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(Irritable Bowel Syndrome)
13,997 results
  • StatPearls: Probiotics [BOOK]
    StatPearls Publishing: Treasure Island (FL) Shahrokhi Mahsa M Saint James School of Medicine Nagalli Shivaraj S Yuma Regional Medical Center BOOK
  • There is a range of diseases that are associated with the intestinal tract, causing alterations in bowel habits. Usually, due to a particular inciting event, patients get changes in the microbes found in the gut, leading to significantly distressing various gut disorders ranging from antibiotic-associated diarrhea to chronic irritable bowel syndrome.[1] Yet, these are just some examples of the ma…
  • Low-FODMAP Diet for Irritable Bowel Syndrome: What We Know and What We Have Yet to Learn. [Journal Article]
    Annu Rev Med 2020; 71:303-314Liu J, Chey WD, … Eswaran S
  • Irritable bowel syndrome (IBS) is the most prevalent of gastrointestinal (GI) conditions, affecting millions of people worldwide. Given that most IBS patients associate their GI symptoms with eating food, specific dietary manipulation has become an attractive treatment strategy. A diet low in FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) has generated the gre…
  • Plecanatide for the treatment of constipation-predominant irritable bowel syndrome. [Journal Article]
    Expert Rev Gastroenterol Hepatol 2020Miner PB
  • As an analogue of uroguanylin plecanatide binds to the Guanylate Cyclase-C receptor activating fluid and ion secretion in the small intestine with the same pH-dependent binding kinetics as the natural ligand. Plecanatide has been FDA approved as safe and effective for the indications of Chronic Idiopathic Constipation (CIC) and Irritable Bowel Syndrome with Constipation (IBS-C).Areas Covered: All…
  • Blockade of BDNF Signaling Attenuates Chronic Visceral Hypersensitivity in an IBS-like Rat Model. [Journal Article]
    Eur J Pain 2020Fan F, Tang Y, … Lin C
  • CONCLUSIONS: NMS caused visceral hypersensitivity and increased synaptic activity by activating BDNF-TrkB-PKMζ signaling in the thoracolumbar spinal cord of adult rats. PKMζ was able to potentiate AMPA receptor (AMPAR)-mediated sEPSCs in NMS rats. ANA-12 attenuated visceral hypersensitivity and synaptic activity by blocking BDNF/TrkB signaling in NMS rats.ANA-12 attenuates visceral hypersensitivity via BDNF-TrkB-PKMζ signaling and reduces synaptic activity through AMPARs in NMS rats. This knowledge suggests that ANA-12 could represent an interesting novel therapeutic medicine for chronic visceral hypersensitivity.
  • StatPearls: Alosetron [BOOK]
    StatPearls Publishing: Treasure Island (FL) Butt Ifrah I Aventura Hospital and Medical Center Kasmin Franklin F Mount Sinai School of Medicine BOOK
  • Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional disorder of the gastrointestinal tract (GI), which manifests with chronic abdominal pain and diarrhea. It is a condition that negatively impacts the quality of life of individuals affected and contributes to increased healthcare costs.[1] First-line therapy for the management of IBS-D is usually diet and lifestyle modifications…
  • Understanding the Scope of Do-It-Yourself Fecal Microbiota Transplant. [Journal Article]
    Am J Gastroenterol 2020Ekekezie C, Perler BK, … Kelly CR
  • CONCLUSIONS: DIY-FMT is being used for many indications, including those for which there is little evidence. There was a high self-reported success rate among respondents with few adverse events. There is a need for increased awareness around DIY-FMT and research around this phenomenon, which may impact public health.
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