenesis. A better understanding of the events required for developmental competence will guide the development of novel strategies to monitor and improve the success rate of IVF. Using this information, it will be possible to develop new biomarkers that may be used to better predict oocyte quality and in selection of the best egg for IVF.
- Amenorrhoea and reversible infertility due to obstructive hydrocephalus: literature review and case report. [Journal Article]
- BJBr J Neurosurg 2018 Feb 12; :1-4
- CONCLUSIONS: Hydrocephalus can cause endocrine dysfunction, including amenorrhoea, which may reverse with CSF diversion. Therefore, cranial imaging is an important component in the evaluation of such endocrine abnormalities.
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- [Analysis on infertility status and influencing factors of female workers among reproductive age in China's nine industries]. [Journal Article]
- ZYZhonghua Yu Fang Yi Xue Za Zhi 2018 Feb 06; 52(2):134-140
- Objective: To investigate the infertility rate and influencing factors of female workers in China's nine industries.Methods:Using multi-stage sampling method, from January to Nove...
Objective: To investigate the infertility rate and influencing factors of female workers in China's nine industries.Methods:Using multi-stage sampling method, from January to November in 2016. A cross-sectional survey was conducted on the infertility of 33 685 female workers in the nine industries including medical and health, petrochemical, metallurgy, railway, machinery manufacturing and electronics,a questionnaire survey. First, three provincial capitals were randomly selected in seven regions. And then we consulted and communicated with the hospital of the provincial city's occupational disease prevention and treatment, marking and coding the target enterprise within its jurisdiction, In these enterprises, we randomly selected five companies. Finally, all women workers who meet the inclusion criteria were surveyed in those enterprises which were drawn. Use the"female workers reproductive health questionnaire" to collect female workers demographic status, occupational status and reproductive status and other data. The single factor analysis of infertility was performed by chi-square test. Multivariate analysis of infertility was carried out by logistic regression model.Results:The age of female workers in the nine industries was (35.98±7.98) years. The infertility rate for one year of female workers in typical industry was 24.81% (8 358/33 685), the infertility rate for two years being13.47% (4 537/33 685), the infertility rate for two years being 10.78% (3 632/33 685). Compared to the east China region, the infertility rate was the highest in the south region (OR=1.90, 95%CI:1.66-2.17). Compared to non-working women, the infertility rate was the highest among railroad (OR=1.68, 95%CI:1.43-1.98) and financial industries (OR=1.64, 95%CI:1.38-1.95). Occupational exposure to heavy metals (OR=1.15, 95%CI:1.04-1.27) and occupational exposure to hazardous physical factors (OR=1.09, 95%CI:1.01-1.17) were infertility risk factors.Conclusion:The infertility rate of female workers in the nineindustries was high. And the region, industry, occupational exposure to heavy metals and occupational exposure to hazardous physical factors, were independent risk factors for infertility.