- Mpox vaccination and treatment: a systematic review. [Review]J Chemother. 2023 Dec 09 [Online ahead of print]JC
- The Human monkeypox virus (mpox) belongs to the Poxviridae family, characterized by double-stranded DNA. A 2022 outbreak, notably prevalent among men who have sex with men, was confirmed by the World Health Organization. To understand shifting prevalence patterns and clinical manifestations, we conducted a systematic review of recent animal and human studies. We comprehensively searched PubMed, S…
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- [Human monkeypox (Mpox)]. [Review]Dermatologie (Heidelb). 2023 Dec 08 [Online ahead of print]D
- Until recently, human monkeypox (Mpox) were rarely observed outside of Africa, where the Mpox virus (MPXV) is endemic in some regions. In early May 2022, a global Mpox outbreak occurred. Crucial to this outbreak was human-to-human transmission during sexual activity. In particular, young men who have sex with men (MSM) became ill. In July 2022, this Mpox epidemic was declared a public health emer…
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- Electrochemical Paper-Based Nanobiosensor for Rapid and Sensitive Detection of Monkeypox Virus. [Journal Article]ACS Appl Mater Interfaces. 2023 Dec 08 [Online ahead of print]AA
- Monkeypox virus (MPXV) infection was classified as a public health emergency of international concern by the World Health Organization (WHO) in 2022, being transmitted between humans by large respiratory droplets, in contact with skin lesions, fomites, and sexually. Currently, there are no available accessible and simple-to-use diagnostic tests that accurately detect MPXV antigens for decentraliz…
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- Estimation of Incubation Period of Mpox during 2022 Outbreak in Pereira, Colombia. [Journal Article]Emerg Infect Dis. 2023 Dec 08; 30(1)EI
- We estimated the incubation period for mpox during an outbreak in Pereira, Colombia, using data from 11 confirmed cases. Mean incubation period was 7.1 (95% CI 4.9-9.9) days, consistent with previous outbreaks. Accurately estimating the incubation period provides insights into transmission dynamics, informing public health interventions and surveillance strategies.
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- An In-silico Approach to Design and Validate SiRNA against Monkeypox Virus. [Journal Article]Curr Pharm Des. 2023 Dec 07 [Online ahead of print]CP
- CONCLUSIONS: Thus, the strategy may offer a platform for the development of potential antiviral RNA therapeutics that target MPXV at the genomic level.
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- No Varicella Zoster Virus Infection among Mpox Cases in Antwerp, Belgium. [Journal Article]Am J Trop Med Hyg. 2023 Dec 06; 109(6):1282-1283.AJ
- Several studies in tropical settings have reported that ∼20% of patients infected with Monkeypox virus (MPXV) also tested polymerase chain reaction (PCR) positive for Varicella zoster virus (VZV). Researchers have hypothesized that VZV infection predisposes to monkeypox (mpox), or vice versa, or that MPXV triggers the reactivation of VZV. We tested samples for VZV from a cohort of patients infect…
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- Exploration and Retrieval of Virus-Related Molecular Data Using ExTaxsI: The Monkeypox Use Case. [Journal Article]
- Retrieval and visualization of biological data are essential for understanding complex systems. With the increasing volume of data generated from high-throughput sequencing technologies, effective and optimized data visualization tools have become indispensable. This is particularly relevant in the COVID-19 postpandemic period, where understanding the diversity and interactions of microbial commu…
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- Perceptions and Knowledge of Public Towards Emerging Human Monkeypox in Yemen: A Cross-Sectional Study. [Journal Article]J Multidiscip Healthc. 2023; 16:3689-3701.JM
- CONCLUSIONS: The study reveals a low public knowledge about mpox in Yemen, emphasizing the need for targeted educational campaigns, especially via social media, to strengthen public health measures and disease control. Addressing Knowledge gaps and correcting misconceptions is crucial for improving preparedness and response to the disease.
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- Risk Factors for Hospitalization and Effect of Immunosuppression on Clinical Outcomes Among an Urban Cohort of Patients With Mpox. [Journal Article]Open Forum Infect Dis. 2023 Dec; 10(12):ofad533.OF
- CONCLUSIONS: Immunosuppression was a significant risk factor for hospitalization with mpox. PWH with CD4 T-cell counts <50/µL are at high risk of death due to mpox infection. Patients who are immunosuppressed should be considered for early and aggressive treatment of mpox, given the increased risk of hospitalization.
