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24 results
  • Whole-Slide Image Focus Quality: Automatic Assessment and Impact on AI Cancer Detection. [Journal Article]
    J Pathol Inform. 2019; 10:39.Kohlberger T, Liu Y, … Stumpe MC
  • CONCLUSIONS: Comprehensive whole-slide OOF categorization could enable rescans before pathologist review, potentially reducing the impact of digitization focus issues on the clinical workflow. We show that the algorithm trained on our semi-synthetic OOF data generalizes well to real OOF regions across tissue types, stains, and scanners. Finally, quantitative OOF maps can flag regions that might otherwise be misclassified by image analysis algorithms, preventing OOF-induced errors.
  • Technical challenges of quantitative chest MRI data analysis in a large cohort pediatric study. [Journal Article]
    Eur Radiol. 2019 Jun; 29(6):2770-2782.Nguyen AH, Perez-Rovira A, … Ciet P
  • CONCLUSIONS: Volume overestimation of MRI due to GD can be quantified. Semi-automated and fully automated segmentation methods allow accurate, reproducible, and fast lung volume quantification. Chest MRI can be a valid radiation-free imaging modality for lung segmentation and volume quantification in large cohort studies.• Geometric distortion varies according to MRI setting and patient positioning. • Automated segmentation methods allow fast and accurate lung volume quantification. • MRI is a valid radiation-free alternative to CT for quantitative data analysis.
  • The effect of fine motor skills on handwriting legibility in preschool age children. [Journal Article]
    J Phys Ther Sci. 2018 Feb; 30(2):324-327.Seo SM
  • [Purpose] The purpose of this study was to examine the effect that fine motor skills have on handwriting legibility in children of preschool age. [Subjects and Methods] The subjects of this study were 52 children of normal growth and development. In order to ascertain handwriting legibility, a Korean alphabet writing assessment was used; to measure fine motor skills, fine motor precision and manu…
  • AMAS: a fast tool for alignment manipulation and computing of summary statistics. [Journal Article]
    PeerJ. 2016; 4:e1660.Borowiec ML
  • The amount of data used in phylogenetics has grown explosively in the recent years and many phylogenies are inferred with hundreds or even thousands of loci and many taxa. These modern phylogenomic studies often entail separate analyses of each of the loci in addition to multiple analyses of subsets of genes or concatenated sequences. Computationally efficient tools for handling and computing pro…
  • Autonomous Document Cleaning--A Generative Approach to Reconstruct Strongly Corrupted Scanned Texts. [Journal Article]
    IEEE Trans Pattern Anal Mach Intell. 2014 Oct; 36(10):1950-62.Dai Z, Lücke J
  • We study the task of cleaning scanned text documents that are strongly corrupted by dirt such as manual line strokes, spilled ink, etc. We aim at autonomously removing such corruptions from a single letter-size page based only on the information the page contains. Our approach first learns character representations from document patches without supervision. For learning, we use a probabilistic ge…
  • Development of a Portable Two-Way Communication and Information Device for Deafblind People. [Journal Article]
    Stud Health Technol Inform. 2015; 217:518-25.Ozioko O, Hersh M
  • This paper presents research on the development of a wearable two-way communication and information device for deafblind people who use tactile communications methods, namely the British deafblind manual alphabet and/or Braille. The device has two components: a glove worn by the deafblind person and a handheld display with keypad to be used by their hearing and sighted communication partner. User…
  • BLSSpeller: exhaustive comparative discovery of conserved cis-regulatory elements. [Journal Article]
    Bioinformatics. 2015 Dec 01; 31(23):3758-66.De Witte D, Van de Velde J, … Fostier J
  • The accurate discovery and annotation of regulatory elements remains a challenging problem. The growing number of sequenced genomes creates new opportunities for comparative approaches to motif discovery. Putative binding sites are then considered to be functional if they are conserved in orthologous promoter sequences of multiple related species. Existing methods for comparative motif discovery …
  • ProFET: Feature engineering captures high-level protein functions. [Journal Article]
    Bioinformatics. 2015 Nov 01; 31(21):3429-36.Ofer D, Linial M
