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Unbound Medicine.
(Isaac's syndrome)
588 results
  • Adapting Medication for Type 2 Diabetes to a Low Carbohydrate Diet. [Review]
    Front Nutr. 2021; 8:688540.Cucuzzella M, Riley K, Isaacs D
  • Healthcare professionals in the primary care setting need to be competent to safely adapt diabetes medications when patients with Type 2 Diabetes (T2D) alter their diet. Safe prescribing practice is supported through an understanding of the clinical evidence, basic science, and pharmacology of medications. This review article supports clinicians in the practical application of this knowledge to a…
  • Mercury poisoning complicated by acquired neuromyotonia syndrome: A case report. [Case Reports]
    Medicine (Baltimore). 2021 Aug 13; 100(32):e26910.Ran E, Wang M, … Liu Y
  • CONCLUSIONS: Acquired neuromyotonia syndrome is a rare disorder caused by the hyperexcitability of peripheral nerves, resulting in spontaneous and continuous muscle contraction. Mercury poisoning should be considered in patients with neuromyotonia syndrome. Early detection of mercury poisoning can prevent unnecessary examinations and treatments.
  • SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants. [Journal Article]
    PLoS Med. 2021 07; 18(7):e1003656.Tea F, Ospina Stella A, … Turville SG
  • The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody neutralization response and its evasion by emerging viral variants and variant of concern (VOC) are unknown, but critical to understand reinfection risk and breakthrough infection following vaccination. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus-cell fusion, an…
  • Prostate Cancer Predisposition. [Review]
    Urol Clin North Am. 2021 Aug; 48(3):283-296.Bhanji Y, Isaacs WB, … Cooney KA
  • The identification and characterization of alterations in prostate cancer (PCa)-predisposing genes can help to inform screening strategies in undiagnosed men and treatment options in men in both the clinically localized and in the metastatic setting. This review provides an overview of the genetic basis underlying hereditary predisposition to PCa, the current role of genetics and PCa risk assessm…
  • Demystifying the spontaneous phenomena of motor hyperexcitability. [Review]
    Clin Neurophysiol. 2021 Aug; 132(8):1830-1844.Bashford J, Chan WK, … Shaw CE
  • Possessing a discrete functional repertoire, the anterior horn cell can be in one of two electrophysiological states: on or off. Usually under tight regulatory control by the central nervous system, a hierarchical network of these specialist neurons ensures muscular strength is coordinated, gradated and adaptable. However, spontaneous activation of these cells and their axons can result in abnorm…
  • An Unusual Case of Muscle Twitching: Its LGI1. [Case Reports]
    Neurol India. 2021 Mar-Apr; 69(2):493-494.Tomar LR, Shah DJ, … Agrawal CS
  • A 50-year-old male, presented with a two-months history of ascending paresthesias, with continuous twitchings over the body, associated with insomnia. His electromyography (EMG) revealed neuromyotonia and was diagnosed as a case of peripheral nerve hyperexcitability (PNH) syndrome due to Leucin-rich glioma-inactivated 1 (LGI1) antibody. He showed significant improvement with intravenous immunoglo…
  • Clinical Correlates of Health-Related Quality of Life in Adults With Chronic Tic Disorder. [Journal Article]
    Front Psychiatry. 2021; 12:619854.Isaacs DA, Riordan HR, Claassen DO
  • Tics are the hallmark feature of Tourette syndrome (TS), but psychiatric and sensory symptoms are widely prevalent and increasingly recognized as core manifestations of the disorder. Accumulating evidence suggests that these psychiatric and sensory symptoms exert greater influence on quality of life (QOL) than tics themselves. However, much remains uncertain about determinants of QOL in TS due to…
  • Secreted Signaling Molecules at the Neuromuscular Junction in Physiology and Pathology. [Review]
    Int J Mol Sci. 2021 Feb 28; 22(5)Ohkawara B, Ito M, Ohno K
