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(N Engl J Med [JO] AND ("Novel Coronavirus" OR COVID-19 OR SARS-CoV-2 OR 2019-nCoV))
190 results
  • A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19. [Journal Article]
    N Engl J Med. 2020 Jun 03 [Online ahead of print]Boulware DR, Pullen MF, … Hullsiek KH
  • CONCLUSIONS: After high-risk or moderate-risk exposure to Covid-19, hydroxychloroquine did not prevent illness compatible with Covid-19 or confirmed infection when used as postexposure prophylaxis within 4 days after exposure. (Funded by David Baszucki and Jan Ellison Baszucki and others; number, NCT04308668.).
  • Remdesivir for 5 or 10 Days in Patients with Severe Covid-19. [Journal Article]
    N Engl J Med. 2020 May 27 [Online ahead of print]Goldman JD, Lye DCB, … GS-US-540-5773 Investigators
  • CONCLUSIONS: In patients with severe Covid-19 not requiring mechanical ventilation, our trial did not show a significant difference between a 5-day course and a 10-day course of remdesivir. With no placebo control, however, the magnitude of benefit cannot be determined. (Funded by Gilead Sciences; GS-US-540-5773 number, NCT04292899.).
  • Hospitalization and Mortality among Black Patients and White Patients with Covid-19. [Journal Article]
    N Engl J Med. 2020 May 27 [Online ahead of print]Price-Haywood EG, Burton J, … Seoane L
  • CONCLUSIONS: In a large cohort in Louisiana, 76.9% of the patients who were hospitalized with Covid-19 and 70.6% of those who died were black, whereas blacks comprise only 31% of the Ochsner Health population. Black race was not associated with higher in-hospital mortality than white race, after adjustment for differences in sociodemographic and clinical characteristics on admission.
  • Remdesivir for the Treatment of Covid-19 - Preliminary Report. [Journal Article]
    N Engl J Med. 2020 May 22 [Online ahead of print]Beigel JH, Tomashek KM, … ACTT-1 Study Group Members
  • CONCLUSIONS: Remdesivir was superior to placebo in shortening the time to recovery in adults hospitalized with Covid-19 and evidence of lower respiratory tract infection. (Funded by the National Institute of Allergy and Infectious Diseases and others; ACCT-1 number, NCT04280705.).
  • Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. [Journal Article]
    N Engl J Med. 2020 May 21 [Online ahead of print]Ackermann M, Verleden SE, … Jonigk D
  • CONCLUSIONS: In our small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection. The universality and clinical implications of our observations require further research to define. (Funded by the National Institutes of Health and others.).
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