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26,644 results
  • Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani. [Letter]
    Molecules 2020; 25(3)Cabral LIL, Pomel S, … Cristiano MLS
  • A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm. The most active tetraoxane, compound LC140, exhibited an IC50 value of 2.52 ± 0.65 µm on L. donovani intramacrophage amastigotes, with a selectivity index of 1…
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