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(Lambert Eaton myasthenic syndrome Eaton Lambert syndrome)
1,108 results
  • Lambert-Eaton Myasthenic Syndrome, Botulism, and Immune Checkpoint Inhibitor-Related Myasthenia Gravis. [Journal Article]
    Continuum (Minneap Minn) 2019; 25(6):1785-1806Guidon AC
  • CONCLUSIONS: The diagnosis of LEMS, botulism, or immune-related MG can generally be made from the patient's history, supplemented with directed questions, a physical examination designed to demonstrate abnormalities, and laboratory and electrodiagnostic testing. Early diagnosis and carefully selected treatment not only improve outcomes of the neuromuscular disease but can affect the prognosis of underlying malignancy, when present.
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Amifampridine [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Amifampridine is an orally available potassium channel blocker that increases acetylcholine in synaptic clefts of peripheral nerve endings and is used to treat the Lambert-Eaton myasthenic syndrome. Amifampridine is associated with a low rate of transient serum enzyme elevations during therapy but has not been linked with instances of clinically apparent acute liver injury.
  • Amifampridine tablets for the treatment of Lambert-Eaton myasthenic syndrome. [Review]
    Expert Rev Clin Pharmacol 2019; 12(11):1013-1018Mantegazza R
  • Introduction: Lambert-Eaton myasthenic syndrome is an autoimmune disease of the neuromuscular junction characterized by a presynaptic defect of neuromuscular transmission resulting in muscle weakness and fatigability. Diagnostic features are specific neurophysiological alterations and autoantibody detection. The present review is focused on the use of Amifampridine Phosphate to treat LEMS patient…
  • Recent Advances and Therapeutic Options in Lambert-Eaton Myasthenic Syndrome. [Review]
    Cureus 2019; 11(8):e5450Anwar A, Saleem S, … Ashraf S
  • Lambert-Eaton Myasthenic Syndrome (LEMS) is an autoimmune-mediated neurological disorder that manifests as muscle fatigue, diminished tendon reflexes, with symptoms of cholinergic overactivity. It can be associated with certain neoplastic conditions, the most common being small cell lung carcinoma (SCLC). The basic pathophysiology involved is antibody-mediated targeting of voltage-gated calcium c…
  • Thymic small cell carcinoma associated with Lambert-Eaton myasthenic syndrome. [Journal Article]
    Ann Thorac Surg 2019Hashimoto S, Hayasaka K, … Shiono S
  • Thymic small cell cancer is a very rare type of thymic epithelial tumor. Lambert-Eaton myasthenic syndrome (LEMS) is a rare paraneoplastic syndrome associated with thymic epithelial tumors. We report an extremely rare case of LEMS associated with thymic small cell carcinoma. A 71-year-old man was referred to our institution for a mediastinal tumor and a 2-month history of ptosis, fatigue, and gai…
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