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- ASSESSING THE KNOWLEDGE OF SMALLPOX AND MONKEYPOX VIRUS AMONG THE UNIVERSITY OF TLEMCEN MEMBERS IN THE WAKE OF COVID-19: A 2023 CROSS-SECTIONAL STUDY. [Journal Article]Afr J Infect Dis. 2024; 18(1):5-10.AJ
- CONCLUSIONS: Although the MPXV may not become a pandemic, but knowing the various ways that contribute to its spread is essential to avoid any possibility of a new one, especially in Algeria.
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- Correction for Chiem et al., "Identification of In Vitro Inhibitors of Monkeypox Replication". [Journal Article]Microbiol Spectr. 2023 Dec 06 [Online ahead of print]MS
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- Serological methods for the detection of antibodies against monkeypox virus applicable for laboratories with different biosafety levels. [Journal Article]J Med Virol. 2023 Dec; 95(12):e29261.JM
- The monkeypox virus (MPXV) outbreak in 2022 has renewed interest in the detection of antibodies against orthopox viruses (OPXV) and MPXV, as serological methods can aid diagnostics and are key to epidemiological studies. Here three complementary serological methods are described with different strengths to aid the development and evaluation of in-house assays: An immunofluorescence assay (IFA) fo…
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- Stability of mpox virus on different commonly contacted surfaces. [Journal Article]J Med Virol. 2023 Dec; 95(12):e29296.JM
- Mpox is still spreading globally and is mostly reported to be transmitted by skin and mucosal contact. However, transmission through contact with fomites, contaminated objects, or surfaces has been reported in general population. Evaluation of the stability of mpox virus (MPXV) on different surfaces is important to minimize mpox transmission. In the study, the stability of MPXV on different kinds…
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- Exploring the dynamics of the 2022 mpox outbreak in Canada. [Journal Article]J Med Virol. 2023 Dec; 95(12):e29256.JM
- The 2022 mpox outbreak predominantly impacted gay, bisexual, and other men who have sex with men (gbMSM). Two models were developed to support situational awareness and management decisions in Canada. A compartmental model characterized epidemic drivers at national/provincial levels, while an agent-based model (ABM) assessed municipal-level impacts of vaccination. The models were parameterized an…
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- Mpox outbreak control indicators used in Ontario, Canada: May 21-December 10, 2022. [Journal Article]J Med Virol. 2023 Dec; 95(12):e29251.JM
- Since May 2022, over 91 000 cases of mpox have been reported globally with the majority of cases occurring among adult males who identify as gay, bisexual, or men who have sex with men (gbMSM). Given the rapid emergence of the global mpox outbreak, many public health authorities did not have established mpox outbreak control indicators or criteria for declaring an mpox outbreak over. Expert conse…
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- Lower rate of mpox vaccination hesitancy and medical consultation among Chinese men who have sex with men living with HIV in comparison with those living without HIV: A national observational study. [Journal Article]Hum Vaccin Immunother. 2023 Dec 15; 19(3):2290788.HV
- This anonymous cross-sectional study aimed to investigate the relationships between HIV infection and mpox-related focus issues among Chinese men who have sex with men (MSM). This study involved in 27 MSM social organizations and was conducted from July 31 to August 4, 2023. Mpox vaccination hesitancy was defined as the proportion of participants who expressed unwillingness to receive self-funded…
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- The diagnostic dilemma for atypical presentation of progressive human Mpox. [Case Reports]
- CONCLUSIONS: Suspicion for human mpox should be high in young MSM and PLHIV who present with rash and mpox should be ruled out earlier.
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- Mpox "Monkeypox" Virus: The Importance of Inclusive Imagery to Prevent Disease Stigma. [Journal Article]J Drugs Dermatol. 2023 Dec 01; 22(12):1235-1236.JD
- Since the initial coverage of the monkeypox virus, there has been debate among physicians over how to responsibly communicate public health information without harming historically marginalized communities. On November 28, 2022, the World Health Organization (WHO) announced its plan to rename monkeypox "mpox" following growing concern regarding the stigmatizing nature of the disease's original na…
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- A global systematic evidence review with meta-analysis of the epidemiological characteristics of the 2022 Mpox outbreaks. [Journal Article]
- CONCLUSIONS: The 2022 Mpox outbreaks presented with sex-related clinical manifestations and were mostly reported among MSM.
