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2,957 results
  • Molecular Evidence for Differential Long-term Outcomes of Early Life Severe Acute Malnutrition. [Journal Article]
  • EEBioMedicine 2017 Mar 08
  • Sheppard A, Ngo S, … Forrester T
  • CONCLUSIONS: These findings suggest persistent developmental influences on adult physiology in survivors of SAM. Since children who develop marasmus have lower birth weights and after rehabilitation have different intermediary metabolism, these studies provide further support for persistent developmentally-induced phenomena mediated by epigenetic processes affecting both the infant response to acute malnutrition and later life consequences.
  • Risk factors for death in children during inpatient treatment of severe acute malnutrition: a prospective cohort study. [Journal Article]
  • AJAm J Clin Nutr 2017; 105(2):494-502
  • Rytter MJ, Babirekere-Iriso E, … Friis H
  • CONCLUSIONS: Refeeding syndrome may occur in children who are treated for malnutrition, even with moderately low plasma phosphate, and, in particular, in children with edematous malnutrition. The replacement of F-75 with unfortified rice porridge is associated with increased risk of death, which is possibly mediated by lowering plasma phosphate. The identified clinical risk factors may potentially improve the triage of children with malnutrition. This trial was registered at as ISRCTN55092738.
  • Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition. [Journal Article]
  • JNJ Nutr 2016; 146(12):2436-2444
  • Di Giovanni V, Bourdon C, … Bandsma RH
  • CONCLUSIONS: Children with kwashiorkor were metabolically distinct from those with marasmus, and were more prone to severe metabolic disruptions. Children with SAM showed metabolic profiles that were profoundly different from stunted and nonstunted controls, even after clinical stabilization. Therefore, metabolic recovery in children with SAM likely extends beyond discharge, which may explain the poor long-term outcomes in these children. This trial was registered at as ISRCTN13916953.
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