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11,830 results
  • A review of intralesional wart therapy. [Journal Article]
    Dermatol Online J. 2020 Mar 15; 26(3)Muse ME, Stiff KM, … Feldman SR
  • CONCLUSIONS: Each study varied in their agents, treatment interval, and treatment dose, making comparisons difficult.Intralesional wart injections are safe, affordable, and efficacious treatments for warts. Physicians should consider intralesional injections for patients with refractory warts, multiple warts, or warts in sensitive areas.
  • Exogenous intoxication by non-prescribed use of vitamin D, a case report. [Journal Article]
    BMC Geriatr. 2020 Jun 24; 20(1) Paula ALT, Gonzaga WPF, … Markus J
  • CONCLUSIONS: Our report summarizes the possible consequences of using a vitamin compound without supervision of a competent professional, as these substances are mistakenly considered non-toxic. To add, little information is available about the supplements' metabolism and their biological effects. Therefore, It is difficult to diagnose intoxication. This case report shows that even the self-administration of a product designed to bring health benefits can become a risky behavior. These vitamin and mineral supplements are supposed to bring patient empowerment and reduce government spending in health-care, but indeed represent a significant public health concern due to possible overdose and drug interactions.
  • Complementary and Alternative Medicine in Radiotherapy: A Comprehensive Review. [Journal Article]
    Top Magn Reson Imaging. 2020 Jun; 29(3):149-156.Borm KJ, Schiller K, … Combs SE
  • Complementary and alternative medicine (CAM) approaches are widely used by patients throughout a broad range of medical fields and diseases, and often self-administered by patients without the involvement of physicians or other members of the health care team. CAM use is well documented in cancer and chronic illnesses, and emerging data in radiation oncology show CAM usage of 26% to 97% in radiat…
  • Effects of IC50 dose of retinol on metabolomics of RAW264.7 cells. [Journal Article]
    J Food Biochem. 2020 Jun 15 [Online ahead of print]Wang Y, Song X, Geng Y
  • Vitamin A is one of the most multifunctional vitamins in normal human physiology and is involved in several basic physiological processes from embryonic development to adulthood, such as embryogenesis, vision, immunity, cell differentiation, and proliferation. In this study, we conducted 1 H- NMR to evaluate the metabolomic changes in RAW264.7 cells after treatment with retinol at an IC50 dose to…
  • Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. [Review]
    Nutrients. 2020 Jun 10; 12(6)Reider CA, Chung RY, … Hazels Mitmesser S
  • A well-functioning immune system is essential for human health and well-being. Micronutrients such as vitamins A, C, D, E, and zinc have several functions throughout the immune system, yet inadequate nutrient intakes are pervasive in the US population. A large body of research shows that nutrient inadequacies can impair immune function and weaken the immune response. Here, we present a new analys…
  • Vitamin C deficiency mimicking inflammatory bone disease of the hand. [Journal Article]
    Pediatr Rheumatol Online J. 2020 Jun 09; 18(1):45.Liebling EJ, Sze RW, Behrens EM
  • CONCLUSIONS: This represents the first description of scurvy manifesting with bone and soft tissue changes limited to the hands. There must be a high index of suspicion for scurvy in children with restricted dietary intake or malabsorption who have bone pain, irrespective of location of the lesions.
  • Vitamin K supplementation for cystic fibrosis. [Review]
    Cochrane Database Syst Rev. 2020 Jun 04; 6:CD008482.Jagannath VA, Thaker V, … Price AI
  • CONCLUSIONS: There is very low-quality evidence of any effect of vitamin K in people with cystic fibrosis. While there is no evidence of harm, until better evidence is available the ongoing recommendations by national CF guidelines should be followed.
  • Strategies to Combat Heat Stress in Broiler Chickens: Unveiling the Roles of Selenium, Vitamin E and Vitamin C. [Review]
    Vet Sci. 2020 Jun 01; 7(2)Shakeri M, Oskoueian E, … Shakeri M
  • Heat stress compromises efficient poultry production by impairing growth performance and increasing mortality. Mechanisms to dissipate excess heat divert energy from efficient production. This includes increased energy expenditure for respiration, oxidative stress and micronutrient absorption. The fortification of diets with particular feed additives has been known as one of the most important ap…
  • Cutaneous metastasis of ascending colon cancer harboring a BRAF V600E mutation: A rare case report. [Case Reports]
    Medicine (Baltimore). 2020 May 22; 99(21):e20026.Liao L, Cheng Q, … Ye S
  • CONCLUSIONS: Cutaneous metastasis of colorectal cancer with BRAF V600E mutation is a rare but important phenomenon that should not be ignored. Cutaneous metastasis of colorectal cancer frequently indicates advanced disease and poor prognosis. The SWOG 1406 program is one of the treatment options, but this needs further exploration.
