- From Textile Coloring to Light-emitting Electrochemical Devices: Upcycling of the Isoviolanthrone Vat Dye. [Journal Article]Chem Asian J. 2023 Feb 08 [Online ahead of print]CA
- Produced at ton scale, vat dyes are major environmental pollutants generated by the textile industry. However, they represent ideal and accessible candidates for chemical upcycling since they are usually composed of large π-conjugated scaffolds. Based on the valorization of "old" products, waste or even contaminant into high-added value goods, this concept can be easily transposed to the laborato…
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- Clot-Targeted Antithrombotic Liposomal Nanomedicine Containing High Content of H2O2-Activatable Hybrid Prodrugs. [Journal Article]ACS Appl Mater Interfaces. 2023 Feb 07 [Online ahead of print]AA
- Liposomes have been extensively explored as drug carriers, but their clinical translation has been hampered by their low drug-loading content and premature leakage of drug payloads. It was reasoned that vesicle-forming prodrugs could be incorporated into the lipid bilayer at a high molar fraction and therefore serve as a therapeutic agent as well as a structural component in liposomal nanomedicin…
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- Mucoadhesive Dendrons Conjugated to Mesoporous Silica Nanoparticles as a Drug Delivery Approach for Orally Administered Biopharmaceuticals. [Journal Article]ACS Appl Mater Interfaces. 2023 Feb 07 [Online ahead of print]AA
- Biological drugs are increasingly important for patients and industry due to their application in the treatment of common and potentially life-threatening diseases such as diabetes, cancer, and obesity. While most marketed biopharmaceuticals today are injectables, the potential of mucoadhesive delivery systems based on dendron-coated mesoporous silica nanoparticles for oral delivery of biological…
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- Impact of Formulation design and Lyophilization on the Physicochemical Characteristics of Finasteride Nanosystems. [Journal Article]J Microencapsul. 2023 Feb 07 [Online ahead of print]JM
- CONCLUSIONS: The lyophilized FNS-NS was stable for 90 days at proper storage conditions. The FNS-NS with 15% trehalose had appropriate physicochemical attributes that could be a promising carrier for topical delivery to treat androgenic alopecia.
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- Effective treatment of retinal neovascular leakage with fusogenic porous silicon nanoparticles delivering VEGF-siRNA. [Journal Article]Nanomedicine (Lond). 2023 Feb 07 [Online ahead of print]N
- Aim: To evaluate an intravitreally injected nanoparticle platform designed to deliver VEGF-A siRNA to inhibit retinal neovascular leakage as a new treatment for proliferative diabetic retinopathy and diabetic macular edema. Materials & methods: Fusogenic lipid-coated porous silicon nanoparticles loaded with VEGF-A siRNA, and pendant neovascular integrin-homing iRGD, were evaluated for efficacy by…
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- Nanomedicines Reprogram Synovial Macrophages by Scavenging Nitric Oxide and Silencing CA9 in Progressive Osteoarthritis. [Journal Article]Adv Sci (Weinh). 2023 Feb 07 [Online ahead of print]AS
- Osteoarthritis (OA) is a progressive joint disease characterized by inflammation and cartilage destruction, and its progression is closely related to imbalances in the M1/M2 synovial macrophages. A two-pronged strategy for the regulation of intracellular/extracellular nitric oxide (NO) and hydrogen protons for reprogramming M1/M2 synovial macrophages is proposed. The combination of carbonic anhyd…
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- Nanonized carbamazepine for nose-to-brain delivery: pharmaceutical formulation development. [Journal Article]Pharm Dev Technol. 2023 Feb 07 [Online ahead of print]PD
- Epilepsy is one of the most common neurological disorders in the world. The therapeutic treatment is challenging since conventional drugs have limited efficacy and several side effects that impair patient management. Efforts are being made to find innovative strategies to control epileptic seizures. Intranasal administration provides a convenient route to deliver drug to the brain. Carbamazepine …
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- Man vs Microbes - The Race of the Century. [Journal Article]J Med Microbiol. 2023 Jan; 72(1)JM
