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(Lobo disease)
1,300 results
  • Anopheles sundaicus  complex and the presence of Anopheles epiroticus in Indonesia. [Journal Article]
    PLoS Negl Trop Dis. 2020 Jul 02; 14(7):e0008385.Syafruddin D, Lestari YE, … Lobo NF
  • Anopheles sundaicus s.l. is an important malaria vector primarily found in coastal landscapes of western and central Indonesia. The species complex has a wide geographical distribution in South and Southeast Asia and exhibits ecological and behavioural variability over its range. Studies on understanding the distribution of different members in the complex and their bionomics related to malaria t…
  • Intermediary metabolism: An intricate network at the crossroads of cell fate and function. [Review]
    Biochim Biophys Acta Mol Basis Dis. 2020 Jun 26 [Online ahead of print]Ferreira LMR, Li AM, … Urbano AM
  • Intermediary metabolism is traditionally viewed as the large, highly integrated network of reactions that provides cells with metabolic energy, reducing power and biosynthetic intermediates. The elucidation of its major pathways and molecular mechanisms of energy transduction occupied some of the brightest scientific minds for almost two centuries. When these goals were achieved, a sense that int…
  • Circulating Inflammatory miRNAs Associated with Parkinson's Disease Pathophysiology. [Journal Article]
    Biomolecules. 2020 Jun 23; 10(6)Oliveira SR, Dionísio PA, … Rodrigues CMP
  • Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, being largely characterized by motor features. MicroRNAs (miRNAs) are small non-coding RNAs, whose deregulation has been associated with neurodegeneration in PD. In this study, miRNAs targeting cell death and/or inflammation pathways were selected and their expression compared in the serum of PD patients and h…
  • Rheumatology practice amidst the COVID-19 pandemic: a pragmatic view. [Journal Article]
    RMD Open. 2020 Jun; 6(2)Romão VC, Cordeiro I, … Fonseca JE
  • The coronavirus disease 2019 (COVID-19) pandemic has come with many challenges for healthcare providers and patients alike. In addition to the direct burden it has placed on societies and health systems, it had a significant impact in the care of patients with chronic diseases, as healthcare resources were deployed to fight the crisis, and major travel and social restrictions were adopted. In the…
  • Challenges and Perspectives in the Management of Late-Stage Parkinson's Disease. [Journal Article]
    J Parkinsons Dis. 2020 Jun 15 [Online ahead of print]Fabbri M, Kauppila LA, … Rascol O
  • Parkinson's disease (PD) is a common neurodegenerative disorder, with a continuously increasing prevalence. With improved clinical and therapeutic management of PD, more patients reach later stages of the disease, meaning they may face new clinical problems that were not commonly approached. This gave way to the description of a new PD stage, late-stage PD (LSPD), which is clinically discernible …
  • Cisplatin Resistance in Testicular Germ Cell Tumors: Current Challenges from Various Perspectives. [Review]
    Cancers (Basel). 2020 Jun 17; 12(6)Lobo J, Jerónimo C, Henrique R
  • Testicular germ cell tumors share a marked sensitivity to cisplatin, contributing to their overall good prognosis. However, a subset of patients develop resistance to platinum-based treatments, by still-elusive mechanisms, experiencing poor quality of life due to multiple (often ineffective) interventions and, eventually, dying from disease. Currently, there is a lack of defined treatment opportu…
  • Methods and indicators for measuring patterns of human exposure to malaria vectors. [Journal Article]
    Malar J. 2020 Jun 16; 19(1):207.Monroe A, Moore S, … Killeen GF
  • CONCLUSIONS: If collected and used consistently, this information can contribute to an improved understanding of how malaria transmission persists in the context of current intervention tools, how exposure patterns may change as new vector control tools are introduced, and the potential impact and limitations of these tools. This article is intended to consolidate understanding around work on this topic to date and provide a consistent framework for building upon it. Additional work is needed to address remaining questions, including further development and validation of methods for entomological and human behavioural data collection and analysis.
  • Association of obesity with arterial stiffness: The Multi-Ethnic Study of Atherosclerosis (MESA). [Journal Article]
    Vasc Med. 2020 Jun 02 [Online ahead of print]Logan JG, Kang H, … Sohn MW
  • Arterial stiffness (AS) and obesity are recognized as important risk factors of cardiovascular disease (CVD). The purpose of this study was to investigate the relationship between AS and obesity. AS was defined as high augmentation index (AIx) and low C1 and C2 in participants enrolled in the Multi-Ethnic Study of Atherosclerosis at baseline. We compared AIx, C1, and C2 by body mass index (BMI) (…
  • From natural disaster to pandemic: A health-system pharmacy rises to the challenge. [Journal Article]
    Am J Health Syst Pharm. 2020 May 16 [Online ahead of print]Zuckerman AD, Patel PC, … Hayman J
  • CONCLUSIONS: In early March 2020, a tornado destroyed the health system's warehouse for storage of most clinical supplies, including personal protective equipment and fluids. The pharmacy purchasing team collaborated with suppliers and manufacturers to recover losses and establish alternative storage areas. Days later, the pharmacy department was forced to address the impending COVID-19 pandemic. Key elements of the COVID-19 response included reducing the potential for patient and staff virus exposure; overcoming challenges in sourcing of staff, personal protective equipment, and medications; and changing care delivery practices to maintain high-quality patient care while maximizing social distancing. The pharmacy department also created distance learning opportunities for 70 pharmacy students on rotations. After an initial plan, ongoing needs include adjustment in patient care activities if significant staff losses occur, when and how to resume clinical activities, and how to best utilize the resources accumulated. Elements of practice changes implemented to reduce COVID-19 threats to patients and pharmacy personnel have proven beneficial and will be further evaluated for potential continuation.The pharmacy department's efforts to respond to a natural disaster and unprecedented pandemic have proven successful to this point and have illuminated several lessons, including the necessity of cohesive department communication, staff flexibility, prioritization of teamwork, and external collaboration.
  • Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation. [Journal Article]
    J Immunol. 2020 May 15 [Online ahead of print]Stark AK, Davenport ECM, … Okkenhaug K
  • Class I PI3K enzymes are critical for the maintenance of effective immunity. In T cells, PI3Kα and PI3Kδ are activated by the TCR and costimulatory receptors, whereas PI3Kγ is activated by G protein-coupled chemokine receptors. PI3Kδ is a key regulator of regulatory T (Treg) cell function. PI3K isoform-selective inhibitors are in development for the treatment of diseases associated with immune dy…
  • Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects. [Journal Article]
    Cell Metab. 2020 Jun 02; 31(6):1120-1135.e7.Mahú I, Barateiro A, … Domingos AI
  • Anti-obesity drugs in the amphetamine (AMPH) class act in the brain to reduce appetite and increase locomotion. They are also characterized by adverse cardiovascular effects with origin that, despite absence of any in vivo evidence, is attributed to a direct sympathomimetic action in the heart. Here, we show that the cardiac side effects of AMPH originate from the brain and can be circumvented by…
  • Preliminary Report of Pyrethroid Resistance in Anopheles vagus, an Important Malaria Vector in Bangladesh. [Journal Article]
    Am J Trop Med Hyg. 2020 May 11 [Online ahead of print]Alam MS, Al-Amin HM, … Lobo NF
  • According to the WHO, unmanaged insecticide resistance may lead to increases in malaria-related mortality and morbidity. Bangladesh, having made significant progress in malaria control efforts, has recently seen an upswing in malaria cases-58% of which occurred in Bandarban district. Toward identifying entomological drivers of increased malaria, an entomological survey including Anopheles suscept…
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