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(Lieberkühn crypt)
107 results
  • Apical constriction is necessary for crypt formation in small intestinal organoids. [Journal Article]
    Dev Biol 2019; 450(2):76-81Hartl L, Huelsz-Prince G, … Tans SJ
  • Small intestinal organoids have become an important tool to study crypt homeostasis, cell fate dynamics and tissue biomechanics. Yet, the mechanisms that drive the budding of crypts from the smooth organoid epithelium remain incompletely understood. Locally enhanced proliferation has been suggested to induce tissue buckling and crypt initiation. Here we report that changes in cell morphology play…
  • Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine. [Journal Article]
    Stem Cell Reports 2019; 12(4):816-830Ziegler AN, Feng Q, … Levison SW
  • Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like growth factor II (IGF-II) is necessary for prenatal growth, its role in adult stem cell physiology is largely unknown. We show that loss of Igf2 in adult mice resulted in a ∼50% reduction …
  • Laxative effect of probiotic chocolate on loperamide-induced constipation in rats. [Journal Article]
    Food Res Int 2019; 116:1173-1182Eor JY, Tan PL, … Kim SH
  • The fecal morphology, defecation frequency, bowel function, intestinal motility, and fecal bacterial composition were evaluated to investigate the laxative effect of probiotic chocolate containing Streptococcus thermophilus MG510 and Lactobacillus plantarum LRCC5193 (LYC) on loperamide-induced constipated rats. Daily oral administration of LYC in constipated rats for two weeks was shown to signif…
  • Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia. [Journal Article]
    J Vis Exp 2018; (135)Stieler Stewart A, Freund JM, … Gonzalez LM
  • Intestinal ischemia remains a major cause of morbidity and mortality in human and veterinary patients. Many disease processes result in intestinal ischemia, when the blood supply and therefore oxygen is decreased to the intestine. This leads to intestinal barrier loss and damage to the underlying tissue. Intestinal stem cells reside at the base of the crypts of Lieberkühn and are responsible for …
  • Characterization the response of Korl:ICR mice to loperamide induced constipation. [Journal Article]
    Lab Anim Res 2016; 32(4):231-240Kim JE, Yun WB, … Hwang DY
  • Animal models of constipation induced with drugs and diet have been widely employed to investigate therapeutic effects and the action mechanism of drugs against this disease. ICR mice were selected to produce this disease model through oral administration of loperamide (Lop), even though SD rats are commonly utilized in studies of constipation. To compare the responses of ICR mice obtained from t…
  • Identification of the Paneth cells in chicken small intestine. [Journal Article]
    Poult Sci 2016; 95(7):1631-5Wang L, Li J, … Zhang CQ
  • The Paneth cells are highly specialized cells in the epithelium of the small intestine of many vertebrate species. These cells reside at the base of crypts of the Lieberkühn and contain abundant secretory granules. Previous studies suggesting the existence of Paneth cells in the chicken (Gallus gallus) remained controversial. Here we seek to identify the Paneth cells in the chicken small intestin…
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