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(Leishmania)
26,309 results
  • Assessment of histological liver alterations in dogs naturally infected with Leishmania infantum. [Journal Article]
    Parasit Vectors 2019; 12(1):487Lima IS, Solcá MS, … de Freitas LAR
  • CONCLUSIONS: Our findings suggest that the presence of mononuclear inflammatory cells inside the sinusoids is more important than that of organized granulomas in terms of the containment of parasitism by the host. We suggest that the presence of granulomas indicates the failure of a first line of defense mechanism in the control of parasite infection, which could be related to the presence of inflammatory cells and Kupffer cell hypertrophy inside the sinusoids. We further demonstrated that dogs with active Leishmania spp. infection present a higher frequency of inflammatory changes in the liver. In addition to being correlated with the severity of clinical manifestation, these hepatic alterations were also associated with changes in hematological and biochemical parameters.
  • Improved annotation of Lutzomyia longipalpis genome using bioinformatics analysis. [Journal Article]
    PeerJ 2019; 7:e7862Yang Z, Wu Y
  • Lutzomyia longipalpis, a sand fly, is a vector-spreading pathogenic protozoan in the New World. MicroRNA (miRNA) is evolutionarily-conserved non-coding RNA, which plays critical roles in various biological processes. To date, the functions of most proteins in L. longipalpis are unknown, and few studies have addressed the roles of miRNAs in this species. In the present study, we re-annotated the p…
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