- Clinical features, antiviral treatment and patient outcomes: a systematic review and comparative analysis of the previous and the 2022 mpox outbreaks. [Journal Article]J Infect Dis. 2023 Feb 03 [Online ahead of print]JI
- CONCLUSIONS: These findings are important for better understanding the disease and guiding adequate response to mpox outbreaks.
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- A case of occupational transmission of mpox. [Journal Article]Infection. 2023 Feb 03 [Online ahead of print]I
- CONCLUSIONS: Mpox can potentially be transmitted in an occupational context. Medical personnel should be informed about this possible route of transmission.
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- Clinicopathologic Features of Human Monkeypox Lymphadenitis. [Letter]Histopathology. 2023 Feb 03 [Online ahead of print]H
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- Sexual behaviors, cannabis, alcohol and monkeypox infection. [Review]Front Public Health. 2022; 10:1054488.FP
- The emergence of the monkeypox virus (MPXV) outbreak in 2022 is a worldwide health issue. The rapid increase of monkeypox cases caused the WHO to designate the escalating global monkeypox outbreak a Public Health Emergency of International Concern on July 23, 2022. The WHO has called on the group currently most affected by the virus, men who have sex with men (MSM), to limit their sexual partners…
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- Genomic Analysis of Early Monkeypox Virus Outbreak Strains, Washington, United States. [Journal Article]Emerg Infect Dis. 2023 Feb 02; 29(3)EI
- We conducted a genomic analysis of monkeypox virus sequences collected early in the 2022 outbreak, during July-August , in Washington, USA. Using 109 viral genomes, we found low overall genetic diversity, multiple introductions into the state, ongoing community transmission, and potential for co-infections by multiple strains.
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- Possible Mpox Protection from Smallpox Vaccine-Generated Antibodies among Older Adults. [Journal Article]Emerg Infect Dis. 2023 Feb 02; 29(3)EI
- Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was among persons 71-80 years of age. Low antibody levels in 31.5% of this population indicates that addressing their vaccination should be a priority.
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- Monkeypox: is topical cidofovir a good idea? [Journal Article]Clin Exp Dermatol. 2023 Feb 02; 48(2):132-134.CE
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- Characteristics and clinical manifestations of monkeypox among people with and without HIV in the United States: A retrospective cohort. [Journal Article]AIDS. 2022 Nov 30 [Online ahead of print]AIDS
- CONCLUSIONS: PWH had higher rates of clinical manifestations and required greater utilization of healthcare resources for any reason compared to those without HIV.
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- Monkeypox Infection with primarily mucosal involvement. [Journal Article]Sex Transm Dis. 2022 Dec 06 [Online ahead of print]ST
- Since May 2022, several non-endemic countries face a monkeypox outbreak, with clinic and epidemiological characteristics distinct from the classic ones. Primarily affecting the sexually active population, these cases present with mucocutaneous lesions mainly localized in perioral, genital, and anal areas. A retrospective study was conducted in a tertiary center in Lisbon, to characterize the popu…
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- Environmental perspectives of monkeypox virus: correspondence. [Letter]Rev Environ Health. 2023 Feb 02 [Online ahead of print]RE
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- Monkeypox-Associated Disciform Keratitis. [Journal Article]Cornea. 2022 Dec 09 [Online ahead of print]C
- CONCLUSIONS: MPX may cause disciform keratitis and scarring that closely resembles other ocular viral infections. Clinical trials are urgently needed to define the optimal management of human MPX infections and reduce vision loss.
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- Clinical description of sixty-six cases of monkeypox virus (MKPV) infection among men who have sex with men (MSM), in an HIV/PrEP French Clinic. [Journal Article]J Acquir Immune Defic Syndr. 2022 Dec 14 [Online ahead of print]JA
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- Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential. [Journal Article]Expert Rev Anti Infect Ther. 2023 Feb 02 [Online ahead of print]ER
- Tecovirimat oral capsule formulation is approved in the US and Canada for treatment of smallpox and in the United Kingdom (UK) and European Union (EU) for treatment of multiple human orthopoxvirus diseases, including mpox. Smallpox is considered a serious threat, and there is currently an unprecedented global mpox outbreak.
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- Human MPox (Monkeypox) Virus Membranous Keratoconjunctivitis With Transient Corneal Hypoesthesia and Late Symblepharon Formation: A Novel Case and Clinical Implications. [Journal Article]Cornea. 2023 Jan 11 [Online ahead of print]C
- CONCLUSIONS: Early corneal involvement of human monkeypox virus is possible. Transient corneal hypoesthesia may be due to acute inflammation. Chronic inflammatory changes can result in symblepharon. These findings have potential implications in patient care and corneal donation.
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- Monkeypox keratoconjunctivitis with associated Wessley immune ring in an immunocompetent patient. [Letter]J Med Virol. 2023 Feb 02 [Online ahead of print]JM
- Monkeypox is a neglected zoonotic disease caused by Monkeypox virus (MPXV), a double-stranded DNA virus of the genus Orthopoxvirus. Here we present a case report of a 32-year-old man with MPXV infection who developed keratoconjunctivitis and Wessley immune ring with no identifiable cause other than ocular involvement by MPXV. We highlight the need of ophthalmologists exploring any ocular symptoms…
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- Monkeypox Vaccination Strategy and Missed Opportunities in STI and HIV Prevention: An Urban Sexual Health Clinic's Experience During a Public Health Emergency. [Journal Article]
- Among individuals presenting for monkeypox vaccination, transition from an opt-out protocol for sexually transmitted infection (STI) and HIV risk assessment and testing to an opt-in protocol was associated with a substantial increase in missed opportunities for HIV pre-exposure prophylaxis and STI testing at an ambulatory sexual health clinic.
