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(Loboa loboi)
2,003 results
  • Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis. [Journal Article]
    PLoS Pathog 2019; 15(8):e1007990Ketelut-Carneiro N, Souza COS, … Silva JS
  • The granulomatous lesion resulting from infection with the fungus Paracoccidioides brasiliensis is characterized by a compact aggregate of mature cells, surrounded by a fibroblast- and collagen-rich content. Granuloma formation requires signaling elicited by inflammatory molecules such as members of the interleukin-1 family. Two members of this family have been thoroughly studied, namely IL-1α an…
  • A Case of Disseminated Paracoccidioidomycosis Associated with Cutaneous Lobomycosis. [Journal Article]
    J Eur Acad Dermatol Venereol 2019Heleine M, Blaizot R, … Couppie P
  • Paracoccidioides braziliensis and Lacazia loboi are fungal agents responsible for invasive infections in endemic areas of South America 1,2 . These pathogens share very close phylogenetic characteristics but present different clinical manifestations and ways of infection. We report the first case of paracoccidioidomycosis associated with lobomycosis. A 48-year-old male farmer from Brazil consulte…
  • New inhibitors of chorismate synthase present antifungal activity against Paracoccidioides brasiliensis. [Journal Article]
    Future Microbiol 2019; 14:969-980Bueno PS, Rodrigues-Vendramini FA, … Seixas FA
  • Aim: A structural model of chorismate synthase (CS) from the pathogenic fungus Candida albicans was used for virtual screening simulations. Methods: Docking, molecular dynamics, cell growth inhibition and protein binding assays were used for search and validation. Results: Two molecules termed CS8 and CaCS02 were identified. Further studies of the minimal inhibitory concentration demonstrated …
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