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- Targeted amplification-based whole genome sequencing of Monkeypox virus in clinical specimens. [Journal Article]Microbiol Spectr. 2023 Dec 04 [Online ahead of print]MS
- We present a protocol to efficiently sequence genomes of the MPXV-causing mpox. This enables researchers and public health agencies to acquire high-quality genomic data using a rapid and cost-effective approach. Genomic data can be used to conduct surveillance and investigate mpox outbreaks. We present 91 mpox genomes that show the diversity of the 2022 mpox outbreak in Ontario, Canada.
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- Direct metagenomic and amplicon-based Nanopore sequencing of French human monkeypox from clinical specimen. [Journal Article]Microbiol Resour Announc. 2023 Dec 04 [Online ahead of print]MR
- We report the whole-genome sequence of monkeypox virus obtained using MinION technology (Oxford Nanopore Technologies) from a French clinical specimen during the 2022 epidemic. Amplicon-based sequencing and shotgun metagenomic approaches were directly applied to the sample.
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- [Monkeypox transmission and oral prevention]. [Review]Shanghai Kou Qiang Yi Xue. 2023 Aug; 32(4):337-341.SK
- Monkeypox is becoming a viral infectious disease of global concern. WHO has reported monkeypox outbreaks in more than 50 countries. Since the first imported case has been confirmed and reported by Taiwan, China, in June 2022, the monkeypox has draw high attention from the national public health and epidemic prevention department. Among the key tasks of Shanghai high-quality healthcare development…
- letter to the editor: Cardiovascular Manifestations of Human Monkeypox Virus: An Updated Review. [Review]Curr Probl Cardiol. 2023 Dec 01 [Online ahead of print]CP
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- A case of fatal Monkeypox infection: necropsy and molecular findings, with some considerations related to clinical management. [Journal Article]Clin Microbiol Infect. 2023 Nov 30 [Online ahead of print]CM
- CONCLUSIONS: Monkeypox can manifest as an opportunistic infection in individuals with advanced HIV-associated immunosuppression.
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- Mpox DNA clearance in semen over 6-month follow-up. [Journal Article]J Med Virol. 2023 Dec; 95(12):e29259.JM
- Sexual intercourse is a well-established way of transmission of mpox infection. However, it is still uncertain whether semen may represent a viral reservoir. The aim of the study was to evaluate the clearance of viral DNA in semen samples from individuals diagnosed with mpox infection over 6-month follow-up. This prospective, observational, single-center study was conducted at IRCCS San Raffaele …
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- Using a theoretical framework of Intervention Mapping to inform public health communication messages designed to increase vaccination uptake; the example of mpox in the Netherlands. [Journal Article]
- CONCLUSIONS: IM provided a valuable tool in selecting communication methods to promote mpox vaccination uptake. These methods can be used to (more quickly) produce and implement a communication program in the context of possible future, vaccine-preventable, infectious disease outbreaks.
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- Extraction-free LAMP assays for generic detection of Old World Orthopoxviruses and specific detection of Mpox virus. [Journal Article]
- Mpox is a neglected zoonotic disease endemic in West and Central Africa. The Mpox outbreak with more than 90,000 cases worldwide since 2022 generated great concern about future outbreaks and highlighted the need for a simple and rapid diagnostic test. The Mpox virus, MPV, is a member of the Orthopoxvirus (OPV) genus that also contains other pathogenic viruses including variola virus, vaccinia vir…
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- Global prediction for mpox epidemic. [Journal Article]Environ Res. 2023 Nov 28 [Online ahead of print]ER
- The mpox epidemic had spread worldwide and become an epidemic of international concern. Before the emergence of targeted vaccines and specific drugs, it is necessary to numerically simulate and predict the epidemic. In order to better understand and grasp its transmission situation, and take some countermeasures accordingly when necessary, we predicted and simulated mpox transmission, vaccination…
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- Preparing for mpox resurgence: Surveillance lessons from outbreaks in Toronto, Canada. [Journal Article]J Infect Dis. 2023 Nov 30 [Online ahead of print]JI
- CONCLUSIONS: This investigation demonstrates the importance of ongoing surveillance and preparedness for mpox outbreaks. Undetected local transmission was not a likely source of the 2022-2023 resurgence. Ongoing pre-exposure vaccine promotion remains important to mitigate disease burden.
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- Mpox (monkeypox) risk and mortality associated with HIV infection: a national case-control study in Nigeria. [Journal Article]
- CONCLUSIONS: HIV infection was associated with a higher risk of contracting and dying from mpox. Children are also at high risk of death. STIs in mpox cases may be suggestive of high-risk sexual behaviours among these individuals.
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