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- Monkeypox disease and pregnancy. Where are we today? A review of literature. [Review]J Perinatol. 2023 Feb 01 [Online ahead of print]JP
- Monkeypox has emerged as a significant human pathogen, posing severe risks in vulnerable populations. At present, there is not enough data available as to whether pregnant women are more vulnerable to monkeypox infection, or they suffer more severe symptoms, and studies on this issue as well as to the possible adverse effects on the developing fetus are limited. The aim of this review, was to bri…
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- Evaluation of differentially expressed genes during replication using gene expression landscape of monkeypox-infected MK2 cells: A bioinformatics and systems biology approach to understanding the genomic pattern of viral replication. [Journal Article]J Infect Public Health. 2023 Jan 25; 16(3):399-409.JI
- CONCLUSIONS: This study will help in better understanding the replication process, machinery, and genomic landscape of the virus. This will further aid the discovery and development of therapeutics against viruses.
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- Comment on clinical, histopathological and ultrastructural features of human monkeypox infection. [Journal Article]Clin Exp Dermatol. 2023 Feb 01 [Online ahead of print]CE
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- Gold-based paper for antigen detection of monkeypox virus. [Journal Article]Analyst. 2023 Jan 26 [Online ahead of print]A
- In 2022, the outbreak of the monkeypox virus occurred in many non-endemic countries, and the World Health Organization (WHO) assessed that this outbreak was "atypical". The establishment of a rapid and effective assay that can be used for the early diagnosis of monkeypox virus infection is crucial for outbreak prevention and control. In this study, the monkeypox virus A29 protein and the homologo…
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- Marburg virus disease: the paradox of Nigeria's preparedness and priority effects in co-epidemics. [Review]
- CONCLUSIONS: Paying attention to the lessons learned from previous (and current) multiple epidemics including Avian Influenza, Yellow fever, Ebola virus disease, Monkeypox, Lassa fever, and COVID-19 could help avoid a potentially devastating public health catastrophe in Nigeria.
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- The Mpox, serious menace, or paper tiger? [Review]
- One of the most horrible diseases in history, Smallpox is caused by the Variola from Poxvirus family, has caused great morbidity and mortality along the way since it was eradicated in the 20th century. During and after the eradication program for Variola, other Poxviruses such as the Monkeypox (Mpox) virus, which causes a smallpox-like disease, became flagrant. With its long range of enzymes and …
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- Outbreaks of human monkeypox during the COVID-19 pandemic: a systematic review for healthcare professionals. [Review]
- The ongoing 2022 multicountry monkeypox epidemic has drawn worldwide attention. Human monkeypox is a virus that spreads from animals to humans. It is an endemic disease in the rain forests of Central and West Africa. However, the disease recently emerged in India, and also in United States through imported wild rodents from Africa, even though the world is still struggling to escape from the clut…
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- Real-world effectiveness of a single dose of mpox vaccine in males. [Journal Article]Nat Med. 2023 Jan 31 [Online ahead of print]NMed
- The recent global outbreak of the monkeypox (mpox) virus in humans was declared a public health emergency by the World Health Organization in July 2022. The smallpox and mpox vaccine (JYNNEOS; Modified Vaccinia Ankara-Bavarian Nordic; MVA-BN), provided as a two-dose regimen, is currently the primary vaccine utilized against mpox. However, the efficacy of MVA-BN against mpox has never been demonst…
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- Monkeypox virus replication underlying circadian rhythm networks. [Review]
- The mammalian brain has an endogenous central circadian clock that regulates central and peripheral cellular activities. At the molecular level, this day-night cycle induces the expression of upstream and downstream transcription factors that influence the immune system and the severity of viral infections over time. In addition, there are also circadian effects on host tolerance pathways. This s…
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- Monkeypox-induced Myocarditis: A Systematic Review. [Review]
- CONCLUSIONS: Our study's findings show that all cases were reported among male patients with the most common symptoms of chest pain. The overall prognosis was good, with no mortality reported. Infected patients complaining of chest pain should not be ignored, and proper investigation of myocarditis must be considered.
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- Case Report: Monkeypox - Not Just a Rash. [Case Reports]Am J Trop Med Hyg. 2023 Jan 30 [Online ahead of print]AJ
- Mpox (formally monkeypox) is an Orthopoxvirus associated with both zoonotic and person-to-person spread. Human mpox classically presents with rash and systemic symptoms. Although sporadic outbreaks of mpox have occurred worldwide, the 2022 outbreak is the first of pandemic significance. Thousands of geographically dispersed cases were reported beginning in May 2022. The clinical presentations and…
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- 'Case of the Month' from the Medical University of Graz, Austria: pustules with ulceronecrotic centre - monkeypox virus is facing us. [Journal Article]BJU Int. 2023 Jan 30 [Online ahead of print]BI
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- Progression of human monkeypox infection despite tecovirimat in an immunocompromised adult. [Journal Article]Transpl Infect Dis. 2023 Jan 30 [Online ahead of print]TI
- We report a case of an immunocompromised man with monkeypox who experienced disease progression despite timely initiation of tecovirimat and ultimately required utilization of cidofovir and VIGIV for treatment. In immunocompromised patients, monkeypox might present with a more severe course of disease requiring consideration of alternative treatment strategies.
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