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24,066 results
  • Current trends in tendinopathy management. [Review]
    Best Pract Res Clin Rheumatol 2019; 33(1):122-140Cardoso TB, Pizzari T, … Cook JL
  • Tendinopathy (pain and dysfunction in a tendon) is a prevalent clinical musculoskeletal presentation across the age spectrum, mostly in active and sporting people. Excess load above the tendon's usual capacity is the primary cause of clinical presentation. The propensity towards chronicity and the extended times for recovery and optimal function and the challenge of managing tendinopathy in a spo…
  • CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity. [Journal Article]
    Elife 2019; 8Park MH, Kim AK, … Lee YM
  • CCN1 (CYR61) stimulates active angiogenesis in various tumours, although the mechanism is largely unknown. Here, we report that CCN1 is a key regulator of endothelial tip cell activity in angiogenesis. Microvessel networks and directional vascular cell migration patterns were deformed in ccn1-knockdown zebrafish embryos. CCN1 activated VEGFR2 and downstream MAPK/PI3K signalling pathways, YAP/TAZ,…
  • Effects of misoprostol treatment on doxorubicin induced renal injury in rats. [Journal Article]
    Biotech Histochem 2019; :1-8Bilgic S, Armagan I
  • We investigated the potential nephroprotective effects of misoprostol (MP) on doxorubicin (DOX) induced renal injury using histologic and biochemical assessment of rat kidneys. We used 21 male rats divided into three groups: group 1, control; group 2, DOX; group 3, DOX + MP. The control group was given 0.5 ml 0.9% NaCl and 1 ml 0.9% NaCl orally for 6 days. DOX was administered as a single dose of…
  • Micronutrients decline under long-term tillage and nitrogen fertilization. [Journal Article]
    Sci Rep 2019; 9(1):12020Shiwakoti S, Zheljazkov VD, … Xing B
  • Tillage and nitrogen (N) fertilization can be expected to alter micronutrient dynamics in the soil and in plants over time. However, quantitative information regarding the effects of tillage and N application rates on micronutrient dynamics is limited. The objectives of this study were (a) to determine the long-term effect of different tillage methods as well as variation in N application rates o…
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