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374 results
  • Correcting an instance of synthetic lethality with a pro-survival sequence. [Journal Article]
    Biochim Biophys Acta Mol Cell Res. 2020 Sep; 1867(9):118734.Zhou DR, Miller KA, … Greenwood MT
  • A human cDNA encoding the LIM domain containing 194 amino acid cysteine and glycine rich protein 3 (CSRP3) was identified as a BAX suppressor in yeast and a pro-survival sequence that abrogated copper mediated regulated cell death (RCD). Yeast lacks a CSRP3 orthologue but it has four LIM sequences, namely RGA1, RGA2, LRG1 and PXL1. These are known regulators of stress responses yet their roles in…
  • Direct Measurement of the Visible to UV Photodissociation Processes for the PhotoCORM TryptoCORM. [Journal Article]
    Chemistry. 2020 Apr 10 [Online ahead of print]Dessent CEH, Cercola R, … Fairlamb IJS
  • PhotoCORMs are light-triggered compounds that release CO for medical applications. Here, we apply laser spectroscopy in the gas phase to TryptoCORM, a known photoCORM that has been shown to destroy Escherichia coli upon visible-light activation. Our experiments allow us to map TryptoCORM's photochemistry across a wide wavelength range by using novel laser-interfaced mass spectrometry (LIMS). LIMS…
  • Selective exposure shapes the Facebook news diet. [Journal Article]
    PLoS One. 2020; 15(3):e0229129.Cinelli M, Brugnoli E, … Scala A
  • The social brain hypothesis approximates the total number of social relationships we are able to maintain at 150. Similar cognitive constraints emerge in several aspects of our daily life, from our mobility to the way we communicate, and might even affect the way we consume information online. Indeed, despite the unprecedented amount of information we can access online, our attention span still r…
  • Active sorting of orbital angular momentum states of light with a cascaded tunable resonator. [Journal Article]
    Light Sci Appl. 2020; 9:10.Wei S, Earl SK, … Yuan XC
  • The orbital angular momentum (OAM) of light has been shown to be useful in diverse fields ranging from astronomy and optical trapping to optical communications and data storage. However, one of the primary impediments preventing such applications from widespread adoption is the lack of a straightforward and dynamic method to sort incident OAM states without altering the states. Here, we report a …
  • Emergency preparedness, resilience and response guidance for UK hospital transfusion teams. [Journal Article]
    Transfus Med. 2020 Jun; 30(3):177-185.Doughty H, Chowdhury F, National Blood Transfusion Committee Emergency Planning Working Group
  • CONCLUSIONS: Transfusion teams have an important role in ensuring continuity of transfusion support. Teams should develop their EPRR plans based on local plans and national guidance. Emergency preparedness should include post-incident debriefing for ongoing staff support and future service improvement.
  • FGF13 promotes metastasis of triple-negative breast cancer. [Journal Article]
    Int J Cancer. 2020 Jul 01; 147(1):230-243.Johnstone CN, Pattison AD, … Beilharz TH
  • Triple-negative breast cancer (TNBC) represents 10-20% of all human ductal adenocarcinomas and has a poor prognosis relative to other subtypes, due to the high propensity to develop distant metastases. Hence, new molecular targets for therapeutic intervention are needed for TNBC. We recently conducted a rigorous phenotypic and genomic characterization of four isogenic populations of MDA-MB-231 hu…
  • Genome analysis and knowledge-driven variant interpretation with TGex. [Journal Article]
    BMC Med Genomics. 2019 12 30; 12(1):200.Dahary D, Golan Y, … Fishilevich S
  • CONCLUSIONS: TGex is an innovative tool for the annotation, analysis and prioritization of coding and non-coding genomic variants. It provides access to an extensive knowledgebase of genomic annotations, with intuitive and flexible configuration options, allows quick adaptation, and addresses various workflow requirements. It thus simplifies and accelerates variant interpretation in clinical genetics workflows, with remarkable diagnostic yield, as exemplified in the described use cases. TGex is available at http://tgex.genecards.org/.
