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(Marchiafava Micheli syndrome)
3,662 results
  • Diagnosing nocturnal paroxysmal hemoglobinuria: a single-center 4-year experience. [Journal Article]
  • IJInt J Lab Hematol 2017 Apr 13
  • Mercier T, Devos T, … Boeckx N
  • CONCLUSIONS: Our findings reinforce guidelines from the International PNH Interest Group which suggest testing for PNH in the setting of unusual thrombosis, HA, aplastic/hypoplastic bone marrow disorders, or MDS, as these have a higher pretest probability. This probability drops to zero in our study in nonrecommended indications. This reflects the need for better education of clinicians about the disease PNH and the indications for diagnostic testing.
  • Multicenter validation of a simplified method for paroxysmal nocturnal hemoglobinuria screening. [Journal Article]
  • EJEur J Haematol 2017 Mar 23
  • Gatti A, Del Vecchio L, … Brando B
  • CONCLUSIONS: A simplified two-color (FLAER/CD15) PNH screening test has been validated in a highly standardized multicenter study and proved feasible and effective in ongoing regional programs. Precision, sensitivity, and specificity of the simplified test for granulocytes were comparable to the more complex and expensive six-color assay and applicable for screening also in peripheral laboratories. The diagnostic confirmation of PNH should be always performed by a reference center using the established technique on all cell lineages.
  • Paroxysmal nocturnal haemoglobinuria in a patient with primary Budd-Chiari syndrome: a contraceptive challenge. [Journal Article]
  • EJEur J Contracept Reprod Health Care 2017; 22(2):152-155
  • Friedmann I, Balayla J
  • CONCLUSIONS: Budd-Chiari syndrome is defined by the presence of hepatic venous outflow tract obstruction, which may be due to a number of underlying causes. PNH is a rare, acquired, life-threatening disease characterised by red blood cell destruction (haemolytic anaemia), blood clots (thrombosis) and impaired bone marrow function. PNH is a known underlying cause of Budd?Chiari syndrome. Patients with PNH carry an increased risk of mortality, particularly during pregnancy. As such, pregnancy is absolutely contraindicated in these patients, who require strict contraceptive regimens. However, the presence of both PNH and Budd?Chiari syndrome limits contraceptive choices and poses a contraceptive challenge.
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