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2,892 results
  • Persistence of Burkholderia thailandensis E264 in lung tissue after a single binge alcohol episode. [Journal Article]
    PLoS One 2019; 14(12):e0218147Jimenez VM, Settles EW, … Monroy FP
  • CONCLUSIONS: Our results indicate that the effects of a single binge alcohol episode are tissue specific. A single binge alcohol intoxication event increases bacterial colonization in mouse lung tissue even after very low BACs and decreases the dose required to colonize the lungs with less virulent B. thailandensis. Additionally, the temporal effects of binge alcohol alters lung and spleen cytokine expression for at least 24 h after alcohol is detected in the blood. Delayed recovery in lung and not spleen tissue may provide a means for B. pseudomallei and near-neighbors to successfully colonize lung tissue through increased intracellular invasion of non-phagocytic cells in patients with hazardous alcohol intake.
  • Caspase-4 mediates restriction of Burkholderia pseudomallei in human alveolar epithelial cells. [Journal Article]
    Infect Immun 2019Srisaowakarn C, Pudla M, … Utaisincharoen P
  • Melioidosis is an infectious disease with a high mortality rate responsible for community-acquired sepsis in Southeast Asia and Northern Australia. The causative agent of this disease is Burkholderia pseudomallei, a gram-negative bacterium that resides in soil and contaminated natural water. After entering into host cells, the bacteria escape into the cytoplasm which has numerous cytosolic sensor…
  • Melioidosis - A Case Series from Kerala. [Journal Article]
    J Assoc Physicians India 2019; 67(12):40-43George E, Rajalakshmi A
  • Melioidosis is an infectious disease caused by gram negative bacterium Burkholderia pseudomallei. It is a soil and water pathogen and transmitted to humans through inoculation or inhalation. This disease is considered endemic in India and largely remains under reported. The most common presentation is pneumonia and bacteraemia, which can present acutely and as septic shock. Chronic presentation i…
  • A rare case of Sweet syndrome secondary to melioidosis. [Journal Article]
    BMC Dermatol 2019; 19(1):16Vithoosan S, Thanushah B, … Jayanaga A
  • CONCLUSIONS: Sweet syndrome is an uncommon inflammatory disorder known to be associated with upper respiratory tract and gastrointestinal infections, malignancies and the use of certain drugs. Melioidosis is an emerging infection with various cutaneous manifestations. This is the first case of melioidosis causing the secondary sweet syndrome. It emphasizes the importance of considering melioidosis as a potential aetiology in patients with Sweet syndrome.
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