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(Interstitial nephritis)
21,552 results
  • Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review. [Journal Article]
  • AJAm J Nephrol 2017 Jan 12; 45(2):160-169
  • Wanchoo R, Karam S, … Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors
  • CONCLUSIONS: In order to provide an extensive overview of the renal toxicities induced by these agents, a Medline search was conducted of published literature related to ipilimumab-, pembrolizumab-, and nivolumab-induced kidney toxicity. In addition, primary data from the initial clinical trials of these agents and the FDA adverse reporting system database were also reviewed to determine renal adverse events. Acute interstitial nephritis (AIN), podocytopathy, and hyponatremia were toxicities caused by ipilimumab. The main adverse effect associated with both the PD-1 inhibitors was AIN. The onset of kidney injury seen with PD-1 inhibitors is usually late (3-10 months) compared to CTLA-4 antagonists related renal injury, which happens earlier (2-3 months). PD-1 as opposed to CTLA-4 inhibitors has been associated with kidney rejection in transplantation. Steroids appear to be effective in treating the immune-related adverse effects noted with these agents. Key Message: Although initially thought to be rare, the incidence rates of renal toxicities might be higher (9.9-29%) as identified by recent studies. As a result, obtaining knowledge about renal toxicities of immune checkpoint inhibitors is extremely important.
  • [Kidney disease in HIV-infected patient]. [Journal Article]
  • WLWiad Lek 2016; 69(5):725-728
  • Matuszkiewicz-Rowińska J, Wieliczko M
  • In the developed countries with an access to highly active antiretroviral therapy (HAART), the spectrum of renal complications observed in patients infected with HIV has shifted from HIV-associated k...
  • [Acute tubule-interstitial nephritis]. [Journal Article]
  • WLWiad Lek 2016; 69(5):714-716
  • Niemczyk L, Jędras M
  • Acute tubule-interstitial nephritis is a heterogeneous group of inflammatory diseases which affect renal parenchyma and tubules, mostly as a result of the immune-mediated injury. They are the importa...
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