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16,289 results
  • Interactions Between Sleep Disruption, Motor Learning, and p70 S6 Kinase 1 Signaling. [Journal Article]
    Sleep 2019Kam K, Kang M, … Varga AW
  • Offline gains in motor performance after initial motor learning likely depend on sleep, but the molecular mechanisms by which this occurs are understudied. Regulation of mRNA translation via p70 S6 kinase 1 (S6K1) signaling represents one potential mechanism, as protein synthesis is thought to be increased during sleep compared to wake and is necessary for several forms of long-term memory. Using…
  • Anti IL-17 in psoriasis. [Journal Article]
    Expert Rev Clin Immunol 2019Ly K, Smith MP, … Bhutani T
  • Introduction: Psoriasis is a chronic, immune-mediated disease with significant associated comorbidities. Its pathogenesis is likely multifactorial, however, the interleukin-23/T helper 17 pathway has been identified as a critical axis in its pathogenesis. Interleukin-17A is the primary effector of this pathway and overexpression of IL-17A results in epidermal hyperplasia and an overly robust infl…
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