  • : Signal transduction at the neuromuscular junction (NMJ) is affected in many human diseases, including congenital myasthenic syndromes (CMS), myasthenia gravis, Lambert-Eaton myasthenic syndrome, Isaacs' syndrome, Schwartz-Jampel syndrome, Fukuyama-type congenital muscular dystrophy, amyotrophic lateral sclerosis, and sarcopenia. The NMJ is a prototypic cholinergic synapse between the motor neur…
  • Case report: Isolated muscle neuromyotonia, as presenting feature of Isaacs' syndrome. [Case Reports]
    J Neuroimmunol. 2021 04 15; 353:577491.Samogalskyi V, Alcalay Y, … Gilad R
  • An autoimmune form of Isaacs' syndrome is commonly associated with VGKC complex antibodies and characterized by continuous muscle activity of extremity muscles. Here, we describe a CASPR2 and LGI1 positive patient with neuromyotonia clinically and electrophysiologically isolated to gastrocnemius muscles only. IVIG course and plasma exchange were ineffective, but symptoms significantly improved af…
  • Anesthetic Management of Robotic Thymectomy in a Patient With Morvan Syndrome: A Case Report. [Case Reports]
    A A Pract. 2021 Jan 14; 15(1):e01383.Royston SE, Hartigan PM
  • Morvan syndrome (MvS) is a rare acquired paraneoplastic autoimmune neuromyotonia with central and autonomic nervous system involvement that has been incompletely described in the literature. We describe the successful administration of general anesthesia for robotic thymectomy to an MvS patient with severe encephalopathy, cardiac dysautonomia, and peripheral nerve hyperexcitation. Importantly, th…
  • Mild cognitive impairment: the Manchester consensus. [Journal Article]
    Age Ageing. 2021 01 08; 50(1):72-80.Dunne RA, Aarsland D, … Burns A
  • Given considerable variation in diagnostic and therapeutic practice, there is a need for national guidance on the use of neuroimaging, fluid biomarkers, cognitive testing, follow-up and diagnostic terminology in mild cognitive impairment (MCI). MCI is a heterogenous clinical syndrome reflecting a change in cognitive function and deficits on neuropsychological testing but relatively intact activit…
  • The Role of Type I Interferons in the Pathogenesis and Treatment of COVID-19. [Review]
    Front Immunol. 2020; 11:595739.Schreiber G
  • Type I interferons (IFN-I) were first discovered over 60 years ago in a classical experiment by Isaacs and Lindenman, who showed that IFN-Is possess antiviral activity. Later, it became one of the first approved protein drugs using heterologous protein expression systems, which allowed its large-scale production. It has been approved, and widely used in a pleiotropy of diseases, including multipl…
  • Ocular neuromyotonia of the right third cranial nerve. [Case Reports]
    J AAPOS. 2020 10; 24(5):298-298.e1.Alcubierre R, Alejaldre A
  • Ocular neuromyotonia is a rare disorder of the oculomotor nerves caused by chronic damage to the nerve, usually secondary to previous irradiation or longstanding compression. We present the case of a 40-year-old man who had received proton beam therapy for a right cavernous sinus chondrosarcoma 15 years earlier. He developed intermittent episodes of self-limited horizontal diplopia, which occurre…
  • Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell-cell fusion. [Journal Article]
    J Gen Virol. 2021 01; 102(1)Thakur N, Conceicao C, … Bailey D
  • Although enveloped viruses canonically mediate particle entry through virus-cell fusion, certain viruses can spread by cell-cell fusion, brought about by receptor engagement and triggering of membrane-bound, viral-encoded fusion proteins on the surface of cells. The formation of pathogenic syncytia or multinucleated cells is seen in vivo, but their contribution to viral pathogenesis is poorly und…
  • A Rare Case of Peripheral Nerve Hyperexcitability in Childhood: Isaacs Syndrome. [Case Reports]
    J Pediatr Neurosci. 2020 Apr-Jun; 15(2):153-156.Kanmaz S, Özcan M, … Tekgül H
  • Isaacs syndrome is rare disorder with peripheral nerve hyperexcitability syndromes with acquired neuromyotonia in childhood. We present a 13-year-old girl with muscle stiffness and neuromyotonia diagnosed Isaac syndrome with spontaneous discharge potentials on motor unit in electromyography and the diagnosis supported by the presence of antinuclear antibodies. A successful treatment was obtained …
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