  • Altered Mental Status: A Case Report of Toxic Leukoencephalopathy Following Heroin Exposure. [Journal Article]
    J Addict Med. 2020 May 27 [Online ahead of print]Weitzer D, Shmuts R, Khan M
  • : Toxic leukoencephalopathy is a rare illness that causes diffuse white matter destruction, and as a result may mimic psychiatric disorders. Multiple causes have been identified including nerve related injury from exposure to a toxin. When symptoms present, they typically improve after the offending agent is eliminated. However, the clinical presentation in this report is unique in that the syndr…
  • Vitamin D can prevent COVID-19 infection-induced multiple organ damage. [Letter]
    Naunyn Schmiedebergs Arch Pharmacol. 2020 07; 393(7):1157-1160.Aygun H
  • Vitamin D is an immunomodulator hormone with an anti-inflammatory and antimicrobial effect with a high safety profile. A lot of COVID-19 infected patients develop acute respiratory distress syndrome (ARDS), which may lead to multiple organ damage. These symptoms are associated with a cytokine storm syndrome. The aim of this letter is to note the 5 crucial points that vitamin D could have protecti…
  • [Hypoparathyroidism treated with recombinant human parathyroid hormone [rhPTH(1-84)]]. [Case Reports]
    Medicina (B Aires). 2020; 80(3):289-291.Ramacciotti CF, Pereyra MC, Cohen EN
  • Hypoparathyroidism (HypoPT) is a rare disease characterized by low calcium and inappropriately low circulating parathormone levels. We present the case of a 25-year-old high-performance athlete male, with history of HypoPT after total thyroidectomy for papillary thyroid carcinoma (T3 N1b M0) two years before, who was referred to our clinic for symptomatic hypocalcemia. The patient reported serum …
  • Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review. [Review]
    JAMA. 2020 May 19; 323(19):1945-1960.Armstrong AW, Read C
  • CONCLUSIONS: Psoriasis is an inflammatory skin disease that is associated with multiple comorbidities and substantially diminishes patients' quality of life. Topical therapies remain the cornerstone for treating mild psoriasis. Therapeutic advancements for moderate to severe plaque psoriasis include biologics that inhibit TNF-α, p40IL-12/23, IL-17, and p19IL-23, as well as an oral phosphodiesterase 4 inhibitor.
  • A Micro-Longitudinal Approach to Measuring Medication Adherence in Pediatric Inflammatory Bowel Diseases. [Journal Article]
    J Pediatr Gastroenterol Nutr. 2020 May 12 [Online ahead of print]Plevinsky JM, Denson LA, … Hommel KA
  • Measuring medication adherence in pediatric inflammatory bowel diseases (IBD) is challenging due to complexities in personalized treatment regimens and increased use of biologic mono- and combination therapy. Objective measurement of adherence via electronic monitoring is the gold standard; however, it is not useful for daily monitoring when multiple medication formulations (e.g., pills, injectio…
  • Micronutrient status during paediatric critical illness: A scoping review. [Review]
    Clin Nutr. 2020 Apr 22 [Online ahead of print]Marino LV, Valla FV, … Verbruggen SCAT
  • CONCLUSIONS: During critical illness, micronutrients should be provided in sufficient amounts to meet reference nutrient intakes for age. Although, there is insufficient data to recommend routine supplementations of micronutrients at higher doses during critical illness, the 'absence of evidence should not imply evidence of absence', and well designed prospective studies are urgently needed to elucidate paediatric micronutrient requirements during critical illness. The absence of reliable biomarkers make it challenging to determine whether low serum levels are reflective of a true deficiency or as a result redistribution, particularly during the acute phase of critical illness. As more children continue to survive a PICU admission, particularly those with complex diseases micronutrient supplementation research should also be inclusive of the recovery phase following critical illness.
  • Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment. [Journal Article]
    Biomolecules. 2020 Apr 29; 10(5)Hwang ES, Song SB
  • Nicotinamide (NAM) at doses far above those recommended for vitamins is suggested to be effective against a wide spectrum of diseases and conditions, including neurological dysfunctions, depression and other psychological disorders, and inflammatory diseases. Recent increases in public awareness on possible pro-longevity effects of nicotinamide adenine dinucleotide (NAD+) precursors have caused f…
  • Case report of holocarboxylase synthetase deficiency (late-onset) in 2 Chinese patients. [Case Reports]
    Medicine (Baltimore). 2020 May; 99(18):e19964.Xiong Z, Zhang G, … Zheng J
  • CONCLUSIONS: Late-onset HCLS deficiency may present with obvious hyperglycemia. Human genetic analysis eventually provided a definite diagnosis. Prompt treatment with biotin is vital to correct metabolic imbalances, and continued therapy is essential to the improving long-term prognoses. Their mutations were p.R508W and c.1088T > A, and these mutations might represent hot-spot genes in Chinese populations with HCLS deficiency. The variants c.1484T > G(p.L495*) and c.835G > T(p.E279x) are likely pathogenic, and more studies are needed to confirm these results.
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