- The complexity of the antimicrobial resistance (AMR) crisis and its global impact on healthcare invokes an urgent need to understand the underlying forces and to conceive and implement innovative solutions. Beyond focusing on a traditional pathogen-centric approach to antibiotic discovery yielding diminishing returns, future therapeutic interventions can expand to focus more comprehensively on ho…
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- Surface engineering of colloidal nanoparticles. [Review]Mater Horiz. 2023 Feb 07 [Online ahead of print]MH
- Synthesis of engineered colloidal nanoparticles (NPs) with delicate surface characteristics leads to well-defined physicochemical properties and contributes to multifunctional applications. Surface engineering of colloidal NPs can improve their stability in diverse solvents by inhibiting the interparticle attractive forces, thus providing a prerequisite for further particle manipulation, fabricat…
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- Bioactive multi-protein adsorption enables targeted mast cell nanotherapy. [Preprint]Res Sq. 2023 Jan 26RS
- Proteins readily and often irreversibly adsorb to nanomaterial surfaces, resulting in denaturation and loss of bioactivity1,2. Controlling this process to preserve protein structure and function has remained an elusive goal that would enhance the fabrication and biocompatibility of protein-based bioactive nanomaterials3-7. Here, we demonstrate that poly(propylene sulfone) (PPSU)8 nanoparticles su…
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- Ultra-small polydopamine nanomedicine-enabled antioxidation against senescence. [Journal Article]Mater Today Bio. 2023 Apr; 19:100544.MT
- Senescence is a cellular response characterized by cells irreversibly stopping dividing and entering a state of permanent growth arrest. One of the underlying pathophysiological causes of senescence is the oxidative stress-induced damage, indicating that eliminating the reactive oxygen and nitrogen species (RONS) may be beneficial to prevent and/or alleviate senescence. Herein, we developed ultra…
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- Role of vanadium ions substitution on spinel MnCo2O4 towards enhanced electrocatalytic activity for hydrogen generation. [Journal Article]Sci Rep. 2023 Feb 06; 13(1):2120.SR
- Improving efficient electrocatalysts (ECs) for hydrogen generation through water splitting is of significant interest in tackling the upcoming energy crisis. Sustainable hydrogen generation is the primary prerequisite to realizing the future hydrogen economy. This work examines the electrocatalytic activity of hydrothermally prepared vanadium doped MnCo spinel oxide microspheres (MC), MnVxCo2-xO4…
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- Boosting Checkpoint Immunotherapy with Biomaterials. [Review]ACS Nano. 2023 Feb 06 [Online ahead of print]AN
- The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the rapid advances in nanotechnology and materials science, various types of biomaterials have been developed to maximize therapeutic efficacy while minimizing side effects by increasing tumor antigenicity, reversing immuno…
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- Understanding mucus modulation behavior of chitosan oligomers and dextran sulfate combining light scattering and calorimetric observations. [Journal Article]Carbohydr Polym. 2023 Apr 15; 306:120613.CP
- This study reports the fundamental understanding of mucus-modulatory strategies combining charged biopolymers with distinct molecular weights and surface charges. Here, key biophysical evidence supports that low-molecular-weight (Mw) polycation chitosan oligosaccharides (COSs) and high-Mw polyanion dextran sulfate (DS) exhibit distinct thermodynamic signatures upon interaction with mucin (MUC), t…
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- A dandelion-like nanomedicine via hierarchical self-assembly for synergistic chemotherapy and photo-dynamic cancer therapy. [Journal Article]Nanomedicine. 2023 Feb 04 [Online ahead of print]N
- The synergistic effect of chemotherapy and photo-dynamic therapy (PDT) is an effective way to improve the efficiency of tumor treatment. However, most synergistic therapeutic drugs have poor water solubility and stability, so it is difficult to achieve high therapeutic effects while avoiding the severe side effects. Herein, a unique dandelion-like nanomedicine (named as cRGDfk-CCPT-mCe6) was succ…
