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(Metastases to meninges)
844 results
  • Brain Tumors. [Review]
  • AJAm J Med 2018 Jan 22
  • McFaline-Figueroa JR, Lee EQ
  • Brain tumors are common, requiring general medical providers to have a basic understanding of their diagnosis and management. The most prevalent brain tumors are intracranial metastases from systemic...
  • Metastatic non-muscle invasive bladder cancer with meningeal carcinomatosis: case report of an unexpected response. [Journal Article]
  • BCBMC Cancer 2017 May 11; 17(1):323
  • Teyssonneau D, Daste A, … Gross-Goupil M
  • CONCLUSIONS: Metastasis in non-muscle invasive urothelial carcinoma is rare. Meningeal carcinomatosis outcome is poor, usually appearing in widely metastatic and progressive cancers but also because most systemic agents fail to pass the blood-brain barrier and penetrate into the cerebrospinal fluid. We described an unexpected response with complete response after chemotherapy for meningeal carcinomatosis of non muscle invasive urothelial carcinoma.
  • Overexpression of syndecan-1, MUC-1, and putative stem cell markers in breast cancer leptomeningeal metastasis: a cerebrospinal fluid flow cytometry study. [Journal Article]
  • BCBreast Cancer Res 2017 Apr 11; 19(1):46
  • Cordone I, Masi S, … Pace A
  • CONCLUSIONS: Flow cytometry can be successfully employed for solid tumor LM characterization even in CSF samples with low cell count. This in vivo study documents that CSF floating BC cells overexpress prognostic and putative cancer stem cell biomarkers related to tumor invasiveness, potentially representing a molecular target for circulating tumor cell detection and LM treatment monitoring, as well as a primary target for innovative treatment strategies. The T lymphocyte infiltration, documented in all CSF samples, suggests a possible involvement of the CNS lymphatic system in both lymphoid and cancer cell migration into and out of the meninges, supporting the extension of a new form of cellular immunotherapy to LM. Due to the small number of cases, validation on large cohorts of patients are warranted to confirm these findings and to evaluate the impact and value of these results for diagnosis and management of LM.
  • Neoplastic Meningitis Due to Lung, Breast, and Melanoma Metastases. [Review]
  • CCCancer Control 2017; 24(1):22-32
  • Le Rhun E, Taillibert S, Chamberlain MC
  • CONCLUSIONS: The prognosis of neoplastic meningitis remains poor. The increasing use of novel, targeted therapies and immunotherapy in solid tumors and its impact on neoplastic meningitis remains to be determined and is an area of active research. Thus, well conducted trials are needed.
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