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319,779 results
  • A luciferase lysis assay reveals in vivo malignant cell sensitization by phosphoantigen prodrugs. [Journal Article]
    Biochem Pharmacol 2019; :113668Li J, Lentini NA, … Wiemer AJ
  • Human Vγ9Vδ2 T cells respond to small phosphorus-containing compounds, often called phosphoantigens, which are now known to be intracellular ligands of the immune receptor butyrophilin 3A1 (BTN3A1). In order to compare the efficiency of butyrophilin ligands, we developed a luciferase-based lysis assay that measures the direct cytolysis by Vγ9Vδ2 T cells of luciferase-expressing K562 leukemia cell…
  • Prognostic impact of RAS-pathway mutations in patients with myelofibrosis. [Journal Article]
    Leukemia 2019Santos FPS, Getta B, … Verstovsek S
  • RAS-pathway mutations are recurrent events in myeloid malignancies. However, there is limited data on the significance of RAS-pathway mutations in patients with myelofibrosis (MF). We analyzed next-generation sequencing data of 16 genes, including RAS-pathway genes, from 723 patients with primary and secondary MF across three international centers and evaluated their significance. N/KRAS variants…
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