  • The amount of sequenced genomes and proteins is growing at an unprecedented pace. Unfortunately, manual curation and functional knowledge lag behind. Homologous inference often fails at labeling proteins with diverse functions and broad classes. Thus, identifying high-level protein functionality remains challenging. We hypothesize that a universal feature engineering approach can yield classifica…
  • Small-world networks and disturbed functional connectivity in schizophrenia. [Journal Article]
    Schizophr Res. 2006 Oct; 87(1-3):60-6.Micheloyannis S, Pachou E, … Zervakis M
  • Disturbances in "functional connectivity" have been proposed as a major pathophysiological mechanism for schizophrenia, and in particular, for cognitive disorganization. Detection and estimation of these disturbances would be of clinical interest. Here we characterize the spatial pattern of functional connectivity by computing the "synchronization likelihood" (SL) of EEG at rest and during perfor…
  • Timing of muscle activation in a hand movement sequence. [Journal Article]
    Cereb Cortex. 2007 Apr; 17(4):803-15.Klein Breteler MD, Simura KJ, Flanders M
  • Recent studies have described muscle synergies as overlapping, multimuscle groups defined by synchronous covariation in activation intensity. A different approach regards a synergy as a fixed temporal sequence of bursts of activity across groups of motoneurons. To pursue this latter definition, the present study used a principal component (PC) analysis tailored to reveal the across-muscle tempora…
  • Muscular and postural synergies of the human hand. [Journal Article]
    J Neurophysiol. 2004 Jul; 92(1):523-35.Weiss EJ, Flanders M
  • Because humans have limited ability to independently control the many joints of the hand, a wide variety of hand shapes can be characterized as a weighted combination of just two or three main patterns of covariation in joint rotations, or "postural synergies." The present study sought to align muscle synergies with these main postural synergies and to describe the form of membership of motor uni…
  • Biological constraints simplify the recognition of hand shapes. [Clinical Trial]
    IEEE Trans Biomed Eng. 2003 Feb; 50(2):265-9.Jerde TE, Soechting JF, Flanders M
  • This study sought to identify constraints that might lead to a concise system of recognizing fingerspelling hand shapes. Previous studies of grasping suggested that hand shape is controlled using combinations of a small number of neuromuscular synergies, but fingerspelling shapes appear to be more highly individuated and, therefore, might require a larger number of degrees of freedom. Static hand…
  • A comparison of imitation strategies in observational learning of action patterns. [Journal Article]
    J Mot Behav. 1996 Dec; 28(4):348-58.Weeks DL, Hall AK, Anderson LP
  • The effects of different arrangements of demonstration and imitation of modeled actions on the learning of the 26 handshapes of the American manual alphabet were investigated. A concurrent group (N =16), which imitated handshapes concurrently with their demonstration, was compared with a delayed group (N = 16), which delayed imitation until 3 handshapes had been displayed, and with a combination …
  • Adapted cuing technique: facilitating sequential phoneme production. [Review]
    Clin Commun Disord. 1994 Sep; 4(3):183-9.Klick SL
  • ACT is a visual cuing technique designed to facilitate dyspraxic speech by highlighting the sequential production of phonemes. In using ACT, cues are presented in such a way as to suggest sequential, coarticulatory movement in an overall pattern of motion. While using ACT, the facilitator's hand moves forward and back along the side of her (or his) own face. Finger movements signal specific speec…
  • A study of the tactual and visual reception of fingerspelling. [Journal Article]
    J Speech Hear Res. 1990 Dec; 33(4):786-97.Reed CM, Delhorne LA, … Fischer SD
  • A method of communication in frequent use among members of the deaf-blind community is the tactual reception of fingerspelling. In this method, the hand of the deaf-blind individual is placed on the hand of the sender to monitor the handshapes and movements associated with the letters of the manual alphabet. The purpose of the current study was to examine the ability of experienced deaf-blind sub…
  • Brain function and writing with the unaccustomed left hand. [Journal Article]
    J Forensic Sci. 1985 Jan; 30(1):167-71.Dawson GA
  • Twenty right-handed subjects were asked to handprint a passage containing all the letters of the alphabet once with each hand. The purpose was to describe the changes a document examiner can expect to find in handprinting done with the unaccustomed left hand and to offer a hypothesis as to why these changes occur. It was found that many of the writers displayed persistent differences between thei…
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