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(Mesulam syndrome)
1,423 results
  • Establishing links between abnormal eating behaviours and semantic deficits in dementia. [Journal Article]
    J Neuropsychol 2019Vignando M, Rumiati RI, … Aiello M
  • The hypothesis that semantic deficits in dementia may contribute in producing changes in eating preferences has never been experimentally investigated despite this association has been clinically observed. We administered tasks assessing semantic memory and the Appetite and Eating Habits Questionnaire (APEHQ) to 23 patients with dementia (behavioural frontotemporal dementia, primary progressive a…
  • Neurodegenerative disorders of the human frontal lobes. [Journal Article]
    Handb Clin Neurol 2019; 163:391-410Butler PM, Chiong W
  • The frontal lobes play an integral role in human socioemotional and cognitive function. Sense of self, moral decisions, empathy, and behavioral monitoring of goal-states all depend on key nodes within frontal cortex. While several neurodegenerative diseases can affect frontal function, frontotemporal dementia (FTD) has particularly serious and specific effects, which thus provide insights into th…
  • Perturbations of language network connectivity in primary progressive aphasia. [Journal Article]
    Cortex 2019Bonakdarpour B, Hurley RS, … Mesulam MM
  • Aphasias are caused by disruption in structural integrity and interconnectivity within a large-scale distributed language network. We investigated the distribution and behavioral consequences of altered functional connectivity in three variants of primary progressive aphasia (PPA). The goal was to clarify relationships among atrophy, resting connectivity, and the resulting behavioral changes in 7…
  • Northwestern Anagram Test-Italian (Nat-I) for primary progressive aphasia. [Journal Article]
    Cortex 2019; 119:497-510Canu E, Agosta F, … Filippi M
  • CONCLUSIONS: The NAT-I, in particular the measure of non-canonical syntax, is an effective tool for distinguishing nfvPPA and lvPPA patients and correlated with the integrity of crucial brain regions implicated in syntactic processing. The 22-item-brief version of NAT-I is suitable for clinical practice and research.
  • Verb-argument integration in primary progressive aphasia: Real-time argument access and selection. [Journal Article]
    Neuropsychologia 2019; 134:107192Mack JE, Mesulam MM, … Thompson CK
  • CONCLUSIONS: This study revealed two distinct patterns of impaired verb-argument integration in PPA. In PPA-S, impaired verb-argument integration was observed in the argument access experiment, indicating impairments in basic semantic combinatory processes which likely relate to damage in ventral language pathways. In contrast, listeners with PPA-G showed marked impairments of argument selection, likely relating to damage to left inferior frontal regions.
  • Networks Disrupted in Linguistic Variants of Frontotemporal Dementia. [Journal Article]
    Front Neurol 2019; 10:903Reyes PA, Rueda ADP, … Matallana DL
  • The non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) and semantic variant (svPPA) of frontotemporal dementia (FTD) are neurodegenerative diseases. Previous works have shown alterations of fractional anisotropy (FA) and mean diffusivity (MD) from diffusion tensor images (DTIs). This manuscript is aimed at using DTI images to build a global tractography and to identify atrophy …
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