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729 results
  • Repurposing the inhibitors of COVID-19 key proteins through molecular docking approach. [Journal Article]
    Process Biochem. 2021 Nov; 110:216-222.Alghamdi HA, Attique SA, … Nawaz MZ
  • The severe acute respiratory syndrome coronavirus 2, famous as COVID-19, has recently emerged as a novel virus and imposed an unrecoverable loss to global health and the economy. At present, no effective drug against COVID-19 is available and currently available viral drugs targeting the viral key proteins of related RNA viruses have been found ineffective against COVID-19. This study evaluated t…
  • Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers. [Journal Article]
    ACS Appl Mater Interfaces. 2021 Aug 25; 13(33):38969-38978.Ruiz-Cantu L, F Trindade G, … Wildman RD
  • Controlling the microstructure of materials by means of phase separation is a versatile tool for optimizing material properties. Phase separation has been exploited to fabricate intricate microstructures in many fields including cell biology, tissue engineering, optics, and electronics. The aim of this study was to use phase separation to tailor the spatial location of drugs and thereby generate …
  • Pulmonary adverse drug event data in hypertension with implications on COVID-19 morbidity. [Journal Article]
    Sci Rep. 2021 06 25; 11(1):13349.Jaberi-Douraki M, Meyer E, … Xu X
  • Hypertension is a recognized comorbidity for COVID-19. The association of antihypertensive medications with outcomes in patients with hypertension is not fully described. However, angiotensin-converting enzyme 2 (ACE2), responsible for host entry of the novel coronavirus (SARS-CoV-2) leading to COVID-19, is postulated to be upregulated in patients taking angiotensin-converting enzyme inhibitors (…
  • Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury. [Journal Article]
    Lab Invest. 2020 11; 100(11):1455-1464.Prieto-García L, Vicente-Vicente L, … López-Hernández FJ
  • Simultaneous administration of certain antihypertensive (renin-angiotensin system inhibitors and diuretics) and nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a renal toxicity syndrome known as "triple whammy" acute kidney injury (TW-AKI), yet poorly characterized at the pathophysiological level, as no specific experimental model exists on which to conduct preclinical research. …
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Angiotensin-Converting Enzyme Inhibitors [BOOK]
    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The angiotensin-converting enzyme (ACE) inhibitors are a widely used class of antihypertensive medications that act by blocking the conversion of angiotensin I to angiotensin II, thus inhibiting an intermediate step in the renin-angiotensin pathway. The ACE inhibitors are rare causes of clinically apparent liver injury. The ACE inhibitors act by blocking the conversion of angiotensin I to angiote…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Trandolapril [BOOK]
    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Trandolapril is an oral angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and heart failure. Trandolapril is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute liver injury.
  • Genome-wide association analysis of common genetic variants of resistant hypertension. [Randomized Controlled Trial]
    Pharmacogenomics J. 2019 06; 19(3):295-304.El Rouby N, McDonough CW, … Johnson JA
  • Resistant hypertension (RHTN), defined as uncontrolled blood pressure (BP) ≥ 140/90 using three or more drugs or controlled BP (<140/90) using four or more drugs, is associated with adverse outcomes, including decline in kidney function. We conducted a genome-wide association analysis in 1194 White and Hispanic participants with hypertension and coronary artery disease from the INternational VEra…
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