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Unbound Medicine.
(Lyon hypothesis)
5,641 results
  • Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? [Letter]
    J Infect. 2020 Jun 30 [Online ahead of print]Batisse D, Benech N, … Wyplosz B
  • For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the clinical history, we discuss either re-infection or reactivation hypothesis. Larger studies includi…
  • Signal changes in enhanced T1-weighted images related to gadolinium retention: a three-time-point imaging study. [Journal Article]
    J Neuroradiol. 2020 Jun 29 [Online ahead of print]Lersy F, Diepenbroek AL, … Kremer S
  • CONCLUSIONS: After exposure to gadobenate dimeglumine, the signal intensity (SI) tended to increase after the fifth injection owing to gadolinium accumulation, however, a SI increase was not found after the tenth administration supporting the hypothesis of a slow elimination of the previously retained gadolinium (wash-out effect) from the brain or of a change in form (by dechelation), causing the signal to fade. No increasing SI was found in the DN and GP after exclusive exposure to gadoterate meglumine, thus confirming its stability. We found, instead, a trend for a significative gadolinium elimination over time.
  • Competition for safe real estate, not food, drives density-dependent juvenile survival in a large herbivore. [Journal Article]
    Ecol Evol. 2020 Jun; 10(12):5464-5475.Hurley MA, Hebblewhite M, Gaillard JM
  • Density-dependent competition for food reduces vital rates, with juvenile survival often the first to decline. A clear prediction of food-based, density-dependent competition for large herbivores is decreasing juvenile survival with increasing density. However, competition for enemy-free space could also be a significant mechanism for density dependence in territorial species. How juvenile surviv…
  • Tool-number interaction during a prospective memory task. [Journal Article]
    Cogn Process. 2020 Jun 29 [Online ahead of print]Badets A, Duville M, Osiurak F
  • Theoretical views suggest that tool use and numerical magnitude processing can interact during prospective actions. For example, if a person intends to make a meal for several persons the next week, she/he will have to keep in mind during the homework-week large dish and large food portions for this event. Here, the magnitude 'large' can influence the future choice for large dishes and other rela…
  • SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell properties during fetal epaxial myogenesis. [Journal Article]
    Development. 2020 Jun 26 [Online ahead of print]Wurmser M, Chaverot N, … Maire P
  • Pax7 expression marks stem cells in developing skeletal muscles and adult satellite cells during homeostasis and muscle regeneration. The genetic determinants that control the entrance into the myogenic program and the appearance of PAX7+ cells during embryogenesis are poorly understood. SIX homeoproteins are encoded by the Sine oculis homeobox related Six1-Six6 genes in vertebrates. Six1, Six2, …
  • X-Chromosome Inactivation during Preimplantation Development and in Pluripotent Stem Cells. [Journal Article]
    Cytogenet Genome Res. 2020 Jun 24 [Online ahead of print]Rebuzzini P, Zuccotti M, Garagna S
  • X dosage compensation between XX female and XY male mammalian cells is achieved by a process known as X-chromosome inactivation (XCI). XCI initiates early during preimplantation development in female cells, and it is subsequently stably maintained in somatic cells. However, XCI is a reversible process that occurs in vivo in the inner cell mass of the blastocyst, in primordial germ cells or in spe…
  • Complexity of interruptions: Evidence supporting a non-interruption-based theory. [Journal Article]
    Scand J Psychol. 2020 Jun 22 [Online ahead of print]Brazzolotto P, Michael GA
  • Interruptions are known to be pervasive and harmful for concentration. It is also known that many factors can influence their effect, such as the complexity of the interrupting task. Less, however, is known about the processes underlying the resumption of the primary task, especially if the interrupting task is complex. Many hypotheses have been proposed but, as yet, it has not been possible to d…
  • Determining a critical threshold for G6PD activity below which red blood cell response to oxidative stress is poor. [Journal Article]
    Malar J. 2020 Jun 17; 19(1):208.Swastika M, Harahap AR, … Satyagraha AW
  • CONCLUSIONS: The GSH analysis has pointed to the 60% G6PD activity cut-off and this data is supportive of the old World Health Organization threshold for intermediate upper limit of 60% G6PD activity. However, there are significant limitations in using MDA assay with CuCl RBC model because the RBC was already stressed due to the copper treatment and thus present a different result when compared to the ex vivo model.
  • Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment. [Journal Article]
    Dev Cell. 2020 Jun 10 [Online ahead of print]Colognori D, Sunwoo H, … Lee JT
  • X chromosome inactivation (XCI) is a global silencing mechanism by which XX and XY mammals equalize X-linked gene dosages. XCI begins with an establishment phase during which Xist RNA spreads and induces de novo heterochromatinization across a female X chromosome and is followed by a maintenance phase when multiple epigenetic pathways lock down the inactive X (Xi) state. Involvement of Polycomb r…
  • Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients. [Journal Article]
    Front Oncol. 2020; 10:822.Foy JP, Bertolus C, … Saintigny P
  • In some western countries, an increasing incidence of oral squamous cell carcinoma (OSCC) has been observed in non-smoker non-drinker patients (NSND), mostly in women with HPV-negative OSCC. In the context of the unknown etiology and mechanisms of tumorigenesis of OSCC in NSND, we discuss data supporting the hypothesis of a viral origin not related to HPV. OSCC from NSND are characterized by an a…
  • Maternal H3K27me3-dependent autosomal and X chromosome imprinting. [Review]
    Nat Rev Genet. 2020 Jun 08 [Online ahead of print]Chen Z, Zhang Y
  • Genomic imprinting and X-chromosome inactivation (XCI) are classic epigenetic phenomena that involve transcriptional silencing of one parental allele. Germline-derived differential DNA methylation is the best-studied epigenetic mark that initiates imprinting, but evidence indicates that other mechanisms exist. Recent studies have revealed that maternal trimethylation of H3 on lysine 27 (H3K27me3)…
  • StatPearls: Genetics, X-Linked Inheritance [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Basta Marina M St. George's University, School of Medicine Pandya Ashish M. AM Saurashtra University Rajkot India. PDU Goverment Medical College & Hospital Rajkot Gujarat India BOOK
  • The X chromosome contains 867 identified genes; most of these genes are responsible for the development of tissues like bone, neural, blood, hepatic, renal, retina, ears, ear, cardiac,  skin, and teeth. There are at least 533 disorders due to the involvement of the genes on the X chromosome.[1] A 'trait' or 'disorder' determined by a gene on the X  chromosome demonstrates X-linked inheritance.  I…
  • Long noncoding RNAs and their link to cancer. [Review]
    Noncoding RNA Res. 2020 Jun; 5(2):77-82.Grixti JM, Ayers D
  • The central dogma of molecular biology, developed from the study of simple organisms such as Escherichia coli, has up until recently been that RNA functions mainly as an information intermediate between a DNA sequence (gene), localized in the cell nucleus, serving as a template for the transcription of messenger RNAs, which in turn translocate into the cytoplasm and act as blueprints for the tran…
  • Variation in the ontogenetic allometry of horn length in bovids along a body mass continuum. [Journal Article]
    Ecol Evol. 2020 May; 10(9):4104-4114.Tidière M, Gaillard JM, … Pélabon C
  • Allometric relationships describe the proportional covariation between morphological, physiological, or life-history traits and the size of the organisms. Evolutionary allometries estimated among species are expected to result from species differences in ontogenetic allometry, but it remains uncertain whether ontogenetic allometric parameters and particularly the ontogenetic slope can evolve. In …
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