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- Insight on nano drug delivery systems with targeted therapy in treatment of oral cancer. [Review]Nanomedicine. 2023 Feb 04 [Online ahead of print]N
- Oral cancer is a type of cancer that develops in the mouth and is one of the deadliest malignancies in the world. Currently surgical, radiation therapy, and chemotherapy are most common treatments. Better treatment and early detection strategies are required. Chemotherapeutic drugs fail frequently due to toxicity and poor tumor targeting. There are high chances of failure of chemotherapeutic drug…
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- Blocking Spatiotemporal Crosstalk between Subcellular Organelles for Enhancing Anticancer Therapy with Nanointercepter. [Journal Article]Adv Mater. 2023 Feb 06 [Online ahead of print]AM
- The spatiotemporal characterization of signaling crosstalk between subcellular organelles is crucial for the therapeutic effect of malignant tumors. Blocking interactive crosstalk in this fashion is significant but challenging. Herein, we report a communication interception strategy, which blocks spatiotemporal crosstalk between subcellular organelles for cancer therapy with underlying molecular …
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- Comparative study of the efficiency of silicon carbide, boron nitride and carbon nanotube to deliver cancerous drug, azacitidine: A DFT study. [Journal Article]Comput Biol Med. 2023 Jan 30; 154:106593.CB
- Herein we have made a comparative study of the efficiency of three different nanotubes viz. Carbon nanotube (CNT), boron nitride nanotube (BNNT) and silicon carbide nanotube (SiCNT) to deliver the cancerous drug, Azacitidine (AZD). The atomistic description of the encapsulation process of AZD in these nanotubes has been analyzed by evaluating parameters like adsorption energy, electrostatic poten…
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- Nano-hydroxyapatite radiolabeled with radium dichloride [223Ra] RaCl2 for bone cancer targeted alpha therapy: In vitro assay and radiation effect on the nanostructure. [Journal Article]Colloids Surf B Biointerfaces. 2023 Jan 26; 223:113174.CS
- The use of targeted alpha therapy (TAT) for bone cancer is increasing each year. Among the alpha radionuclides, radium [223Ra]Ra+2 is the first one approved for bone cancer metastasis therapy. The development of novel radiopharmaceutical based on [223Ra]Ra+2 is essential to continuously increase the arsenal of new TAT drugs. In this study we have developed, characterized, and in vitro evaluated […
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- Development of KLA-RGD integrated lipopeptide with the effect of penetrating membrane which target the αvβ3 receptor and the application of combined antitumor. [Journal Article]Colloids Surf B Biointerfaces. 2023 Feb 02; 223:113186.CS
- Herein, an amphiphilic cationic anticancer lipopeptide P17 with α-helical structure was synthesized based on the integration of KLA and RGD peptide which could bind with the receptor of integrin αvβ3. P17 could self assemble into stable spherical aggregates in aqueous solution, and which could encapsulate the anticancer drugs (Such as Dox) to form P17 @ Anticancer drug nanomedicine (P17 @ Dox nan…
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- Caco-2 cell-derived biomimetic electrochemical biosensor for cholera toxin detection. [Journal Article]Biosens Bioelectron. 2023 Jan 28; 226:115105.BB
- Cholera is a highly contagious and lethal waterborne disease induced by an infection with Vibrio cholerae (V. cholerae) secreting cholera toxin (CTx). Cholera toxin subunit B (CTxB) from the CTx specifically binds with monosialo-tetra-hexosyl-ganglioside (GM1) found on the exterior cell membrane of an enterocyte. Bioinspired by the pathological process of CTx, we developed an electrochemical bios…
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- The outcome of boosting mitochondrial activity in alcoholic liver disease (ALD) is organ-dependent. [Journal Article]Hepatology. 2023 Feb 07 [Online ahead of print]Hep
- CONCLUSIONS: Improving mitochondrial respiration by liver-specific Mcj silencing might become a novel therapeutic approach for treating ALD.
