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(Micronutrients in Health and Disease)
614 results
  • The Role of Brain Barriers in Maintaining Brain Vitamin Levels. [Journal Article]
    Annu Rev Nutr 2019; 39:147-173Tiani KA, Stover PJ, Field MS
  • It is increasingly recognized that tissue-specific nutrient deficiencies can exist in the absence of whole-body deficiency and that these deficiencies may result from disease or disease-related physiological processes. Brain and central nervous system tissues require adequate nutrient levels to function. Many nutrients are concentrated in the cerebrospinal fluid relative to the serum in healthy i…
  • Role of the chanzyme TRPM7 in the nervous system in health and disease. [Review]
    Cell Mol Life Sci 2019; 76(17):3301-3310Abumaria N, Li W, Clarkson AN
  • The channel kinase (chanzyme) transient receptor potential melastatin-like 7 (TRPM7) has a unique dual protein structure composed of an ion channel with an α-kinase domain on its C-terminus. In the nervous system, under physiological conditions, TRPM7 contributes to critical neurobiological processes ranging from synaptic transmission to cognitive functions. Following certain pathological trigger…
  • Cardiomyocyte hepcidin: From intracellular iron homeostasis to physiological function. [Review]
    Vitam Horm 2019; 110:189-200Lakhal-Littleton S
  • Cellular iron is required for the utilization of oxygen in the cell. Iron in iron-sulfur and heme groups is required for electron transfer and oxygen activation in oxidative phosphorylation, while labile free iron is required for oxygen activation by dioxygenases, and as a catalyst for redox signaling. At the same time, this reactivity with oxygen underpins the production of cell-damaging free ra…
  • Hepcidin-ferroportin axis in health and disease. [Review]
    Vitam Horm 2019; 110:17-45Ginzburg YZ
  • Hepcidin is central to regulation of iron metabolism. Its effect on a cellular level involves binding ferroportin, the main iron export protein, resulting in its internalization and degradation and leading to iron sequestration within ferroportin-expressing cells. Aberrantly increased hepcidin leads to systemic iron deficiency and/or iron restricted erythropoiesis. Furthermore, insufficiently ele…
  • Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease. [Review]
    Int J Mol Sci 2019; 20(4)Halder M, Petsophonsakul P, … Schurgers L
  • Vitamin K is an essential bioactive compound required for optimal body function. Vitamin K can be present in various isoforms, distinguishable by two main structures, namely, phylloquinone (K1) and menaquinones (K2). The difference in structure between K1 and K2 is seen in different absorption rates, tissue distribution, and bioavailability. Although differing in structure, both act as cofactor f…
  • Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions. [Review]
    Int J Mol Sci 2018; 20(1)Sánchez-López C, Rossetti G, … Carloni P
  • The N-terminus of the prion protein is a large intrinsically disordered region encompassing approximately 125 amino acids. In this paper, we review its structural and functional properties, with a particular emphasis on its binding to copper ions. The latter is exploited by the region's conformational flexibility to yield a variety of biological functions. Disease-linked mutations and proteolytic…
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