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77,102 results
  • PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. [Journal Article]
    Nat Commun 2019; 10(1):3790Fons NR, Sundaram RK, … Bindra RS
  • Pediatric high-grade gliomas are among the deadliest of childhood cancers due to limited knowledge of early driving events in their gliomagenesis and the lack of effective therapies available. In this study, we investigate the oncogenic role of PPM1D, a protein phosphatase often found truncated in pediatric gliomas such as DIPG, and uncover a synthetic lethal interaction between PPM1D mutations a…
  • TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death. [Journal Article]
    Science 2019; 365(6455):799-803Wan L, Essuman K, … Nishimura MT
  • Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors activate cell death and confer disease resistance by unknown mechanisms. We demonstrate that plant Toll/interleukin-1 receptor (TIR) domains of NLRs are enzymes capable of degrading nicotinamide adenine dinucleotide in its oxidized form (NAD+). Both cell death induction and NAD+ cleavage activity of plant TIR domains require know…
  • NAD+ cleavage activity by animal and plant TIR domains in cell death pathways. [Journal Article]
    Science 2019; 365(6455):793-799Horsefield S, Burdett H, … Kobe B
  • SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD+) during Wallerian degeneration associated with neuropathies. Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors recognize pathogen effector proteins and trigger localized cell death to restrict pathogen infection. Both processes depend on c…
  • Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice. [Journal Article]
    Diabetes 2019Cheng Y, Liu J, … Zhai Q
  • Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and type 2 diabetes, but any treatment towards the development of DPN is yet not available. Axon degeneration is an early feature of many peripheral neuropathies, including DPN. Delay of axon degeneration has beneficial effects on various neurodegenerative diseases, but its effect on DPN is yet to be elucidated. D…
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