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43,627 results
  • From Textile Coloring to Light-emitting Electrochemical Devices: Upcycling of the Isoviolanthrone Vat Dye. [Journal Article]
    Chem Asian J. 2023 Feb 08 [Online ahead of print]Ghanem T, Leong KK, … Cabanetos C
  • Produced at ton scale, vat dyes are major environmental pollutants generated by the textile industry. However, they represent ideal and accessible candidates for chemical upcycling since they are usually composed of large π-conjugated scaffolds. Based on the valorization of "old" products, waste or even contaminant into high-added value goods, this concept can be easily transposed to the laborato…
  • Nanonized carbamazepine for nose-to-brain delivery: pharmaceutical formulation development. [Journal Article]
    Pharm Dev Technol. 2023 Feb 07 [Online ahead of print]Bonaccorso A, Gigliobianco MR, … Musumeci T
  • Epilepsy is one of the most common neurological disorders in the world. The therapeutic treatment is challenging since conventional drugs have limited efficacy and several side effects that impair patient management. Efforts are being made to find innovative strategies to control epileptic seizures. Intranasal administration provides a convenient route to deliver drug to the brain. Carbamazepine …
  • Man vs Microbes - The Race of the Century. [Journal Article]
    J Med Microbiol. 2023 Jan; 72(1)Anderson E, Nair B, … Kumar G
  • The complexity of the antimicrobial resistance (AMR) crisis and its global impact on healthcare invokes an urgent need to understand the underlying forces and to conceive and implement innovative solutions. Beyond focusing on a traditional pathogen-centric approach to antibiotic discovery yielding diminishing returns, future therapeutic interventions can expand to focus more comprehensively on ho…
  • Surface engineering of colloidal nanoparticles. [Review]
    Mater Horiz. 2023 Feb 07 [Online ahead of print]Jing X, Zhang Y, … Zheng J
  • Synthesis of engineered colloidal nanoparticles (NPs) with delicate surface characteristics leads to well-defined physicochemical properties and contributes to multifunctional applications. Surface engineering of colloidal NPs can improve their stability in diverse solvents by inhibiting the interparticle attractive forces, thus providing a prerequisite for further particle manipulation, fabricat…
  • Bioactive multi-protein adsorption enables targeted mast cell nanotherapy. [Preprint]
    Res Sq. 2023 Jan 26Du F, Rische C, … Scott E
  • Proteins readily and often irreversibly adsorb to nanomaterial surfaces, resulting in denaturation and loss of bioactivity1,2. Controlling this process to preserve protein structure and function has remained an elusive goal that would enhance the fabrication and biocompatibility of protein-based bioactive nanomaterials3-7. Here, we demonstrate that poly(propylene sulfone) (PPSU)8 nanoparticles su…
  • Ultra-small polydopamine nanomedicine-enabled antioxidation against senescence. [Journal Article]
    Mater Today Bio. 2023 Apr; 19:100544.Han J, Wang J, … Zhao RC
  • Senescence is a cellular response characterized by cells irreversibly stopping dividing and entering a state of permanent growth arrest. One of the underlying pathophysiological causes of senescence is the oxidative stress-induced damage, indicating that eliminating the reactive oxygen and nitrogen species (RONS) may be beneficial to prevent and/or alleviate senescence. Herein, we developed ultra…
  • Boosting Checkpoint Immunotherapy with Biomaterials. [Review]
    ACS Nano. 2023 Feb 06 [Online ahead of print]Liu L, Pan Y, … Rao L
  • The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the rapid advances in nanotechnology and materials science, various types of biomaterials have been developed to maximize therapeutic efficacy while minimizing side effects by increasing tumor antigenicity, reversing immuno…
  • Insight on nano drug delivery systems with targeted therapy in treatment of oral cancer. [Review]
    Nanomedicine. 2023 Feb 04 [Online ahead of print]Vyas K, Rathod M, Patel MM
  • Oral cancer is a type of cancer that develops in the mouth and is one of the deadliest malignancies in the world. Currently surgical, radiation therapy, and chemotherapy are most common treatments. Better treatment and early detection strategies are required. Chemotherapeutic drugs fail frequently due to toxicity and poor tumor targeting. There are high chances of failure of chemotherapeutic drug…
  • Caco-2 cell-derived biomimetic electrochemical biosensor for cholera toxin detection. [Journal Article]
    Biosens Bioelectron. 2023 Jan 28; 226:115105.Kim Y, Lee D, … Yoon DS
  • Cholera is a highly contagious and lethal waterborne disease induced by an infection with Vibrio cholerae (V. cholerae) secreting cholera toxin (CTx). Cholera toxin subunit B (CTxB) from the CTx specifically binds with monosialo-tetra-hexosyl-ganglioside (GM1) found on the exterior cell membrane of an enterocyte. Bioinspired by the pathological process of CTx, we developed an electrochemical bios…
  • DNA Nano Trihedron Exhibits an Inhibitory Effect on Breast Cancer Cells. [Journal Article]
    ACS Omega. 2023 Jan 31; 8(4):4385-4390.Wang Y, Chen S, … Liu Y
  • As a new type of nanomaterial, DNA nanomaterials show great potential in biomedical applications because of their high precision, high controllability, and high biocompatibility among other characteristics. Therapeutic drugs based on DNA nanomaterials have been shown to have beneficial therapeutic effects on a variety of diseases. The application of DNA nanomedicines in the treatment of diseases …
  • Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform. [Review]
    Int J Nanomedicine. 2023; 18:509-525.Choi A, Javius-Jones K, … Park H
  • Nanoparticle-based drug delivery systems have been designed to treat various diseases. However, many problems remain, such as inadequate tumor targeting and poor therapeutic outcomes. To overcome these obstacles, cell-based drug delivery systems have been developed. Candidates for cell-mediated drug delivery include blood cells, immune cells, and stem cells with innate tumor tropism and low immun…
  • Nanomedicine-based multimodal therapies: Recent progress and perspectives in colon cancer. [Review]
    World J Gastroenterol. 2023 Jan 28; 29(4):670-681.He YC, Hao ZN, … Gao DW
  • Colon cancer has attracted much attention due to its annually increasing incidence. Conventional chemotherapeutic drugs are unsatisfactory in clinical application because of their lack of targeting and severe toxic side effects. In the past decade, nanomedicines with multimodal therapeutic strategies have shown potential for colon cancer because of their enhanced permeability and retention, high …
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