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(Lobo disease)
1,175 results
  • Follicular helper T cells are major HIV-2 reservoirs and support productive infection. [Journal Article]
    J Infect Dis 2019Godinho-Santos A, Foxall RB, … Sousa AE
  • Follicular helper T cells (Tfh), CD4 lymphocytes critical for efficient antibody responses, have been shown to be key HIV-1 reservoirs. HIV-2 infection represents a unique naturally-occurring model for investigating Tfh role in HIV/AIDS, given its slow rate of CD4 decline, low to undetectable viremia and high neutralizing antibodies titers throughout the disease course. We investigated here, for …
  • Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer. [Journal Article]
    Elife 2019; 8Munkley J, Ling L, … Elliott DJ
  • Prostate is the most frequent cancer in men. Prostate cancer progression is driven by androgen steroid hormones, and delayed by androgen deprivation therapy (ADT). Androgens control transcription by stimulating androgen receptor (AR) activity, yet also control pre-mRNA splicing through less clear mechanisms. Here we find androgens regulate splicing through AR-mediated transcriptional control of t…
  • Diagnostic-therapeutic management of bile duct cancer. [Review]
    World J Clin Cases 2019; 7(14):1732-1752Huguet JM, Lobo M, … Sempere J
  • Biliary tract cancer, or cholangiocarcinoma, comprises a heterogeneous group of malignant tumors that can emerge at any part of the biliary tree. This group is the second most common type of primary liver cancer. Diagnosis is usually based on symptoms, which may be heterogeneous, and nonspecific biomarkers in serum and biopsy specimens, as well as on imaging techniques. Endoscopy-based diagnosis …
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