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Unbound Medicine.
(NREM)
3,928 results
  • Deep learning enables sleep staging from photoplethysmogram for patients with suspected sleep apnea. [Journal Article]
    Sleep. 2020 May 21 [Online ahead of print]Korkalainen H, Aakko J, … Leppänen T
  • CONCLUSIONS: The PPG-based deep learning model enabled accurate estimation of sleep time and differentiation between sleep stages with a moderate agreement to manual EEG-based scoring. As PPG is already included in ambulatory polygraphic recordings, applying the PPG-based sleep staging could improve their diagnostic value by enabling simple, low-cost, and reliable monitoring of sleep and help assess otherwise overlooked conditions such as REM-related OSA.
  • Melatonin Therapy Improves Cardiac Autonomic Modulation in Pinealectomized Patients. [Journal Article]
    Front Endocrinol (Lausanne). 2020; 11:239.Campos LA, Bueno C, … Cipolla-Neto J
  • The purpose of this investigational study was to assess the effects of melatonin replacement therapy on cardiac autonomic modulation in pinealectomized patients. This was an open-label, single-arm, single-center, proof-of-concept study consisting of a screening period, a 3-month treatment period with melatonin (3 mg/day), and a 6-month washout period. The cardiac autonomic function was determined…
  • Genetic/idiopathic generalized epilepsies: Not so good as that! [Review]
    Rev Neurol (Paris). 2020 May 15 [Online ahead of print]Nilo A, Gelisse P, Crespel A
  • Genetic or idiopathic generalized epilepsies (IGEs) account for 15-20% of all epilepsies. These syndromes have always been considered as good prognosis forms of epilepsy over time; however, for some patients, there is a need to maintain antiseizure drugs (ASD) for a long-time. Drug resistance is not uncommon (7-15%). Lifestyle remains essential and is an integral part of the treatment. Comorbidit…
  • EEG changes associated with subjective under- and overestimation of sleep duration. [Journal Article]
    Sleep. 2020 May 15 [Online ahead of print]Lecci S, Cataldi J, … Siclari F
  • Feeling awake although sleep recordings indicate clear-cut sleep occurs sometimes in good sleepers and to an extreme degree in patients with so-called paradoxical insomnia. It is unknown what underlies sleep misperception, as standard polysomnographic (PSG) parameters are often normal in these cases. Here we asked whether regional spectral power changes could account for the mismatch between obje…
  • Sleep neurophysiology in childhood onset schizophrenia. [Journal Article]
    J Sleep Res. 2020 Apr 30 [Online ahead of print]Markovic A, Buckley A, … Tarokh L
  • Altered sleep neurophysiology has consistently been reported in adult patients with schizophrenia. Converging evidence suggests that childhood onset schizophrenia (COS), a rare but severe form of schizophrenia, is continuous with adult onset schizophrenia. The aim of the current study was to characterize sleep neurophysiology in COS. An overnight sleep electroencephalogram (EEG) was recorded in 1…
  • The Role of Polysomnography in Identifying Sleep Disorders in Children with Migraine. [Journal Article]
    J Med Life. 2020 Jan-Mar; 13(1):64-67.Nita SA, Teleanu RI, Bajenaru OA
  • Migraine pathophysiology and sleep share common neural pathways, and there are clinical as well as paraclinical observations, which lead to the hypothesis of an association between migraine and sleep disorders. The objective of this study consisted of the evaluation of a possible correlation between migraine and sleep disorders in children, as reflected by sleep architecture and electroencephalog…
  • The Effect of Zolpidem on Memory Consolidation Over a Night of Sleep. [Journal Article]
    Sleep. 2020 Apr 24 [Online ahead of print]Zhang J, Yetton B, … Mednick SC
  • Non-rapid eye movement sleep boosts hippocampus-dependent, long-term memory formation more so than wake. Studies have pointed to several electrophysiological events that likely play a role in this process, including thalamo-cortical sleep spindles (12-15Hz). However, interventional studies that directly probe the causal role of spindles in consolidation are scarce. Previous studies have used zolp…
  • Association of eszopiclone, zaleplon, or zolpidem with complex sleep behaviors resulting in serious injuries, including death. [Journal Article]
    Pharmacoepidemiol Drug Saf. 2020 Apr 22 [Online ahead of print]Harbourt K, Nevo ON, … Croteau D
  • CONCLUSIONS: The FAERS and medical literature cases support the need for increased awareness of the consequences that may occur because of CSBs associated with the use of Z-drugs. Therefore, to protect public health, regulatory actions were taken, including adding a Boxed Warning, a Contraindication in patients who have experienced a prior episode of a CSB with a Z-drug, and updating the existing Warnings and Precautions. An FDA Drug Safety Communication was also disseminated to alert healthcare professionals and the public of this potential risk.
  • Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy. [Journal Article]
    Elife. 2020 Apr 21; 9Hung CJ, Ono D, … Yamanaka A
  • Orexin/hypocretin-producing and melanin-concentrating hormone-producing (MCH) neurons are co-extensive in the hypothalamus and project throughout the brain to regulate sleep/wakefulness. Ablation of orexin neurons decreases wakefulness and results in a narcolepsy-like phenotype, whereas ablation of MCH neurons increases wakefulness. Since it is unclear how orexin and MCH neurons interact to regul…
  • Phase-based coordination of hippocampal and neocortical oscillations during human sleep. [Journal Article]
    Commun Biol. 2020 Apr 20; 3(1):176.Cox R, Rüber T, … Fell J
  • During sleep, new memories undergo a gradual transfer from hippocampal (HPC) to neocortical (NC) sites. Precisely timed neural oscillations are thought to mediate this sleep-dependent memory consolidation, but exactly how sleep oscillations instantiate the HPC-NC dialog remains elusive. Employing overnight invasive electroencephalography in ten neurosurgical patients, we identified three broad cl…
  • Hypothalamic MCH Neuron Activity Dynamics during Cataplexy of Narcolepsy. [Journal Article]
    eNeuro. 2020 Mar/Apr; 7(2)Sun Y, Liu M
  • Hypothalamic orexin (hypocretin, HCRT) deficiency causes sleep disorder narcolepsy with cataplexy in humans and murine. As another integral group of sleep/wake-regulating neurons in the same brain area, the melanin-concentrating hormone (MCH) neurons' involvement in cataplexy remains ambiguous. Here we used the live animal deep-brain calcium (Ca2+) imaging tool to record MCH neuron dynamics durin…
  • Hippocampal Interictal Spikes during Sleep Impact Long-Term Memory Consolidation. [Journal Article]
    Ann Neurol. 2020 Jun; 87(6):976-987.Lambert I, Tramoni-Negre E, … Bartolomei F
  • CONCLUSIONS: Our results show that activation of interictal spikes in the hippocampus during sleep and seizures specifically impair long-term memory consolidation. We hypothesize that hippocampal interictal spikes during sleep interrupt hippocampal-neocortical transfer of information. ANN NEUROL 2020;87:976-987.
  • Episodic memory consolidation during sleep in healthy aging. [Review]
    Sleep Med Rev. 2020 Mar 16; 52:101304.Muehlroth BE, Rasch B, Werkle-Bergner M
  • Sleep benefits the stabilization of newly acquired information - a process known as memory consolidation. Age-related alterations in sleep physiology may affect memory consolidation and account for reduced episodic memory performance in healthy older individuals. The striking parallelism of age-related changes in sleep and episodic memory has provoked a considerable increment in empirical studies…
  • Effectiveness of pediatric drug-induced sleep endoscopy for REM-predominant obstructive sleep apnea. [Journal Article]
    Sleep Breath. 2020 Apr 10 [Online ahead of print]Smith DF, He S, … Ishman SL
  • CONCLUSIONS: For children with OSA without tonsillar hypertrophy, DISE using DEX/ketamine was useful to predict at least one site of obstruction, even for those with REM-predominant OSA. DISE-directed outcomes resulted in significant improvements in mean oAHI, total sleep time, sleep efficiency, saturation nadir, and the proportion with oAHI < 5, after surgery for some children with REM-predominant disease.
  • EEG microstates are correlated with brain functional networks during slow-wave sleep. [Journal Article]
    Neuroimage. 2020 Apr 07; 215:116786.Xu J, Pan Y, … Gao JH
  • Electroencephalography (EEG) microstates have been extensively studied in wakefulness and have been described as the "atoms of thought". Previous studies of EEG have found four microstates, i.e., microstates A, B, C and D, that are consistent among participants across the lifespan during the resting state. Studies using simultaneous EEG and functional magnetic resonance imaging (fMRI) have provid…
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