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5,873 results
  • Genomewide copy number alteration screening of circulating plasma DNA: potential for the detection of incipient tumors. [Journal Article]
  • AOAnn Oncol 2018 Oct 29
  • Lenaerts L, Vandenberghe P, … Vermeesch JR
  • CONCLUSIONS: Genomewide profiling of cfDNA in apparently healthy individuals enables the detection of incipient hematological malignancies as well as clonal mosaicism with unknown clinical significance. CNA screening of cellular DNA of peripheral blood in elderly has established that clonal mosaicism for these chromosomal anomalies predicts a 5 to 10-fold enhanced risk of a subsequent cancer. We demonstrate that cfDNA screening detects CNAs, which are not only derived from peripheral blood, but even more from other tissues. Since the clinical relevance of clonal mosaics in other tissues remains unknown, long-term follow-up is warranted. Taken together, this study demonstrates that genomewide cfDNA analysis has potential as an unbiased screening approach for hematological malignancies and premalignant conditions.
  • Study of Central Nervous System Tuberculosis. [Journal Article]
  • JAJ Assoc Physicians India 2018; 66(1):41-44
  • Aher A, Paithankar M, Bhurke B
  • CONCLUSIONS: Diagnosis of CNS TB should be based on clinical features and 3 or more supportive criteria rather than CSF positivity on staining or culture. Rapid and early diagnosis by positive CSF PCR and CT/MRI findings should replace CSF AFB staining and culture in further for the diagnosis of CNS TB.
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