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13,688 results
  • Children and adolescents' experiences of primary lymphoedema: semistructured interview study. [Journal Article]
  • ADArch Dis Child 2018 Feb 17
  • Hanson CS, Newsom J, … Tong A
  • CONCLUSIONS: Children and adolescents learn to adjust to the daily demands of lymphoedema management by individualising and accepting their treatment, but many continue to struggle with their self-esteem and lifestyle restrictions. Strategies are needed to empower young patients to advocate for themselves during their transition to adult care. Treatment plans that minimise social restrictions, address emotional consequences and incorporate patients' preferences could improve adherence, satisfaction and outcomes.
  • Primary lymphedema and other lymphatic anomalies are associated with 22q11.2 deletion syndrome. [Journal Article]
  • EJEur J Med Genet 2018 Feb 12
  • Unolt M, Barry J, … McDonald-McGinn DM
  • CONCLUSIONS: We report the novel association of primary lymphedema with 22q11.2 deletion syndrome. Importantly, animal models demonstrated Tbx1 playing a critical role in lymphangiogenesis by reducing Vegfr3 expression in lymphatic endothelial cells. Moreover, the VEGFR3 pathway is essential for lymphangiogenesis with mutations identified in hereditary primary lymphedema. Accordingly, our findings provide a new insight into understanding cellular mechanisms of lymphangiogenesis disorders.
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