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Unbound Medicine.
(Kashin Beck disease)
371 results
  • Selenium: A Trace Element for a Healthy Skeleton - A Narrative Review. [Journal Article]
    Endocr Metab Immune Disord Drug Targets. 2020 Jun 27 [Online ahead of print]Vescini F, Chiodini I, … Falchetti A
  • Inadequate serum selenium levels may delay the growth and the physiological changes in bone metabolism. In humans, reduced serum selenium concentrations are associated with both increased bone turnover and reduced bone mineral density. Moreover, a reduced nutritional intake of selenium may lead to an increased risk of bone disease. Therefore, selenium is an essential nutrient playing a role in bo…
  • Effects of methylation of deiodinase 3 gene on gene expression and severity of Kashin-Beck disease. [Journal Article]
    J Cell Physiol. 2020 May 27 [Online ahead of print]Li Z, Zhang D, … Xiong Y
  • Kashin-Beck disease (KBD) is a complex endemic osteoarthropathy, which mainly occurs in the northeast to southwest China. Iodothyronine deiodinases 3 (DIO3) is one of the selenoproteins, which is closely related to bone metabolism and unclear to KBD. This study aims to investigate the role and associated mechanisms of methylation and expression of DIO3 with disease severity in patients with KBD. …
  • Cytotoxic Properties of HT-2 Toxin in Human Chondrocytes: Could T3 Inhibit Toxicity of HT-2? [Journal Article]
    Toxins (Basel). 2019 11 15; 11(11)Zhang F, Lammi MJ, … Guo X
  • Thyroid hormone triiodothyronine (T3) plays an important role in coordinated endochondral ossification and hypertrophic differentiation of the growth plate, while aberrant thyroid hormone function appears to be related to skeletal malformations, osteoarthritis, and Kashin-Beck disease. The T-2 toxin, present extensively in cereal grains, and one of its main metabolites, HT-2 toxin, are hypothesiz…
  • The effectiveness of treatments for Kashin-Beck disease: a systematic review and network meta-analysis. [Meta-Analysis]
    Clin Rheumatol. 2019 Dec; 38(12):3595-3607.Zou K, Hu J, … Zhang W
  • CONCLUSIONS: Selenium supplement has demonstrated some benefits for structural improvement of the disease in children. Chondroitin, glucosamine, IAH and nonsteroid anti-inflammatory drugs are effective for symptom improvements of KBD in adults. Evidence of surgical and complementary treatments for symptoms and aspirin and vitamin C for structure has yet to be established.Key Points• There were 23 nutraceuticals, pharmaceuticals and surgical and complementary treatments assessed for Kashin-Beck disease (KBD) in randomised trials.• Among the 23 treatments, chondroitin, glucosamine, IAH and non-steroid anti-inflammatory drugs are more effective than placebo to relieve symptoms for adults with KBD.• Selenium supplement is more effective than placebo for radiographic improvement in children or adolescents.• The efficacy of surgeries, aspirin, vitamin C and complementary treatments for KBD has not been established yet.
  • The role of the fibroblast growth factor family in bone-related diseases. [Review]
    Chem Biol Drug Des. 2019 10; 94(4):1740-1749.Wang J, Liu S, … Yi Z
  • Fibroblast growth factor (FGF) family members are important regulators of cell growth, proliferation, differentiation, and regeneration. The abnormal expression of certain FGF family members can cause skeletal diseases, including achondroplasia, craniosynostosis syndrome, osteoarthritis, and Kashin-Beck disease. Accumulating evidence shows that FGFs play a crucial role in the growth and prolifera…
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