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2,207 results
  • Bdellovibrio and Like Organisms in Lake Geneva: An Unseen Elephant in the Room? [Journal Article]
    Front Microbiol. 2020; 11:98.Ezzedine JA, Jacas L, … Jacquet S
  • When considering microbial biotic interactions, viruses as well as eukaryotic grazers are known to be important components of aquatic microbial food webs. It might be the same for bacterivorous bacteria but these groups have been comparatively less studied. This is typically the case of the Bdellovibrio and like organisms (BALOs), which are obligate bacterial predators of other bacteria. Recently…
  • Revealing the Variation and Stability of Bacterial Communities in Tomato Rhizosphere Microbiota. [Journal Article]
    Microorganisms. 2020 Jan 25; 8(2)Cheng Z, Lei S, … Tian B
  • Microorganisms that colonize the plant rhizosphere can contribute to plant health, growth and productivity. Although the importance of the rhizosphere microbiome is known, we know little about the underlying mechanisms that drive microbiome assembly and composition. In this study, the variation, assembly and composition of rhizobacterial communities in 11 tomato cultivars, combined with one culti…
  • Assessing passive rehabilitation for carbon gains in rain-filled agricultural wetlands. [Journal Article]
    J Environ Manage. 2020 Feb 15; 256:109971.Treby S, Carnell PE, … Macreadie PI
  • Wetland ecosystems have a disproportionally large influence on the global carbon cycle. They can act as carbon sinks or sources depending upon their location, type, and condition. Rehabilitation of wetlands is gaining popularity as a nature-based approach to helping mitigate climate change; however, few studies have empirically tested the carbon benefits of wetland restoration, especially in fres…
  • MYXO-CTERM sorting tag directs proteins to the cell surface via the type II secretion system. [Journal Article]
    Mol Microbiol. 2020 May; 113(5):1038-1051.Sah GP, Cao P, Wall D
  • Cells interact with their surrounding environment through surface proteins. However, knowledge gaps remain in understanding how these important types of proteins are transported and anchored on the cell surface. In the Gram-negative social bacterium, Myxococcus xanthus, a putative C-terminal sorting tag (MYXO-CTERM) is predicted to help direct 34 different proteins onto the cell surface. Here we …
  • A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays. [Journal Article]
    PLoS Genet. 2019 12; 15(12):e1008533.Guiseppi A, Vicente JJ, … Mauriello EMF
  • Chemosensory systems are highly organized signaling pathways that allow bacteria to adapt to environmental changes. The Frz chemosensory system from M. xanthus possesses two CheW-like proteins, FrzA (the core CheW) and FrzB. We found that FrzB does not interact with FrzE (the cognate CheA) as it lacks the amino acid region responsible for this interaction. FrzB, instead, acts upstream of FrzCD in…
  • Enhypyrazinones A and B, Pyrazinone Natural Products from a Marine-Derived Myxobacterium Enhygromyxa sp. [Journal Article]
    Mar Drugs. 2019 Dec 12; 17(12)Zhang F, Braun DR, … Bugni TS
  • To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wide array of biological activities. Marine-derived myxobacteria are especially at…
  • ParB-type DNA Segregation Proteins Are CTP-Dependent Molecular Switches. [Journal Article]
    Cell. 2019 12 12; 179(7):1512-1524.e15.Osorio-Valeriano M, Altegoer F, … Thanbichler M
  • During cell division, newly replicated DNA is actively segregated to the daughter cells. In most bacteria, this process involves the DNA-binding protein ParB, which condenses the centromeric regions of sister DNA molecules into kinetochore-like structures that recruit the DNA partition ATPase ParA and the prokaroytic SMC/condensin complex. Here, we report the crystal structure of a ParB-like prot…
  • Automated identification of Myxobacterial genera using Convolutional Neural Network. [Journal Article]
    Sci Rep. 2019 12 03; 9(1):18238.Sajedi H, Mohammadipanah F, Pashaei A
  • The Myxococcales order consist of eleven families comprising30 genera, and are featured by the formation of the highest level of differential structure aggregations called fruiting bodies. These multicellular structures are essential for their resistance in ecosystems and is used in the primitive identification of these bacteria while their accurate taxonomic position is confirmed by the nucleoti…
  • Mechanisms for bacterial gliding motility on soft substrates. [Journal Article]