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- Hydrothermally Derived Green Carbon Dots from Broccoli Water Extracts: Decreased Toxicity, Enhanced Free-Radical Scavenging, and Anti-Inflammatory Performance. [Journal Article]ACS Biomater Sci Eng. 2023 Feb 06 [Online ahead of print]AB
- Biomass carbon dots (CDs) derived from natural plants possess the advantages of low cost, photostability, and excellent biocompatibility, with potential applications in chemical sensing, bioimaging, and nanomedicine. However, the development of biomass CDs with excellent antioxidant activity and good biocompatibility is still a challenge. Herein, we propose a hypothesis for enhancing the antioxid…
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- Biogenic Nanoparticles: Synthesis, characterization, and Biological potential of Gold Nanoparticles synthesized using Lasiosiphon Eriocephalus Decne Plant Extract. [Journal Article]Pharm Nanotechnol. 2023 Feb 06 [Online ahead of print]PN
- CONCLUSIONS: Findings from this study revealed that gold nanoparticles synthesized using L. eriocephalus, it showed remarkable antioxidant, antimicrobial, and extensive cytotoxicity and genotoxicity activities.
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- Novel Pt(IV) prodrug self-assembled nanoparticles with enhanced blood circulation stability and improved antitumor capacity of oxaliplatin for cancer therapy. [Journal Article]Drug Deliv. 2023 Dec; 30(1):2171158.DD
- Pt(IV) compounds are regarded as prodrugs of active Pt(II) drugs (i.e. cisplatin, carboplatin, and oxaliplatin) and burgeoned as the most ideal candidates to substitute Pt(II) anticancer drugs with severe side effects. Nanoparticle drug delivery systems have been widely introduced to deliver Pt(IV) prodrugs more effectively and safely to tumors, but clinical outcomes were unpredictable owing to l…
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- Biomarkers: Promising and valuable tools towards diagnosis, prognosis and treatment of Covid-19 and other diseases. [Review]
- The use of biomarkers as early warning systems in the evaluation of disease risk has increased markedly in the last decade. Biomarkers are indicators of typical biological processes, pathogenic processes, or pharmacological reactions to therapy. The application and identification of biomarkers in the medical and clinical fields have an enormous impact on society. In this review, we discuss the hi…
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- DNA Nano Trihedron Exhibits an Inhibitory Effect on Breast Cancer Cells. [Journal Article]
- As a new type of nanomaterial, DNA nanomaterials show great potential in biomedical applications because of their high precision, high controllability, and high biocompatibility among other characteristics. Therapeutic drugs based on DNA nanomaterials have been shown to have beneficial therapeutic effects on a variety of diseases. The application of DNA nanomedicines in the treatment of diseases …
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- Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform. [Review]
- Nanoparticle-based drug delivery systems have been designed to treat various diseases. However, many problems remain, such as inadequate tumor targeting and poor therapeutic outcomes. To overcome these obstacles, cell-based drug delivery systems have been developed. Candidates for cell-mediated drug delivery include blood cells, immune cells, and stem cells with innate tumor tropism and low immun…
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- Flexible Hollow Human Serum Albumin-Catalase Nanocapsules with High Accumulation and Uptake Ability for Enhanced Photodynamic Therapy. [Journal Article]
- Photodynamic therapy (PDT) has attracted increasing attention for tumor treatment because of its minimal invasiveness and specific spatiotemporal selectivity. However, insufficient tumor accumulation and low cellular uptake of photosensitizers limit its therapeutic efficacy.
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- Nanomedicine-based multimodal therapies: Recent progress and perspectives in colon cancer. [Review]
- Colon cancer has attracted much attention due to its annually increasing incidence. Conventional chemotherapeutic drugs are unsatisfactory in clinical application because of their lack of targeting and severe toxic side effects. In the past decade, nanomedicines with multimodal therapeutic strategies have shown potential for colon cancer because of their enhanced permeability and retention, high …
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