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24,241 results
  • Pharmacoeconomic Review Report: Edoxaban (Lixiana) [BOOK]
  • BOOKCanadian Agency for Drugs and Technologies in Health: Ottawa (ON)
  • Edoxaban (Lixiana) is indicated for the treatment of venous thromboembolism (VTE) and the prevention of recurrent VTE.1 The dose is 60 mg once daily. The cost per day of treatment with edoxaban is $2...
  • Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock. [Review]
  • CDCochrane Database Syst Rev 2018 Dec 10; 12:CD010593
  • Li D, Li X, … Xia Y
  • CONCLUSIONS: No studies compared liberal versus conservative fluid therapy in adults. Low- to high-quality evidence indicates that liberal fluid therapy might increase mortality among children with sepsis or septic shock in hospital and at four-week follow-up. It is uncertain whether there are any differences in adverse events between liberal and conservative fluid therapy because the evidence is of low quality. Trials including adults, patients in other settings, and patients with a broader spectrum of pathogens are needed. Once published and assessed, three ongoing studies may alter the conclusions of this review.
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