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(Lopinavir ritonavir AND ("Novel Coronavirus" OR COVID-19 OR SARS-CoV-2 OR 2019-nCoV))
853 results
  • Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19. [Journal Article]
    Cureus. 2021 Mar 04; 13(3):e13687.Salvador P, Oliveira P, … Malheiro L
  • Introduction Since the declaration of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in March 2020, Portugal was considered a role model with regards to the first COVID-19 wave. However, a third wave started in 2021 started, turning the country into the worst in the world regarding new infections and death rate per capita in the last weeks of January 2021. No significan…
  • Drugs intervention study in COVID-19 management. [Review]
    Drug Metab Pers Ther. 2021 Apr 05 [Online ahead of print]Taher M, Tik N, Susanti D
  • By 9 February 2021, the Coronavirus has killed 2,336,650 people worldwide and it has been predicted that this number continues to increase in year 2021. The study aimed to identify therapeutic approaches and drugs that can potentially be used as interventions in Coronavirus 2019 (COVID-19) management. A systematic scoping review was conducted. Articles reporting clinical evidence of therapeutic m…
  • Predictive factors of six-week mortality in critically ill patients with SARS-CoV-2: A multicenter prospective study. [Journal Article]
    Med Intensiva. 2021 Mar 08 [Online ahead of print]Estella Á, Garcia Garmendia JL, … Work Group of Infectious Disease (GTEI) de la Sociedad Andaluza de Medicina Intensiva y Unidades coronarias SAMIUC
  • CONCLUSIONS: Age, APACHE II, SOFA>value of 6 points, along with vasopressor requirements or renal replacement therapy have been identified as predictor factors of mortality at six weeks. Administration of corticosteroids showed no benefits in mortality, as did treatment with tocilizumab. Lopinavir/ritonavir administration is identified as a protective factor.
  • Pharmacogenetics Approach for the Improvement of COVID-19 Treatment. [Review]
    Viruses. 2021 03 05; 13(3)Fricke-Galindo I, Falfán-Valencia R
  • The treatment of coronavirus disease 2019 (COVID-19) has been a challenge. The efficacy of several drugs has been evaluated and variability in drug response has been observed. Pharmacogenetics could explain this variation and improve patients' outcomes with this complex disease; nevertheless, several disease-related issues must be carefully reviewed in the pharmacogenetic study of COVID-19 treatm…
  • Discovery of Potent Covid-19 Main Protease Inhibitors using Integrated Drug Repurposing Strategy. [Journal Article]
    Biotechnol Appl Biochem. 2021 Apr 01 [Online ahead of print]Kumar TM, Rohini K, … Ramanathan K
  • The emergence and rapid spreading of novel SARS-CoV-2 across the globe represent an imminent threat to public health. Novel anti-viral therapies are urgently needed to overcome this pandemic. Given the significant role of the main protease of Covid-19 for virus replication, we performed a drug repurposing study using recently deposited main protease structure, 6LU7. For instance, pharmacophore- a…
  • Evaluation of the Current Therapeutic Approaches for COVID-19: A Systematic Review and a Meta-analysis. [Review]
    Front Pharmacol. 2021; 12:607408.Abdelrahman Z, Liu Q, … Wang X
  • CONCLUSIONS: Antivirals are safe and effective in COVID-19 treatment. Remdesivir cannot significantly reduce COVID-19 mortality and hospitalization length, while it is associated with a lower incidence of severe adverse events. Corticosteroids could increase COVID-19 severity, but it could be beneficial when combined with antivirals. Our data are potentially valuable for the clinical treatment and management of COVID-19 patients.
  • COVID 19 infection in young patient with pectus excavatum [Journal Article]
    Rev Fac Cien Med Univ Nac Cordoba. 2021 03 25; 78(1):52-56.Puglla Sánchez LR, Sinche Cueva CA, Quilismal Guanochanga NC
  • CONCLUSIONS: The case reflects what is known to date about the risk of severe complications that SARS-CoV-2 infection can present in patients with comorbidities or pathologies that alter lung function such as the pectus excavatum. Therefore it would be important to generate specific management protocols for the clinical improvement of these patients with congenital anatomical alterations.
  • Multicenter Analysis of Clinical Features and Prognosis of COVID-19 Patients with Hepatic Impairment. [Journal Article]
    Gut Liver. 2021 Apr 02 [Online ahead of print]Song JE, Kang MK, … Daegu-Gyeongbuk Liver Study Group (DGLSG)
  • CONCLUSIONS: Abnormal aminotransferase levels are common in COVID-19 patients and are associated with poor clinical outcomes. Multivariate analysis of patients with normal aminotransferase levels on admission showed that the use of lopinavir/ritonavir and antibiotics was associated with abnormal aminotransferase levels; thus, careful monitoring is needed.
  • Judicious use of low-dosage corticosteroids for non-severe COVID-19: A case report. [Case Reports]
    Open Med (Wars). 2021; 16(1):440-445.Zhang J, Tian Z, … Cui W
  • Inflammation-mediated lung injury in severe cases of infection with SARS-CoV-2, the aetiological agent of Coronavirus disease 2019 (COVID-19), can lead to respiratory failure and death, and therapies that block or ameliorate lung injury-associated inflammatory "cytokine storms" and progression to acute respiratory distress syndrome (ARDS) are urgently needed. Therapeutic use of corticosteroids fo…
  • Modeling of SARS-CoV-2 Treatment Effects for Informed Drug Repurposing. [Review]
    Front Pharmacol. 2021; 12:625678.Kern C, Schöning V, … Hammann F
  • Several repurposed drugs are currently under investigation in the fight against coronavirus disease 2019 (COVID-19). Candidates are often selected solely by their effective concentrations in vitro, an approach that has largely not lived up to expectations in COVID-19. Cell lines used in in vitro experiments are not necessarily representative of lung tissue. Yet, even if the proposed mode of actio…
  • Clinical effectiveness of drugs in hospitalized patients with COVID-19: a systematic review and meta-analysis. [Meta-Analysis]
    Ther Adv Respir Dis. 2021 Jan-Dec; 15:17534666211007214.Abeldaño Zuñiga RA, Coca SM, … González-Villoria RAM
  • The aim was to assess the clinical effectiveness of drugs used in hospitalized patients with COVID-19 infection. We conducted a systematic review of randomized clinical trials assessing treatment with remdesivir, chloroquine, hydroxychloroquine, lopinavir, ritonavir, dexamethasone, and convalescent plasma, for hospitalized patients with a diagnosis of SARS-CoV-2 infection. The outcomes were morta…
  • An Update on Antiviral Therapy Against SARS-CoV-2: How Far Have We Come? [Review]
    Front Pharmacol. 2021; 12:632677.Indari O, Jakhmola S, … Jha HC
  • COVID-19 pandemic has spread worldwide at an exponential rate affecting millions of people instantaneously. Currently, various drugs are under investigation to treat an enormously increasing number of COVID-19 patients. This dreadful situation clearly demands an efficient strategy to quickly identify drugs for the successful treatment of COVID-19. Hence, drug repurposing is an effective approach …
  • Analyzing knowledge entities about COVID-19 using entitymetrics. [Journal Article]
    Scientometrics. 2021 Mar 12 [Online ahead of print]Yu Q, Wang Q, … Bu Y
  • COVID-19 cases have surpassed the 109 + million markers, with deaths tallying up to 2.4 million. Tens of thousands of papers regarding COVID-19 have been published along with countless bibliometric analyses done on COVID-19 literature. Despite this, none of the analyses have focused on domain entities occurring in scientific publications. However, analysis of these bio-entities and the relations …
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