    Proc Natl Acad Sci U S A. 2019 12 10; 116(50):25087-25096.Tchoufag J, Ghosh P, … Mandadapu KK
  • The motility mechanism of certain prokaryotes has long been a mystery, since their motion, known as gliding, involves no external appendages. The physical principles behind gliding still remain poorly understood. Using myxobacteria as an example of such organisms, we identify here the physical principles behind gliding motility and develop a theoretical model that predicts a 2-regime behavior of …
  • MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus. [Journal Article]
    Nat Commun. 2019 11 22; 10(1):5300.Galicia C, Lhospice S, … Cherfils J
  • In Myxococcus xanthus, directed movement is controlled by pole-to-pole oscillations of the small GTPase MglA and its GAP MglB. Direction reversals require that MglA is inactivated by MglB, yet paradoxically MglA and MglB are located at opposite poles at reversal initiation. Here we report the complete MglA/MglB structural cycle combined to GAP kinetics and in vivo motility assays, which uncovers …
  • Self-identity barcodes encoded by six expansive polymorphic toxin families discriminate kin in myxobacteria. [Journal Article]
    Proc Natl Acad Sci U S A. 2019 12 03; 116(49):24808-24818.Vassallo CN, Wall D
  • Myxobacteria are an example of how single-cell individuals can transition into multicellular life by an aggregation strategy. For these and all organisms that consist of social groups of cells, discrimination against, and exclusion of, nonself is critical. In myxobacteria, TraA is a polymorphic cell surface receptor that identifies kin by homotypic binding, and in so doing exchanges outer membran…
  • In depth natural product discovery - Myxobacterial strains that provided multiple secondary metabolites. [Review]
    Biotechnol Adv. 2020 Mar - Apr; 39:107480.Bader CD, Panter F, Müller R
  • In recognition of many microorganisms ability to produce a variety of secondary metabolites in parallel, Zeeck and coworkers introduced the term "OSMAC" (one strain many compounds) around the turn of the century. Since then, additional efforts focused on the systematic characterization of a single bacterial species ability to form multiple secondary metabolite scaffolds. With the beginning of the…
  • Transcriptome dynamics of the Myxococcus xanthus multicellular developmental program. [Journal Article]
    Elife. 2019 10 14; 8Muñoz-Dorado J, Moraleda-Muñoz A, … Pérez J
  • The bacterium Myxococcus xanthus exhibits a complex multicellular life cycle. In the presence of nutrients, cells prey cooperatively. Upon starvation, they enter a developmental cycle wherein cells aggregate to produce macroscopic fruiting bodies filled with resistant myxospores. We used RNA-Seq technology to examine the transcriptome of the 96 hr developmental program. These data revealed that 1…
  • A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis. [Journal Article]
    Science. 2019 10 04; 366(6461):128-132.Gallego-García A, Monera-Girona AJ, … Elías-Arnanz M
  • Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond. These lipids are found in animals and some bacteria and have proposed membrane organization, signaling, and antioxidant roles. We discovered the plasmanylethanolamine desaturase activity that is essential for vinyl ether bond formation in a bacterial enzyme, CarF, which is a homolog of the human enzyme TMEM189. CarF medi…
  • The structure of bactofilin filaments reveals their mode of membrane binding and lack of polarity. [Journal Article]
    Nat Microbiol. 2019 12; 4(12):2357-2368.Deng X, Gonzalez Llamazares A, … Löwe J
  • Bactofilins are small β-helical proteins that form cytoskeletal filaments in a range of bacteria. Bactofilins have diverse functions, from cell stalk formation in Caulobacter crescentus to chromosome segregation and motility in Myxococcus xanthus. However, the precise molecular architecture of bactofilin filaments has remained unclear. Here, sequence analysis and electron microscopy results revea…
  • Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases. [Journal Article]
    Nat Commun. 2019 09 06; 10(1):4055.Gemperlein K, Dietrich D, … Müller R
  • Long-chain polyunsaturated fatty acids (LC-PUFAs), particularly the omega-3 LC-PUFAs eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), have been associated with beneficial health effects. Consequently, sustainable sources have to be developed to meet the increasing demand for these PUFAs. Here, we demonstrate the design and construction of artificial PUFA b…
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