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860 results
  • Low-cost anti-mycobacterial drug discovery using engineered E. coli. [Journal Article]
    Nat Commun. 2022 Jul 07; 13(1):3905.Bongaerts N, Edoo Z, … Wintermute EH
  • Whole-cell screening for Mycobacterium tuberculosis (Mtb) inhibitors is complicated by the pathogen's slow growth and biocontainment requirements. Here we present a synthetic biology framework for assaying Mtb drug targets in engineered E. coli. We construct Target Essential Surrogate E. coli (TESEC) in which an essential metabolic enzyme is deleted and replaced with an Mtb-derived functional ana…
  • StatPearls: Benazepril [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)DahalSujata S.SSCalifornia Northstate UniversityGuptaMohitMCleveland Clinic FoundationBOOK
  • Benazepril is a drug used in the management of hypertension. It is in the ACE inhibitor class of medications. This activity outlines the indications, action, and contraindications for benazepril as a valuable agent in managing hypertension (and other disorders when applicable). This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses…
  • Molecular modelling and in vitro studies of Daruharidra as a potent alpha-amylase inhibitor. [Journal Article]
    J Biomol Struct Dyn. 2022 Apr 12 [Online ahead of print]Bhatnagar A, Saini R, … Mishra A
  • The present study aims at exploring the potential of the Daruharidra plant (stem and bark) for inhibition of alpha-amylase. Aqueous and ethanolic extraction yielded the highest total phenolic content (TPC) of 101.4 and 111.8 mcg of gallic acid equivalent. Methanol and ethanol extract had Total flavonoid content (TFC) of 319.6 and 288.3 mcg of quercetin equivalent, respectively. In contrast, petro…
  • Treatments for Chronic Kidney Disease: A Systematic Literature Review of Randomized Controlled Trials. [Review]
    Adv Ther. 2022 01; 39(1):193-220.Garcia Sanchez JJ, Thompson J, … Abrams KR
  • Delaying disease progression and reducing the risk of mortality are key goals in the treatment of chronic kidney disease (CKD). New drug classes to augment renin-angiotensin-aldosterone system (RAAS) inhibitors as the standard of care have scarcely met their primary endpoints until recently. This systematic literature review explored treatments evaluated in patients with CKD since 1990 to underst…
  • Molecular modeling of the interaction of ligands with ACE2-SARS-CoV-2 spike protein complex. [Journal Article]
    In Silico Pharmacol. 2021; 9(1):55.Isaac-Lam MF
  • COVID-19 is a new communicable disease with a widespread outbreak that affects all populations worldwide triggering a rush of scientific interest in coronavirus research globally. In silico molecular docking experiment was utilized to determine interactions of available compounds with SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2) complex. Chimera and AutoDock Vina were used for protein-li…
  • Repurposing the inhibitors of COVID-19 key proteins through molecular docking approach. [Journal Article]
    Process Biochem. 2021 Nov; 110:216-222.Alghamdi HA, Attique SA, … Nawaz MZ
  • The severe acute respiratory syndrome coronavirus 2, famous as COVID-19, has recently emerged as a novel virus and imposed an unrecoverable loss to global health and the economy. At present, no effective drug against COVID-19 is available and currently available viral drugs targeting the viral key proteins of related RNA viruses have been found ineffective against COVID-19. This study evaluated t…
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