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23,593 results
  • Mutational signatures: experimental design and analytical framework. [Review]
    Genome Biol 2020; 21(1):37Koh G, Zou X, Nik-Zainal S
  • Mutational signatures provide a powerful alternative for understanding the pathophysiology of cancer. Currently, experimental efforts aimed at validating and understanding the etiologies of cancer-derived mutational signatures are underway. In this review, we highlight key aspects of mutational signature experimental design and describe the analytical framework. We suggest guidelines and quality …
  • Inflammation-Modulating Hydrogels for Osteoarthritis Cartilage Tissue Engineering. [Review]
    Cells 2020; 9(2)Koh RH, Jin Y, … Hwang NS
  • Osteoarthritis (OA) is the most common form of the joint disease associated with age, obesity, and traumatic injury. It is a disabling degenerative disease that affects synovial joints and leads to cartilage deterioration. Despite the prevalence of this disease, the understanding of OA pathophysiology is still incomplete. However, the onset and progression of OA are heavily associated with the in…
  • Unique Pro-Inflammatory Response of Macrophages during Apoptotic Cancer Cell Clearance. [Journal Article]
    Cells 2020; 9(2)Mendoza-Reinoso V, Baek DY, … Roca H
  • The clearance of apoptotic cells by macrophages (efferocytosis) is crucial to maintain normal tissue homeostasis; however, efferocytosis of cancer cells frequently results in inflammation and immunosuppression. Recently, we demonstrated that efferocytosis of apoptotic prostate cancer cells by bone marrow-derived macrophages induced a pro-inflammatory response that accelerated metastatic tumor gro…
  • Nanostructured MoO2/MoS2/MoP heterojunction electrocatalyst for hydrogen evolution reaction. [Journal Article]
    Nanotechnology 2020Huang L, Yang Y, … Liu Z
  • Electrocatalytic production of hydrogen from water is considered to be a promising and sustainable strategy. In this work, the low-cost nanostructured MoO2/MoS2/MoP heterojunction is successfully synthesized by phosphorization of the pre-prepared urchin-like MoO2/MoS2 nanospheres as the stable, high efficient electrocatalysis for HER. The MoO2/MoS2/MoP-800 (MoO2/MoS2 nanospheres are phosphated at…
  • Trans-Coracoacromial Ligament Glenohumeral Injection with Arthroscopic Confirmation. [Journal Article]
    Arthroscopy 2020Shao X, Chen J, … Wang J
  • CONCLUSIONS: The trans-coracoacromial ligament injection technique demonstrated high success rate (91.8%) in anesthetized patients about to undergo arthroscopy, while the failed injections were mainly because the needle inserted into the subscapularis or labrum. This technique can be used for awake patients in multiple settings with different diagnoses.
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