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(Lymphoma)
259,989 results
  • Ibrutinib in CLL/SLL: From bench to bedside (Review). [Journal Article]
    Oncol Rep 2019Zi F, Yu L, … Cheng J
  • B-cell receptor (BCR) signaling is important for the development and maturation of normal B-cells and plays a key role in B-cell malignancies. Bruton's tyrosine kinase (BTK), a crucial terminal kinase enzyme in BCR signaling, has emerged as an attractive target and has been successfully applied in the treatment of hematological malignancies. Ibrutinib, a BTK inhibitor, has demonstrated marked eff…
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