  • Recursive patterns in online echo chambers. [Journal Article]
    Sci Rep. 2019 12 27; 9(1):20118.Brugnoli E, Cinelli M, … Scala A
  • Despite their entertainment oriented purpose, social media changed the way users access information, debate, and form their opinions. Recent studies, indeed, showed that users online tend to promote their favored narratives and thus to form polarized groups around a common system of beliefs. Confirmation bias helps to account for users' decisions about whether to spread content, thus creating inf…
  • A prospective compound screening contest identified broader inhibitors for Sirtuin 1. [Journal Article]
    Sci Rep. 2019 12 20; 9(1):19585.Chiba S, Ohue M, … Sekijima M
  • Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library containing 2.5 million compounds using in silico methods and scoring. Our aim was to identify target enzyme inhibitors and to benchmark computer-aided drug …
  • LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA. [Journal Article]
    Nucleic Acids Res. 2019 11 04; 47(19):10357-10372.Izumikawa K, Ishikawa H, … Takahashi N
  • Activation of ribosomal RNA (rRNA) synthesis is pivotal during cell growth and proliferation, but its aberrant upregulation may promote tumorigenesis. Here, we demonstrate that the candidate oncoprotein, LYAR, enhances ribosomal DNA (rDNA) transcription. Our data reveal that LYAR binds the histone-associated protein BRD2 without involvement of acetyl-lysine-binding bromodomains and recruits BRD2 …
  • A Systematic Review on the Possible Relationship Between Bilingualism, Cognitive Decline, and the Onset of Dementia. [Review]
    Behav Sci (Basel). 2019 Jul 23; 9(7)van den Noort M, Vermeire K, … Lim S
  • A systematic review was conducted to investigate whether bilingualism has a protective effect against cognitive decline in aging and can protect against dementia. We searched the Medline, ScienceDirect, Scopus, and ERIC databases with a cut-off date of 31 March, 2019, thereby following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) protocol. Our …
  • Fundamentals of Clinical Data Science: Data Sources [BOOK]
    . Springer: Cham (CH)Kubben P, Dumontier M, … Dekker AKubben PBOOK
  • There are many sources that relevant data for clinical data science can originate from. The brief overview in this chapter highlights the most frequent sources, but is definitely not exhaustive. The goal of this chapter is to provide an introduction to the most common data sources and to familiarize the reader with basic terminology in this context, in order to more easily understand discussions …
  • Detectability of biosignatures in a low-biomass simulation of martian sediments. [Journal Article]
    Sci Rep. 2019 07 04; 9(1):9706.Stevens AH, McDonald A, … Cockell CS
  • Discovery of a remnant habitable environment by the Mars Science Laboratory in the sedimentary record of Gale Crater has reinvigorated the search for evidence of martian life. In this study, we used a simulated martian mudstone material, based on data from Gale Crater, that was inoculated and cultured over several months and then dried and pressed. The simulated mudstone was analysed with a range…
  • Stereotactic Radiosurgery in Large Intracranial Meningiomas: A Systematic Review. [Journal Article]
    World Neurosurg. 2019 Sep; 129:269-275.Fatima N, Meola A, … Chang SD
  • Gross total resection of large intracranial meningiomas (LIMs) can be challenging and cause significant morbidity and mortality. The aim of this systematic review is to determine the clinical effectiveness and safety of stereotactic radiosurgery (SRS) either as primary or adjuvant therapy for LIMs with tumors ≥2.5 cm in maximum dimension (tumor volume ≥8.1 cm3). A total of 452 tumors in 496 patie…
  • Laboratory information management software for engineered mini-protein therapeutic workflow. [Journal Article]
    BMC Bioinformatics. 2019 Jun 17; 20(1):343.Brusniak MY, Ramos H, … Olson JM
  • Protein based therapeutics are one of the fastest growing classes of novel medical interventions in areas such as cancer, infectious disease, and inflammation. Protein engineering plays an important role in the optimization of desired therapeutic properties such as reducing immunogenicity, increasing stability for storage, increasing target specificity, etc. One category of protein therapeutics i…
  • Immunoprofiling of Breast Cancer Antigens Using Antibodies Derived from Local Lymph Nodes. [Journal Article]
    Cancers (Basel). 2019 May 16; 11(5)Young AR, Duarte JDG, … Meeusen E
  • Tumor antigens are responsible for initiating an immune response in cancer patients, and their identification may provide new biomarkers for cancer diagnosis and targets for immunotherapy. The general use of serum antibodies to identify tumor antigens has several drawbacks, including dilution, complex formation, and background reactivity. In this study, antibodies were generated from antibody-sec…
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