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65 results
  • Reduced susceptibility and resistance to bedaquiline in clinical M. tuberculosis isolates. [Journal Article]
    J Infect. 2020 May; 80(5):527-535.Peretokina IV, Krylova LY, … Zimenkov DV
  • CONCLUSIONS: Bedaquiline treatment leads to an elevated bedaquiline MIC and the acquisition of mmpR and atpE gene mutations in tuberculosis strains. The standardisation of bedaquiline phenotypic susceptibility testing is urgently needed based on observed discrepancies between our study and previous studies and differences in solid and liquid media MIC determinations.
  • Impact of adherence and weight loss on glycemic control in patients with type 2 diabetes: cohort analyses of integrated medical record, pharmacy claims, and patient-reported data. [Journal Article]
    J Manag Care Spec Pharm. 2014 Jul; 20(7):691-700.McAdam-Marx C, Bellows BK, … Brixner DI
  • CONCLUSIONS: This study has provided additional evidence in a managed, integrated setting that in patients treated for T2DM, weight loss is associated with good glycemic control. Adherence is associated with weight loss according to self-report, but not claims-based adherence measures. Adherence is also associated with glycemic control as measured by the 2 different methods. This study adds to the body of literature highlighting the importance of adherence as well as weight loss in achieving good glycemic control. The fact that the association of weight loss and adherence on glycemic control outcomes was significant regardless of medication adherence method is important in payer-provider collaborations, where access to data sources to evaluate adherence may vary. This study also supports continued investment in weight loss and adherence programs in the management of patients with T2DM.
  • The role of xanthine oxidase in thiopurine metabolism: a case report. [Case Reports]
    Ther Drug Monit. 2007 Dec; 29(6):845-8.Wong DR, Derijks LJ, … Hooymans PM
  • Azathioprine (AZA) is widely used in the treatment of autoimmune inflammatory diseases. AZA is normally rapidly and almost completely converted to 6-mercaptopurine (6-MP) in the liver, which is further metabolized into a variety of pharmacologic active thiopurine metabolites. 6-MP is catabolized by xanthine oxidase (XO) to the inactive metabolite 6-thiouric acid. The authors report the case of a …
  • Hepatotoxicity of 6-mercaptopurine (6-MP) and Azathioprine (AZA) in adult IBD patients. [Journal Article]
    Am J Gastroenterol. 2007 Nov; 102(11):2488-94.Shaye OA, Yadegari M, … Tran TT
  • CONCLUSIONS: 6-MP/AZA-induced hepatotoxicity is uncommon in the adult population. Although hepatotoxicity is associated with higher mean 6-MMPR levels, the sensitivity and specificity of 6-MMPR for drug-induced hepatotoxicity was poor. Monitoring liver tests in patients on 6-MP/AZA is suggested, and dose reduction or cessation of 6-MP/AZA, even with high 6-MMPR levels, should be reserved for patients with elevated aminotransferases.
  • Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase. [Journal Article]
    Acta Crystallogr D Biol Crystallogr. 2007 Feb; 63(Pt 2):126-34.Zhang Y, El Kouni MH, Ealick SE
  • Adenosine kinase (AK) is a key enzyme in purine metabolism in the ubiquitous intracellular parasite Toxoplasma gondii and is a potential chemotherapeutic target for the treatment of T. gondii infections. To better understand the structure-activity relationship of 6-substituted purine ribosides, the structures of the T. gondii AK-N6,N6-dimethyladenosine (DMA) complex, the AK-DMA-AMP-PCP complex, t…
  • Induction of meiotic maturation in mouse oocytes by adenosine analogs. [Journal Article]
    Mol Reprod Dev. 2006 Sep; 73(9):1159-68.Downs SM, Chen J
  • In this study we have examined the meiosis-inducing influence of adenosine analogs in mouse oocytes. When a varied group of nucleosides and nucleotides were tested on overnight cultures of hypoxanthine-arrested, cumulus cell-enclosed oocytes (CEO), halogenated adenosine nucleosides, but not native adenosine, exhibited a significant meiosis-inducing capability. When tested under a variety of condi…
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