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23,411 results
  • Berberine Mediated Positive Inotropic Effects on Rat Hearts via a Ca2+-Dependent Mechanism. [Journal Article]
    Front Pharmacol. 2020; 11:821.Zhao J, Wang Y, … Xin W
  • Previous studies showed that berberine, an alkaloid from Coptis Chinensis Franch, might exert a positive inotropic effect on the heart. However, the underlying mechanisms were unclear. Here, we reported that berberine at 10-20 µM increased the left ventricular (LV) developed pressure and the maximal rate of the pressure rising, and it increased the maximal rate of the pressure descending at 20 µM…
  • Mechanism of manganese dysregulation of dopamine neuronal activity. [Journal Article]
    J Neurosci. 2020 Jun 23 [Online ahead of print]Lin M, Colon-Perez LM, … Khoshbouei H
  • Manganese exposure produces Parkinson's-like neurological symptoms, suggesting a selective dysregulation of dopamine transmission. It is unknown, however, how manganese accumulates in dopaminergic brain regions or how it regulates the activity of dopamine neurons. Our in vivo studies in male C57BLJ mice suggest manganese accumulates in dopamine neurons of the ventral tegmental area and substantia…
  • New Phenotypic Cytotoxicity Assay for ROS-inducing Compounds using Rat Renal Epithelial Cells. [Journal Article]
    Toxicol Lett. 2020 Jun 06 [Online ahead of print]Uchiyama N, Yukawa T, … Naven RT
  • An important mechanism of chemical toxicity is the induction of oxidative stress through the production of excess reactive oxygen species (ROS). In this study, we show that the level of drug-induced ROS production between NRK52E and HepG2 cells is significantly different for several marketed drugs and a number of Takeda's internal proprietary compounds. Nifedipine, a calcium channel blocker and t…
  • Case report of a familial triple: a syndrome and review of the literature. [Case Reports]
    Medicine (Baltimore). 2020 May 29; 99(22):e20474.Gaiani F, Gismondi P, … Manfredi M
  • CONCLUSIONS: AS is a rare multisystemic disorder. The longer diagnosis is delayed, the greater extent to which this syndrome may be life-threatening, mainly because of hypoglycemia due to adrenal insufficiency. In AS, the red-flag symptom of alacrimia should instigate investigation for achalasia, Addison disease, and achalasia, addisonianism, alacrimia syndrome gene mutation.
  • Diagnosis and treatment of a diaphragmatic pheochromocytoma: A case report. [Case Reports]
    Int J Surg Case Rep. 2020 May 07; 71:78-81.Wu X, Jin B, … Sang X
  • CONCLUSIONS: Diaphragmatic pheochromocytoma is a rare kind of ectopic pheochromocytomas, which can also affect the patient's quality of life. Combination of qualitative and positioning tests can assist in diagnosis of ectopic pheochromocytoma. Surgical resection is an effective treatment method.
  • Folium Sennae and emodin reverse airway smooth muscle contraction. [Journal Article]
    Cell Biol Int. 2020 May 21 [Online ahead of print]Qiu JY, Ma LQ, … Liu QH
  • The objective of this project was to find a bronchodilatory compound from herbs and clarify the mechanism. We found that the ethanol extract of Folium Sennae (EEFS) can relax airway smooth muscle (ASM). EEFS inhibited ASM contraction, induced by acetylcholine, in mouse tracheal rings and lung slices. High-performance liquid chromatography assay showed that EEFS contained emodin. Emodin had a simi…
  • The Effects of Different Calcium Channel Blockers on Aldosterone-Producing Adenoma Cells. [Journal Article]
    Front Endocrinol (Lausanne). 2020; 11:260.Wang F, Ma X, … Li Y
  • Purpose: The aim of this study is to examine the effects of different kinds of calcium channel blockers (CCBs) on primary aldosterone-producing adenoma (APA) mainly with KCNJ5 mutations. Primary cultured APA cells were treated with different calcium channel blockers (L/T type CCB benidipine, T-type CCB mibefradil and L-type CCB nifedipine), and aldosterone secretagogues with or without nifedipin…
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