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353 results
  • A Systematic Review on the Possible Relationship Between Bilingualism, Cognitive Decline, and the Onset of Dementia. [Review]
    Behav Sci (Basel) 2019; 9(7)van den Noort M, Vermeire K, … Lim S
  • A systematic review was conducted to investigate whether bilingualism has a protective effect against cognitive decline in aging and can protect against dementia. We searched the Medline, ScienceDirect, Scopus, and ERIC databases with a cut-off date of 31 March, 2019, thereby following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) protocol. Our …
  • Fundamentals of Clinical Data Science: Data Sources [BOOK]
    Springer: Cham (CH)Kubben P, Dumontier M, … Dekker AKubben PBOOK
  • There are many sources that relevant data for clinical data science can originate from. The brief overview in this chapter highlights the most frequent sources, but is definitely not exhaustive. The goal of this chapter is to provide an introduction to the most common data sources and to familiarize the reader with basic terminology in this context, in order to more easily understand discussions …
  • Detectability of biosignatures in a low-biomass simulation of martian sediments. [Journal Article]
    Sci Rep 2019; 9(1):9706Stevens AH, McDonald A, … Cockell CS
  • Discovery of a remnant habitable environment by the Mars Science Laboratory in the sedimentary record of Gale Crater has reinvigorated the search for evidence of martian life. In this study, we used a simulated martian mudstone material, based on data from Gale Crater, that was inoculated and cultured over several months and then dried and pressed. The simulated mudstone was analysed with a range…
  • Stereotactic Radiosurgery in Large Intracranial Meningiomas: A Systematic Review. [Review]
    World Neurosurg 2019; 129:269-275Fatima N, Meola A, … Chang SD
  • Gross total resection of large intracranial meningiomas (LIMs) can be challenging and cause significant morbidity and mortality. The aim of this systematic review is to determine the clinical effectiveness and safety of stereotactic radiosurgery (SRS) either as primary or adjuvant therapy for LIMs with tumors ≥2.5 cm in maximum dimension (tumor volume ≥8.1 cm3). A total of 452 tumors in 496 patie…
  • Laboratory information management software for engineered mini-protein therapeutic workflow. [Journal Article]
    BMC Bioinformatics 2019; 20(1):343Brusniak MY, Ramos H, … Olson JM
  • Protein based therapeutics are one of the fastest growing classes of novel medical interventions in areas such as cancer, infectious disease, and inflammation. Protein engineering plays an important role in the optimization of desired therapeutic properties such as reducing immunogenicity, increasing stability for storage, increasing target specificity, etc. One category of protein therapeutics i…
  • Immunoprofiling of Breast Cancer Antigens Using Antibodies Derived from Local Lymph Nodes. [Journal Article]
    Cancers (Basel) 2019; 11(5)Young AR, Duarte JDG, … Meeusen E
  • Tumor antigens are responsible for initiating an immune response in cancer patients, and their identification may provide new biomarkers for cancer diagnosis and targets for immunotherapy. The general use of serum antibodies to identify tumor antigens has several drawbacks, including dilution, complex formation, and background reactivity. In this study, antibodies were generated from antibody-sec…
  • Time to positivity (TTP) of neonatal blood cultures: a trend analysis over a decade from Ireland. [Journal Article]
    J Matern Fetal Neonatal Med 2019; :1-7Huggard D, Powell J, … Philip RK
  • CONCLUSIONS: Duration of this study exceeds that of most of the neonatal blood culture TTP analysis published to-date. A shorter TTP is an important adjunct to suggest the growth of a pathogenic organism while managing suspected neonatal sepsis. TTP if < 24 h per se would not necessarily confirm the growth of a highly pathogenic organism; however, if a positive growth is likely to happen for a significant neonatal pathogen, in more than 98% the TTP would be within 24 h. This offers the clinician more of negative predictive value than a positive one; when there is no growth in BC. Our observation on TTP reiterate the National Institute of Health and Care Excellence (NICE) guideline of discontinuation of empiric antibiotics after 36 h in and clinically well and BC negative newborn infants.
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